Melatonin mediates seasonal adjustments in immune function

Therapeutic benefit of melatonin in refractory central serous chorioretinopathy

“…In fact, it was shown that the inhibitory effect on glucocorticoid actions is involved in melatonin modulation of the immune system. 7 Although the molecular mechanisms regarding the antagonism between melatonin and glucocorticoids are still unclear, it was shown that melatonin inhibits glucocorticoid receptor mRNA expression 50 and modulates glucocorticoids receptor ligand interaction. 51 Furthermore, we have demonstrated that melatonin inhibits apoptosis of rat thymocytes induced by glucocorticoid.…”

“…6,7 Besides the pineal gland, melatonin is also biosynthesized in the retina, where it behaves as an endogenous neuromodulator. 8 Although it has been shown that melatonin may provide neuroprotection in different systems, 9 the full range of actions of melatonin is still not completely known.…”

Effect constant and natural illumination on physiological state in rats

“…Уровень мелатонина положительно коррелирует как с гуморальным (Akbulut et al, 2001), так и с клеточным иммунитетом (Brennan et al, 2002;Champney et al, 1997). Введение экзогенного мелатонина в периоды, когда наблюдается снижение активности пинеальной железы (Nelson, Drazen, 1999;Haldar et al, 2001), приводит к усилению отдельных показателей иммунитета. Лимфоциты способны синтезировать мелатонин, что является дополнительным свидетельством участия мелатонина в регуляции иммунной системы (Carrillo-Vico et al, 2004).…”

Effect of seasonal variation on the clinical course of chronic hepatitis B

“…However, it is now known that a wide variety of extrinsic and intrinsic factors can affect and, in many cases, mediate immune responses. [23][24][25][26][27][28][29][30][31][32] Therefore, there is no doubt that the rhythms or variations of immune function often vary seasonally. [11][12][13][14][15][16] Such seasonality has been found not only in animals 16,19,33,34 but also in normal humans 18,20,35,36 and associated with some diseases.…”