Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues

Jones, Catherine; Helfer, Gisela; Brandstätter, Roland

doi:10.3109/07420528.2011.642912

Cited by 17 publications

(12 citation statements)

References 42 publications

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“…There are currently three types of melatonin membrane receptors known in birds. These membrane receptors are widely distributed in various tissues and organs, such as the hypothalamus , tectum , eyeball , spleen , bursa of Fabricius , liver and gastrointestinal tract . The three membrane receptors play different roles in different tissues and organs.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of Chicks

Liang

Qin

Liu

et al. 2019

Photochem & Photobiology

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Previous studies have found that melatonin was related to the growth and development in avian. Therefore, the newly hatched broilers were exposed to colors of light to establish a model of pinealectomy and explored the mechanism of pineal melatonin promoting growth hormone (GH) secretion. The results showed that green light (GL) promoted the levels of GH, pituitary‐specific transcription factor‐1 (Pit‐1) genes and proteins in pituitary. Moreover, the mRNA and protein levels of melatonin receptor subtypes Mel1b and Mel1c in the pituitary in GL were higher than other monochromatic light groups. After pinealectomy, the expression of Pit‐1, GH, Mel1b and Mel1c in pituitary decreased. In vitro, exogenous melatonin promoted the level of Pit‐1 mRNA and the secretion of GH in anterior pituitary cells. However, when melatonin was added with exogenous selective Mel1b antagonist (4‐phenyl‐2‐propionamideotetralin) and selective Mel1c antagonist (prazosin), the level of Pit‐1 mRNA and the GH secretion decreased. When selective Mel1b and Mel1c antagonists were added simultaneously, the decrease in Pit‐1 mRNA and GH secretion was more significant. These results indicated that pineal melatonin promotes the expression of Pit‐1 under GL by binding to melatonin receptor subtypes Mel1b and Mel1c in the pituitary, thereby increasing GH secretion and promoting the growth.

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Section: Discussionmentioning

confidence: 99%

Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of Chicks

Liang

Qin

Liu

et al. 2019

Photochem & Photobiology

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“…A phylogenetic tree of melatonin subtype receptor amino acid sequences was previously created [ 71 ], and Figure 4 shows a cladogram by Phylogeny.fr [ 72 , 73 ] of melatonin subtype receptor mRNA sequences from NCBI GenBank ( Table 1 shows the list of NCBI Accession Numbers). Melatonin membrane receptors discussed here include research in mammals, birds, and other non-mammalian vertebrates, specifically elucidating the functional role of melatonin membrane receptor subtypes in the brain and gonads (for studies elucidating melatonin subtype receptors in peripheral tissues in mammals, see [ 44 , 67 , 74 ] and in birds see [ 75 , 76 , 77 , 78 ].…”

Section: Melatonin Bindingmentioning

confidence: 99%

Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen’s Four Questions

viviD

Bentley

2018

Molecules

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One of the many functions of melatonin in vertebrates is seasonal reproductive timing. Longer nights in winter correspond to an extended duration of melatonin secretion. The purpose of this review is to discuss melatonin synthesis, receptor subtypes, and function in the context of seasonality across vertebrates. We conclude with Tinbergen’s Four Questions to create a comparative framework for future melatonin research in the context of seasonal reproduction.

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“…Consequently, melatonin receptor subtypes vary in density and abundance throughout the body. Mel 1A and Mel 1B receptors have been reported in the heart, retina, pineal, liver, and lung of zebra finches [8]. In the shell gland, MEL 1C has been identified as a positional candidate for affecting egg shell thickness [9].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

et al. 2013

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Laying hens often experience unbalanced calcium utilization which can cause deficiencies in bone and egg mineralization. Because melatonin has been shown to affect bone mineralization in other animals, we examined whether treating hens with melatonin would affect eggshell thickness and improve skeletal performance, thereby reducing skeletal and egg shell defects. Birds were given a diet containing either low (30 µg/kg), medium (300 µg/kg), or high (3 mg/kg) concentrations of melatonin, or control feed through approximately one laying cycle. We examined the weight, length, and strength of egg, femur, tibia, and keel. Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls. Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin. Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin. Our data suggest that melatonin may affect the allocation of calcium to bone at the expense of egg shell mineralization.

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Melatonin Receptor Expression in the Zebra Finch Brain and Peripheral Tissues

Abstract: The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress. Melatonin is synthesised and secreted during the night by the pineal gland and released into the circulatory system. It

Cited by 17 publications

References 42 publications

Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of Chicks

Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of Chicks

Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen’s Four Questions

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

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