Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats

Xie, Lingling; Chen, Rui; Li, Zhuangzhuang; Li, Shanshan; Fan, Yong-Jian; Qi, Man-Man

doi:10.1016/j.neulet.2022.136754

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…The heme oxygenase-1 (HO-1)/CREB signaling pathway is involved not only in the development of depression-like behaviors that can be developed after an ischemic episode, but also in the transformation of astrocytes into a neurotoxic and inflammatory type cell. Melatonin interacts with HO-1/CREB, inducing an anti-depression effect [220].…”

Section: Exploring the Neuroprotective Potential Of Melatonin In Stro...mentioning

confidence: 99%

“…Melatonin has been shown to partially reverse TBI-induced anxiety-like behavior in rats and decrease the number of activated astrocytes and neuronal apoptosis in the amygdala induced by TBI [415]. Melatonin also has been demonstrated to decrease the number of A1-type astrocytes in the NAc after TBI and mitigate TBI-induced depression by activating of HO-1/CREB signaling [220]. Similar results have been obtained in the hippocampus, dentate gyrus [300], and cortex [300,416] where melatonin reduces activated astrocytes and cytokine production and promotes cell survival and cognitive function after TBI induction.…”

Section: Melatonin In Astrocyte Activationmentioning

confidence: 99%

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Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Carretero,

Ramos,

Segura-Chama

et al. 2023

Antioxidants

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The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered significant attention in recent years due to its diverse physiological functions and potential therapeutic benefits by reducing oxidative stress, inflammation, and apoptosis. Melatonin has been found to mitigate ischemic brain damage caused by stroke. By scavenging free radicals and reducing oxidative damage, melatonin may help slow down the aging process and protect against age-related cognitive decline. Additionally, non-excitatory amino acids have been shown to possess neuroprotective properties, including antioxidant and anti-inflammatory in stroke and aging-related conditions. They can attenuate oxidative stress, modulate calcium homeostasis, and inhibit apoptosis, thereby safeguarding neurons against damage induced by stroke and aging processes. The intracellular accumulation of certain non-excitatory amino acids could promote harmful effects during hypoxia-ischemia episodes and thus, the blockade of the amino acid transporters involved in the process could be an alternative therapeutic strategy to reduce ischemic damage. On the other hand, the accumulation of free radicals, specifically mitochondrial reactive oxygen and nitrogen species, accelerates cellular senescence and contributes to age-related decline. Recent research suggests a complex interplay between melatonin, free radicals, and non-excitatory amino acids in stroke and aging. The neuroprotective actions of melatonin and non-excitatory amino acids converge on multiple pathways, including the regulation of calcium homeostasis, modulation of apoptosis, and reduction of inflammation. These mechanisms collectively contribute to the preservation of neuronal integrity and functions, making them promising targets for therapeutic interventions in stroke and age-related disorders.

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Section: Exploring the Neuroprotective Potential Of Melatonin In Stro...mentioning

confidence: 99%

Section: Melatonin In Astrocyte Activationmentioning

confidence: 99%

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Carretero,

Ramos,

Segura-Chama

et al. 2023

Antioxidants

View full text Add to dashboard Cite

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“…In addition, in ammation and trauma were on the rise (Weina et al, 2018). In ammation caused by pro-in ammatory cytokines such as interleukin 1α (IL-1α), interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) is strongly associated with depression (Feng et al, 2022;Xie et al, 2022).Severe depression, elevated serum or plasma levels of IL-6 and C-reactive protein (CRP) were frequently observed by investigators in their studies. Therefore, anti-cytokine therapy was a potential therapy for PSD (Kappelmann et Furthermore, the researchers found that 5-HT, NE and DA neurons were directly or indirectly connected in the CNS.…”

Section: Group 1: Study Of Risk Factors For Depression After Strokementioning

confidence: 99%

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Yang

et al. 2023

Preprint

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Background Post-stroke depression(PSD) is one of the most common complications of stroke which affects recovery and quality of patients’ life adversely. PSD also is a significant source of burden for caregivers. Recently, the number of publications on PSD has been an increasing worldwide that means PSD has attracted more and more attention. Therefore, a more comprehensive understanding of the publications on PSD is now required. The purpose of this paper is to analyze the research status, discover the hotspots and frontiers about PSD. Methods The publications’ raw data was retrieved from the Web of Science Core Collection on September 19, 2022. Impact Factor (IF) and Journal Citation Reports (JCR) segments of the publications were obtained from the Web of Science website. Visualization analysis was performed on CiteSpace and VOSviewer. Results From 2012 to 2022, the number of citations and publications about PSD increased exponentially year by year. Finally, a total of 3268 publications related to PSD were identified. China (867) and the US (738) had the most publications; Capital Med Univ and Univ Melbourne were the most prolific institutions. Ungvari GS and Hackett ML were the most active authors and the most prolific and co-cited, respectively. Journal of stroke cerebrovascular diseases (131 articles) was the highest output. Among the 3268 publications, International journal of stroke had the most citations (43.9 times), Stroke has the most citations (2,990) and the highest H-index value. The citation burst for 8 co-cited references lasts until 2022. Finally, this paper divided the hot spots into four categories: cluster 1 (study on risk factors of PSD), cluster 2 (clinically relevant research on PSD), cluster 3 (mechanisms of PSD), and cluster 4 (the Treatment Study for PSD). Conclusion PSD research is one research main area worldwide. This work demonstrated the knowledge structure and the evolution of the PSD research field and predictdresearches trends through visual analysis. The study of clinical treatment and prevention of PSD will instead of the study of the mechanism in the future. This study provides reference for future research of PSD.

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“…Furthermore, studies using animal model to investigate Alzheimer’s disease (AD), which is a progressive irreversible neurodegenerative disorder, have shown that melatonin has also neuroprotective properties in AD, demonstrated in vivo and in vivo in preclinical studies [ 50 ], leading to the reduction of the AD progression in the patient condition.…”

Section: In Vivo Animal Model For the Study Of Pineal Glandmentioning

confidence: 99%

Pineal Gland from the Cell Culture to Animal Models: A Review

Peruri

Morgan

D’Souza

et al. 2022

Life

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This review demonstrates current literature on pineal gland physiology, pathology, and animal model experiments to concisely explore future needs in research development with respect to pineal gland function and neuro-regenerative properties. The pineal gland plays an integral role in sleep and recovery by promoting physiologic circadian rhythms via production and release of melatonin. Yet, the current literature shows that the pineal gland has neuroprotective effects that modulate both peripheral and central nerve injuries through several direct and indirect mechanisms, such as angiogenesis and induction of growth factors and anti-inflammatory mediators. Animal models have also shown correlations between pineal gland function and metabolic homeostasis. Studies have shown that a functional pineal gland is essential in preventing and slowing the progression of certain diseases such as diabetes, osteoporosis, vertebral osteoarthritis, and neurodegenerative processes. Lastly, the array of cell culturing methods and animal models that can be used to further develop the study of pineal gland function and nervous system injury were reviewed.

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Melatonin mitigates traumatic brain injury-induced depression-like behaviors through HO-1/CREB signal in rats

Cited by 6 publications

References 37 publications

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Pineal Gland from the Cell Culture to Animal Models: A Review

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