Melatonin modulates 900 MHz microwave-induced lipid peroxidation changes in rat brain

Abstract

Microwaves (MW) from cellular phones may affect biological systems by increasing free radicals, which may enhance lipid peroxidation levels of the brain, thus leading to oxidative damage. Melatonin is synthesized in and secreted by the pineal gland at night and exhibits anti-oxidant properties. Several studies suggest that supplementation with anti-oxidant can influence MW-induced brain damage. The present study was designed to determine the effects of MW on the brain lipid peroxidation system, and the possible protective effects of melatonin on brain degeneration induced by MW. Twenty-eight Sprague-Dawley male rats were randomly divided into three groups as follows: (1) sham-operated control group (N = 8); (2) study 900-MHz MW-exposed group (N = 8); and (3) 900-MHz MW-exposed+melatonin (100 microg/kg sc before daily MW exposure treated group) (N = 10). Cortex brain and hippocampus tissues were removed to study the levels of lipid peroxidation as malonyl dialdehyde. The levels of lipid peroxidation in the brain cortex and hippocampus increased in the MW group compared with the control group, although the levels in the hippocampus were decreased by MW+melatonin administration. The brain cortex lipid peroxidation levels were unaffected by melatonin treatment. We conclude that melatonin may prevent MW-induced oxidative changes in the hippocampus by strengthening the anti-oxidant defense system, by reducing oxidative stress products.

Effects of exposure to a mobile phone on sexual behavior in adult male rabbit: an observational study

“…However, with EMW exposure and the suggested occurrence of oxidative stress, the efficiency of these antioxidant mechanisms will be lost. This will result in an increase in reactive oxygen species production, 30,31 which may lead to cellular damage. 32 A limitation of this study is that we did not determine the level of oxidative stress in the brains of our animals.…”

The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation

“…3). Ozguner et al [28,29] also reported reduced catalase activity caused by exposure to 900 MHz microwaves in the retina and kidney. However, Kesari and Behari [11] recently reported increased catalase activity in testicular tissue after 35 days of exposure to MWs.…”

Impact of L-Carnitine and Selenium Treatment on Testicular Apoptosis in Rats Exposed to 2.45 GHz Microwave Energy

“…On day 28, rats were anaesthetised with a cocktail of ketamine hydrochloride (HCI) [90 mg/kg] and xylazyne HCI (10 mg/kg) which were administered intraperitoneally before being sacrificed as described before (24). Then the testes were removed and put into 10% formaldehyde solution (25).…”