Melatonin inhibits oxytocin and vasopressin release from the neurointermediate lobe of the hamster pituitary

Juszczak, Marlena; Debéljuk, Luciano; Bartke, Andrzej; Stempniak, B

doi:10.1097/00001756-199512150-00004

Cited by 15 publications

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“…1A) and OT ( Fig. 2A) release from the H-NH system, which accords with previous results obtained when rat hypothalamus [11] or hamster neurointermediate lobe [13] were incubated in vitro. Melatonin, at a concentration of 10 -11 M, remained inactive in influencing the AVP and OT output from isolated rat H-NH complex (Fig.…”

Section: Discussionsupporting

confidence: 92%

“…Melatonin, at a concentration of 10 -11 M, remained inactive in influencing the AVP and OT output from isolated rat H-NH complex (Fig. 1A and 2A) or rat hypothalamus [11], but when hamster neurointermediate lobe was incubated in vitro, the three concentrations of melatonin (10 -11 , 10 -9 and 10 -7 M) induced inhibitory effects of similar magnitude on OT and AVP release [13]. What is more, the highest concentration of melatonin used in our present experiments, i.e.…”

Section: Discussionmentioning

confidence: 88%

“…The observed discrepancies may result from the fact that for the present in vitro experiments we used the explants which contained intact neuronal projections from the hypothalamic SON and PVN nuclei to the neurohypophysis, i.e. intact axons of the oxytocinergic and vasopressinergic neurones, while in the other studies only isolated hypothalamus [11] or neurohypophysis [9,13] were incubated in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…When Syrian hamsters were used as donors of the tissue, the inhibitory effect of melatonin on AVP and OT secretion from the neurointermediate lobe was also noted [13]. Since melatonin has been shown to have either a stimulatory or an inhibitory influence, or to be without effect on AVP or OT secretion from isolated hypothalamus or neurointermediate lobe, the primary purpose of the present study was, therefore, to investigate whether melatonin affects the in vitro release of AVP and OT from isolated rat hypothalamo-neurohypophysial system in a dose-dependent manner.…”

Section: Streszczeniementioning

confidence: 99%

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Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

Roszczyk¹,

Juszczak²

2014

Endokrynologia Polska

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Introduction: Previous in vivo and in vitro studies have shown that melatonin changes vasopressin (AVP) and oxytocin (OT) secretion from the rat neurohypophysis. Additionally, melatonin is known to inhibit the forskolin-induced (forskolin is a strong adenylyl cyclase -AC activator) increase in cAMP accumulation in the rat pituitary. To determine whether the possible response of vasopressinergic and/or oxytocinergic neurones to melatonin could be mediated through a cAMP-dependent mechanism, the effect of different concentrations of melatonin (i.e. 10

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Streszczeniementioning

confidence: 99%

See 2 more Smart Citations

Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

Roszczyk¹,

Juszczak²

2014

Endokrynologia Polska

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“…Several factors, which play a role as neuromediators and/or neuromodulators in the central nervous system, were found to influence this hormone secretion [1][2][3][4]. One of these factors is melatonin, which is able to modify OT secretion under different physiological and pathological conditions both in vivo [5][6] and in vitro [7][8][9][10][11]. The results, however, have shown that melatonin has either a stimulatory or an inhibitory effect, or is without influence on OT secretion, according to its concentration, the time of the day, animal species, and tissue sample (hypothalamus or neurohypophysis, or hypothalamo-neurohypophysial system) incubated in vitro.…”

Section: Introductionmentioning

confidence: 99%

Rola błonowych receptorów melatoniny w zależnym od melatoniny uwalnianiu oksytocyny z układu podwzgórze-część nerwowa przysadki szczura — badania in vitro oraz in vivo

Juszczak

Wolak

Bojanowska

et al. 2016

Endokrynologia Polska

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The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system -an in vitro and in vivo approach Rola błonowych receptorów melatoniny w zależnym od melatoniny uwalnianiu oksytocyny z układu podwzgórze-część nerwowa przysadki szczura -badania in vitro oraz in vivo AbstractIntroduction: Melatonin exerts its biological role acting mainly via G protein-coupled membrane MT 1 and MT 2 receptors. To determine whether a response of oxytocinergic neurons to different concentrations of melatonin is mediated through membrane MT 1 and/or MT 2 receptors, the effect of melatonin receptors antagonists, i.e. luzindole (a non-selective antagonist of both MT 1 and MT 2 receptors) and 4-phenyl-2-propionamidotetralin (4-P-PDOT -a selective antagonist of MT 2 receptor), on melatonin-dependent oxytocin (OT) secretion from the rat hypothalamo-neurohypophysial (H-N) system, has been studied both in vitro and in vivo. Materials and methods: For in vitro experiment, male rats served as donors of the H-N explants, which were placed in 1 ml of normal Krebs-Ringer fluid (nKRF) heated to 37

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The effects of short photoperiod, pinealectomy, and melatonin treatment on oxytocin synthesis and release in the male syrian hamster

Juszczak

Steger

Debéljuk

et al. 1996

Endocr

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The pineal gland has been shown to affect plasma oxytocin (OT) levels, but the mechanism of this action is not apparent. In the present study, the ability of the photoperiod to affect plasma OT levels, neurointermediate lobe (NIL) OT content, and hypothalamic OT mRNA levels was studied in male Syrian hamsters. In addition, the ability of pinealectomy to prevent and melatonin (MEL) to mimic the short photoperiod-induced changes were also determined. Exposure to short days (SD) led to the expected decrease in testes weight and plasma PRL levels, but plasma OT levels were unchanged. However, NIL OT content was increased in the SD-exposed animals. Hypothalamic OT mRNA levels were not significantly altered by SD exposure. Pinealectomy blocked the effects of SD on testes weight, whereas afternoon MEL injections mimicked the effects of SD. In long day (LD)-exposed hamsters, pinealectomy induced a decrease in NIL OT content without altering hypothalamic OT mRNA levels. In SD-exposed animals, NIL OT content was not affected by pinealectomy. Melatonin injections had no significant effect on NIL OT content or hypothalamic OT mRNA levels. The data from the present study suggest that exposure of male Syrian hamsters to short photoperiods influences some aspects of OT synthesis and/or transport to produce its increased accumulation in the NIL, but does not affect OT release. These changes are apparently not the result of SD-induced changes in MEL secretion, but conceivably could be related to the previously documented effects of SD on hypothalamic catecholamine turnover.

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Melatonin inhibits oxytocin and vasopressin release from the neurointermediate lobe of the hamster pituitary

Cited by 15 publications

References 0 publications

Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

Rola błonowych receptorów melatoniny w zależnym od melatoniny uwalnianiu oksytocyny z układu podwzgórze-część nerwowa przysadki szczura — badania in vitro oraz in vivo

The effects of short photoperiod, pinealectomy, and melatonin treatment on oxytocin synthesis and release in the male syrian hamster

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