Melatonin-loaded chitosan/Pluronic® F127 microspheres as in situ forming hydrogel: An innovative antimicrobial wound dressing

Romić, Marieta Duvnjak; Klarić, Maja Šegvić; Lovrić, Jasmina; Pepić, Ivan; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena; Hafner, Anita

doi:10.1016/j.ejpb.2016.06.013

Cited by 79 publications

(47 citation statements)

References 61 publications

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“…that the hydrogels made of chitosan, poly(ethylene glycol) and polyvinylpyrrolidone could work as antimicrobial and scar preventive dressings. Moreover, chitosan‐based hydrogels are regarded as carriers to deliver the therapeutic drugs topically, such as vancomycin, peptide Ser‐Ile‐Lys‐Val‐Ala‐Val, melatonin, tigecycline, bFGF, and honey bee . These drugs have at least one of following functions: (1) antibacterial; (2) anti‐inflammatory; (3) angiogenesis; and (4) the promotion of fibroblast proliferation, thus, facilitating to skin repair.…”

Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…As melatonin and Pluronic F127 demonstrated no antimicrobial and antibiofilm activity individually, it was thought that they potentiate the antimicrobial activity of chitosan. The potentiating effect observed here was attributed to the inclusion of Pluronic F127 into the microsphere matrix, promoting the amorphization of melatonin, which exhibited a potentiating effect on chitosan …”

Section: Surfactant Interaction With Antimicrobialsmentioning

confidence: 71%

“…Pluronic F127 (Poloxamer 407) is a non‐ionic surfactant that has been shown to enhance the rate of the wound healing process. In a study evaluating the antimicrobial properties of a wound dressing containing melatonin‐loaded chitosan/Pluronic F127 microspheres, enhanced antimicrobial and antibiofilm activity was found against S. aureus in comparison to chitosan, melatonin, and Pluronic F127 only . As melatonin and Pluronic F127 demonstrated no antimicrobial and antibiofilm activity individually, it was thought that they potentiate the antimicrobial activity of chitosan.…”

Section: Surfactant Interaction With Antimicrobialsmentioning

confidence: 99%

Mode of action of poloxamer‐based surfactants in wound care and efficacy on biofilms

Percival¹,

Chen²,

Mayer

et al. 2018

International Wound Journal

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Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or chronic wounds show clinical signs of delayed healing, persistent inflammation, and the production of non-viable tissue. These types of wounds also present challenges such as infection and potentially house antimicrobial-tolerant biofilms. The use of wound cleansers to aid cleaning and debridement of the wound is essential. A large proportion of skin and wound cleansers contain surfactants but there is only a small amount of data that shows the effectiveness of them in the enhancement of wound closure. This review paper aims to explore the available literature surrounding the use and mode of action of surfactants in wound healing, in particular Poloxamer 188 (Pluronic F-68) and Poloxamer 407 (Pluronic F-127), and also uncover the potential mechanisms behind the enhancement of wound healing and comparison to other surfactants used in wound care. Furthermore, the presence of a microbial biofilm in the wound is a significant factor in delayed wound healing. Therefore, the effect of clinically used surfactants on biofilms will be discussed, with emphasis on poloxamer-based surfactants.

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“…Similarly, in periodontal diseases, melatonin has been shown to reduce the biofilm formation of P. gingivalis at 200 μg mL −1 (Zhou et al ., ). In wound infection, melatonin reduced the biofilm formation of Staphylococcus aureus ATCC 29213 at 670 μg mL −1 (Romic et al ., ). The length of RS105 flagella under melatonin treatment was shorter than that in control group.…”

Section: Discussionmentioning

confidence: 97%

Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv. oryzicola

et al. 2018

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Rice bacterial leaf streak (BLS), caused by Xanthomonas oryzae pv. oryzicola (Xoc), is a prevalent disease worldwide. Melatonin, an indoleamine with the chemical name N‐acetyl‐5‐methoxytryptamine, is known to inhibit the growth of human pathogenic bacteria. However, the impact of melatonin on agricultural pathogenic bacteria remains poorly understood. In this study, the effect of melatonin on Xoc was investigated. Exogenous melatonin (200 μg mL−1) significantly inhibited the growth of Xoc and reduced the mRNA expression level of seven cell division‐related genes. Melatonin reduced the pathogenicity of Xoc towards the susceptible rice IR24. The lesion length in IR24 infected by Xoc pretreated with melatonin (200 μg mL−1) was more than 23% smaller than the lesion length of the control group. Similarly, infection of IR24 leaves by Xoc pretreated with melatonin (200 μg mL−1) reduced the bacterial population by 45%. The biofilm formation, swimming motility and extracellular protease activities of Xoc also decreased under melatonin treatment. Melatonin only slightly changed the morphology of Xoc but significantly reduced the mRNA expression of toxin genes. Furthermore, treating leaves with exogenous melatonin reduced the incidence of BLS by 17%. It is reported for the first time that melatonin reduces pathogenicity and may serve as a bactericide for controlling BLS disease.

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Melatonin-loaded chitosan/Pluronic® F127 microspheres as in situ forming hydrogel: An innovative antimicrobial wound dressing

Cited by 79 publications

References 61 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Mode of action of poloxamer‐based surfactants in wound care and efficacy on biofilms

Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv. oryzicola

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