Melatonin prevents overproduction of reactive oxygen species and vascular dysfunction induced by cyclophosphamide

Pimenta, Gustavo F.; Awata, Wanessa M.C.; Orlandin, Gabrielly G.; Silva-Neto, Julio A.; Assis, Victor O.; da Costa, Rafael M.; Bruder-Nascimento, Thiago; Tostes, Rita C.; Tirapelli, Carlos R.

doi:10.1016/j.lfs.2023.122361

Cited by 6 publications

(1 citation statement)

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“…Pimenta and co-workers conducted experiments to evaluate the effect of melatonin on the production of ROS and vascular dysfunction induced by cyclophosphamide and reported that melatonin demonstrated vasoprotective effects. It inhibits NADPH oxidase activity, enhances SOD activity, and elevates reduced glutathione (GSH) levels, while also reducing the production of pro-inflammatory cytokines [ 61 ]. Ren et al reported that melatonin had a protective effect against the harmful effects of oxidative stress in the diabetic aorta, obtained using an STZ-induced diabetic animal model and vascular smooth muscle cells (VSMCs).…”

Section: Antioxidant Properties Of Melatoninmentioning

confidence: 99%

Melatonin and Vascular Function

Mendes,

Queiroz,

Sena

2024

Antioxidants

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The indolamine hormone melatonin, also known as N-acetyl-5-methoxytrypamine, is frequently associated with circadian rhythm regulation. Light can suppress melatonin secretion, and photoperiod regulates melatonin levels by promoting its production and secretion at night in response to darkness. This hormone is becoming more and more understood for its functions as an immune-modulatory, anti-inflammatory, and antioxidant hormone. Melatonin may have a major effect on several diabetes-related disturbances, such as hormonal imbalances, oxidative stress, sleep disturbances, and mood disorders, according to recent research. This has raised interest in investigating the possible therapeutic advantages of melatonin in the treatment of diabetic complications. In addition, several studies have described that melatonin has been linked to the development of diabetes, cancer, Alzheimer’s disease, immune system disorders, and heart diseases. In this review, we will highlight some of the functions of melatonin regarding vascular biology.

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Section: Antioxidant Properties Of Melatoninmentioning

confidence: 99%