Melatonin protects against lead-induced hepatic and renal toxicity in male rats

El‐Sokkary, Gamal H.; Abdel-Rahman, Gamal H.; Kamel, Esam S.

doi:10.1016/j.tox.2005.05.003

Cited by 104 publications

(86 citation statements)

References 39 publications

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“…It was observed that lead exposure produced pronounced hepatic damage as evident by histological alternations in liver, including focal necrosis with hepatocyte vacuolization and swelling, pyknotic nuclei, as well as dilation of central vein and sinusoids. These findings are in strong support with Sharma et al 26 El-Sokkary et al 27 also showed that liver of lead-treated rats revealed remarkable degenerative alterations. Lead hepatotoxicity led to vacuolization of the cells, polymorphism of the nuclei, and decrease in glycogen content of the hepatocytes.…”

Section: Histological Studiessupporting

confidence: 87%

Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model

Bajpai¹,

Kim²,

Kang³

2017

IJPER

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Background: In recent years, the development of efficient green chemistry approaches for detoxification of heavy metal such as lead (Pb) poisoning has become a major focus of researchers. Objectives: This study was aimed to evaluate the effectiveness of heattreated cucumber juice on the protection of Pb-induced acute liver and kidney damages. Methods: Initially, during detoxification of lead, lead acetate (200 ppm dissolved in distilled water) was given to rats in drinking water for 5 weeks. Cucumber juice was orally administrated following three concentrations (1, 10 and 100 mg/kg) once in a day for 5 weeks. Further, the effect of heat-treated cucumber juice was evaluated on body weight, food intake, lead contents of rat tissues, and histopatholgical analysis of liver and kidney of test animals. Results: As a result, all treatments of cucumber juice exhibited a significantly higher protective effect on body weight, food intake, lead contents of tissues, count of red blood cell (RBC), and reticulocytes, as compared with Pb-control. Moreover, histology, and histomorphometry analysis of treatment tissue samples of liver and kidney also confirmed protecting effect of cucumber juice by showing normal histology and histomorphy when compared with Pb-control. Conclusion: These findings suggested that heat-treated cucumber juice has a significant protective effect on Pbinduced acute liver and kidney damages in experimental rats.

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Section: Histological Studiessupporting

confidence: 87%

Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model

Bajpai¹,

Kim²,

Kang³

2017

IJPER

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“…It has been reported as one of the important mechanism of toxic effect of lead, like other heavy metals (Flora et al 2004b). In the previous studies, heavy metal exposure including lead has been shown increase of ROS production in various experimental animal tissues (El-Sokkary et al 2005;Xia et al 2010). It is known that lead causes biochemical and physiological dysfunctions in humans and laboratory animals (Zhang et al 2010;Kalender et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Malondialdehyde (MDA) is a good marker of membrane lipid peroxidation, resulting from the interaction between ROS and cellular membrane (Durak et al 2010). Lead has been documented to increase the MDA levels in various rat tissues such as liver, brain, kidney and testis (Flora et al 2004a;El-Sokkary et al 2005;Sainath et al 2011). The lipid peroxidation observed as a result of lead administration could be due to the formation of free radicals.…”

Section: Discussionmentioning

confidence: 99%

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Apaydın

Kalender

Baş

et al. 2014

Braz. arch. biol. technol.

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“…It has been found that melatonin has a higher antioxidant efficiency than vitamin E and GSH, which are known as powerful antioxidants [10] . The antioxidant properties of melatonin prevent acute liver injury induced by ischemiareperfusion [23] , irradiation [24] , bile duct ligation [25][26][27] , and toxins [18,28,29] . Several lines of evidence suggest that melatonin plays an important role in regulation of collagen levels and inhibition of collagen accumulation.…”

Section: Discussionmentioning

confidence: 99%

Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats

Ren¹,

Xu²,

Qiao³

2009

WJG

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AIM:To investigate the protective effects of melatonin on carbon tetrachloride (CCl 4 )-induced hepatic fibrosis in experimental rats. METHODS:All rats were randomly divided into normal control group, model control group treated with CCl 4 for 12 wk, CCl 4 + NAC group treated with CCl 4 + NAC (100 mg/kg, i.p.) for 12 wk, CCl 4 + MEL-1 group treated with CCl 4 + melatonin (2.5 mg/kg) for 12 wk, CCl 4 + MEL-2 group treated with CCl 4 + melatonin (5.0 mg/kg) for 12 wk, and CCl 4 + MEL-3 group treated with CCl 4 + melatonin (10 mg/kg). Rats in the treatment groups were injected subcutaneously with sterile CCl 4 (3 mL/kg, body weight) in a ratio of 2:3 with olive oil twice a week. Rats in normal control group received hypodermic injection of olive oil at the same dose and frequency as those in treatment groups. At the end of experiment, rats in each group were anesthetized and sacrificed. Hematoxylin and eosin (HE) staining and Van Gieson staining were used to examine changes in liver pathology. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and protein concentration were measured with routine laboratory methods using an autoanalyzer. Hydroxyproline (HYP) content in liver and malondialdehyde (MDA) and glutathione peroxidase (GPx) levels in liver homogenates were assayed by spectrophotometry. Serum hyaluronic acid (HA), laminin (LN), and procollagen Ⅲ N-terminal peptide (PⅢNP) were determined by radioimmunoassay. RESULTS:Pathologic grading showed that the fibrogenesis was much less severe in CCl 4 + MEL3 group than in model control group (u = 2.172, Moreover, treatment with melatonin (5, 10 mg/kg) significantly reduced the MDA content and increased the GPx activity in liver homogenates compared with model control group (MDA: 7.89 ± 1.49 noml/mg prot vs 6.29 ± 1.42 noml/mg prot and 6.25 ± 2.27 noml/mg prot, respectively, P = 0.015, P = 0.015; GPx: 49.13 ± 8.72 U/mg prot vs 57.38 ± 7.65 U/mg prot and 61.39 ± 13.15 U/mg prot, respectively, P = 0.035, P = 0.003). CONCLUSION:Melatonin can ameliorate CCl 4 -induced hepatic fibrosis in rats. The protective effect of melatonin on hepatic fibrosis may be related to its antioxidant activities.

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Melatonin protects against lead-induced hepatic and renal toxicity in male rats

Cited by 104 publications

References 39 publications

Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model

Protective Effect of Heat-Treated Cucumber (Cucumis sativus L.) Juice Against Lead-Induced Detoxification in Rat Model

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats

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