Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

Dezfouli, Mitra Ansari; Zahmatkesh, Maryam; Farahmandfar, Maryam; Khodagholi, Fariba

doi:10.1016/j.physbeh.2019.02.016

Cited by 40 publications

(16 citation statements)

References 74 publications

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“…Also, it has been established that melatonin decreases the progression of senescence and may delay neurodegenerative progression [220]. Melatonin was found to prevent striatal degeneration and improve motor function in a rat model of PD as well as reduce the Aβ-induced neurotoxicity in rats (Table 1) [72,73]. Canakinumab is a human anti-monoclonal antibody which has been shown promising in treating RA in clinical trials [99].…”

Section: Potential Treatment For Inflammaging-related Diseasesmentioning

confidence: 99%

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo

Stetskiv

et al. 2019

IJMS

362

201

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It has been proposed that a chronic state of inflammation correlated with aging known as inflammaging, is implicated in multiple disease states commonly observed in the elderly population. Inflammaging is associated with over-abundance of reactive oxygen species in the cell, which can lead to oxidation and damage of cellular components, increased inflammation, and activation of cell death pathways. This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis. Recently published mechanistic details of the roles of reactive oxygen species in inflammaging and various diseases will also be discussed. Advancements in potential treatments to ameliorate inflammaging, oxidative stress, and consequently, reduce the morbidity of multiple disease states will be explored.

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Section: Potential Treatment For Inflammaging-related Diseasesmentioning

confidence: 99%

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo

Stetskiv

et al. 2019

IJMS

362

201

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“…Melatonin is a pleiotropic hormone secreted primarily from the pineal gland at night . As well as playing an important role in circadian biology, melatonin has an emerging role in neuroprotection . Because patients with neurodegenerative diseases such as Alzheimer's and Parkinson's disease show disturbed circadian rest‐activity rhythms, melatonin has been considered as a potential treatment in both diseases .…”

Section: Introductionmentioning

confidence: 99%

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

Morton

Middleton

Rudiger

et al. 2019

Journal of Pineal Research

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Melatonin is a pleiotrophic hormone, synthesised primarily by the pineal gland under the control of the suprachiasmatic nuclei (SCN). It not only provides a hormonal signal of darkness but also has neuroprotective properties. Huntington's disease (HD) is a progressive neurodegenerative disorder characterised by abnormal motor, cognitive and psychiatric symptoms. There is growing evidence, particularly from animal models, that circadian rhythms may also be disturbed in HD. We measured two circadian-regulated hormones, melatonin and cortisol, in plasma samples collected around-the-clock from normal and presymptomatic transgenic HD sheep (Ovis aries) at 5 and 7 years of age, to assess SCN-driven rhythms and the effect of genotype, sex and age. Melatonin-related precursors and metabolites (tryptophan, serotonin, kynurenine) were also measured by liquid chromatography (LC)-mass spectrometry (MS). At 5 years of age in both rams and ewes, plasma melatonin levels were significantly elevated in HD sheep. In ewes measured 2 years later, there was still a significant elevation of nocturnal melatonin. Furthermore, the daytime baseline levels of melatonin were significantly higher in HD sheep. Since increased melatonin could have global beneficial effects on brain function, we suggest that the increased melatonin measured in presymptomatic HD sheep is part of an autoprotective response to mutant huntingtin toxicity that may account, at least in part, for the late onset of disease that characterises HD.

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“…Recent work proposes that mitochondrial sirtuins and the melatonergic pathway have been intimate partners over the course of evolution [64], suggesting that mitochondrial sirtuins and melatonin are closely coordinated in the regulation of mitochondrial function. Melatonin also increases SIRT1 in many cell types, with the protective effects of melatonin against Aβ42 requiring the induction of SIRT1 [65].…”

Section: Gut Sirtuins and Alzheimer's Diseasementioning

confidence: 99%

“…It is also of note that 14-3-3 suppression sensitizing cells to ceramide's apoptotic effects [100]. Ceramide's suppression of the mitochondrial melatonergic pathway will decreases melatonin's induction of, and interaction with, sirtuin-3 [64], thereby contributing to classical AD pathophysiological changes, including tau-associated tangles [98] and Aβ-associated plaques [65]. This is given some support by data showing that cerebrospinal fluid level of total tau and brain atrophy correlate with ceramide levels in AD patients [101].…”

Section: Gut Permeabilitymentioning

confidence: 99%

Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s Disease<strong> </strong>

Anderson¹,

Maes²

2020

Preprint

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Alzheimer's disease (AD) has been the subject of extensive investigation as to its biological underpinnings. However, this has produced little of therapeutic benefit or indeed provided any accepted biomarkers that could tailor treatment. This chapter reviews data on the main pathophysiologic processes that have been widely shown to be altered in AD, including circadian dysregulation, mitochondrial dysfunction, gut dysbiosis, and immune-glia-platelet activation. It is proposed that alterations in the gut microbiome, including gut dysbiosis and increased gut permeability drive changes in mitochondrial function that are intimately associated with significant variations in sirtuin expression. Both mitochondria-located and nucleus/cytoplasm located sirtuins can act on mitochondrial function in different cells and body systems to co-ordinate the ageing-associated changes that underpin AD. The sirtuins are therefore key aspect to a developmental model of AD that is more 'holistic' in perspective, thereby providing a framework for the detection of earlier biomarkers and more successful treatment for the heterogenous nature of AD pathoetiology.

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Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

Cited by 40 publications

References 74 publications

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s Disease<strong> </strong>

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Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

Cited by 40 publications

References 74 publications

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer&rsquo;s Disease<strong> </strong>

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Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s Disease<strong> </strong>