2014
DOI: 10.1016/j.exger.2014.10.014
|View full text |Cite
|
Sign up to set email alerts
|

Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
12
0

Year Published

2015
2015
2022
2022

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 13 publications
(13 citation statements)
references
References 77 publications
(117 reference statements)
1
12
0
Order By: Relevance
“…The therapy persisted either of daily intraperitoneal melatonin injections (8 mg/kg)—dissolved in 0.9% saline—(JL‐Mel) or of environmental enrichment as a lifestyle approach (JL‐ENR). We considered 8 mg/kg as appropriate as several studies reported that this melatonin dose has beneficial effects on adult hippocampal neurogenesis . Environmental enrichment consisted of an enlarged cage (0.74 m×0.3 m×0.74 m) containing a rearrangeable set of plastic tubes, colourful cartons, cardboard tubes, grids, varying shelters, and alternating food and drinking spots .…”
Section: Methodsmentioning
confidence: 99%
“…The therapy persisted either of daily intraperitoneal melatonin injections (8 mg/kg)—dissolved in 0.9% saline—(JL‐Mel) or of environmental enrichment as a lifestyle approach (JL‐ENR). We considered 8 mg/kg as appropriate as several studies reported that this melatonin dose has beneficial effects on adult hippocampal neurogenesis . Environmental enrichment consisted of an enlarged cage (0.74 m×0.3 m×0.74 m) containing a rearrangeable set of plastic tubes, colourful cartons, cardboard tubes, grids, varying shelters, and alternating food and drinking spots .…”
Section: Methodsmentioning
confidence: 99%
“…Golgi-Cox impregnation was revealed with 18.7% ammonia solution and fixed in Kodak rapid fix (Kodak, Rochester, NY, USA). Brain slices were dehydrated and clarified in Neoclear before they were coverslipped with Neomount medium (Merck, Whitehouse Station, NJ, USA) [ 35 , 36 ]. Twenty Golgi-stained neurons in the granule cell layer (GCL) of the dentate gyrus were analyzed to determine dendritic spine density in every 10 μm of secondary dendrites of rodents exposed to either control- or RVTL (40 mg/kg).…”
Section: Methodsmentioning
confidence: 99%
“…Hippocampi from control- or RVTL-treated mice were dissected and lysed as reported previously [ 35 , 36 ]. Control- and RVTL-treated mice were housed under normal conditions in groups of 4–5 animals.…”
Section: Methodsmentioning
confidence: 99%
“…The beneficial effects of melatonin on SGZ precursors may rely on its capacity to increase the levels of phospho-c-Raf and phosphoextracellular signal-regulated kinase 1/2 (ERK1/2) through melatonin receptor [77]. Other studies have reported neuroprotective effect of melatonin in different animal models, including irradiation, aging, spinal cord injury, ischemia, hypoxia, and pinealectomy [3437, 54, 7780]. …”
Section: Discussionmentioning
confidence: 99%
“…This hormone mediates its effects through the cell membrane receptors MT1 and MT2 [23, 24] and regulates antioxidant enzymes [25, 26] by switching on/off intracellular signaling cascades [27, 28], as well as by scavenging oxygen free radical [2933]. In addition, melatonin promotes neurogenesis under diverse conditions, such as ovariectomy, pinealectomy, aging, or circadian disruption [17, 3440]. In this study, we used a prophylactic administration of melatonin for 14 days (before and during 96 hours of REMSD) to determine if melatonin exerted a protective effect in neural precursor cells.…”
Section: Introductionmentioning
confidence: 99%