Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis

Fink, Tobias; Glas, Michael; Wolf, Alexander; Kleber, Astrid; Reus, E.; Wolff, Martin; Kiefer, Daniel; Wolf, Beate; Rensing, Hauke; Volk, Thomas; Mathes, Alexander

doi:10.1097/ccm.0b013e3182a63e2b

Cited by 52 publications

(37 citation statements)

References 39 publications

(58 reference statements)

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“…Similar results were previously reported in the literature using MLT in the treatment of different induced pathological conditions in animal models, such as sepsis [30][31], Alzheimer [32], and liver injury caused by cholangiocarcinoma [33]. Table 2 shows the result for enzyme concentrations associated with liver damage in the 24-hour experiment.…”

Section: Survival Of Animalssupporting

confidence: 84%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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Abstract:Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24-and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

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Section: Survival Of Animalssupporting

confidence: 84%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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show abstract

“…Besides, the antioxidant effects of melatonin also protect the respiratory enzyme complex and mitochondrial deoxyribonucleic acid DNA by ROS. In addition, it has been found in septic rats that the administration of melatonin has been found to increase the levels of different antioxidant compounds, reduce malondialdehyde (MDA) levels as biomarker of lipid peroxidation, improve mitochondrial function, decrease TNF-α and interleukin-6 levels, decrease nitric oxide, reduce biochemical markers of organ dysfunction, and increase survival rates [15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Serum melatonin levels are associated with mortality in severe septic patients

Lorente

Martı́n

Abreu-González

et al. 2015

Journal of Critical Care

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“…Deletion of melatonin receptors in experimental sepsis generated a greater inflammatory response in mice (32). Exogenous melatonin increased survival of sepsis in a melatonin receptor-dependent fashion (33).…”

Section: Circadian Rhythm and Sepsismentioning

confidence: 99%

Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer

et al. 2016

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Physiological and cellular functions operate in a 24-hour cyclical pattern orchestrated by an endogenous process known as the circadian rhythm. Circadian rhythms represent intrinsic oscillations of biological functions that allow for adaptation to cyclic environmental changes. Key clock genes that affect the persistence and periodicity of circadian rhythms include BMAL1/CLOCK, Period 1, Period 2, and Cryptochrome. Remarkable progress has been made in our understanding of circadian rhythms and their role in common medical conditions. A critical review of the literature supports the association between circadian misalignment and adverse health consequences in sepsis, obstructive lung disease, obstructive sleep apnea, and malignancy. Circadian misalignment plays an important role in these disease processes and can affect disease severity, treatment response, and survivorship. Normal inflammatory response to acute infections, airway resistance, upper airway collapsibility, and mitosis regulation follows a robust circadian pattern. Disruption of normal circadian rhythm at the molecular level affects severity of inflammation in sepsis, contributes to inflammatory responses in obstructive lung diseases, affects apnea length in obstructive sleep apnea, and increases risk for cancer. Chronotherapy is an underused practice of delivering therapy at optimal times to maximize efficacy and minimize toxicity. This approach has been shown to be advantageous in asthma and cancer management. In asthma, appropriate timing of medication administration improves treatment effectiveness. Properly timed chemotherapy may reduce treatment toxicities and maximize efficacy. Future research should focus on circadian rhythm disorders, role of circadian rhythm in other diseases, and modalities to restore and prevent circadian disruption.

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Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis

Abstract: Melatonin receptors mediate improvements of survival after polymicrobial sepsis in rats and mice; this effect appears to be independent from major alterations of cytokine release.

Cited by 52 publications

References 39 publications

Action of Melatonin on Severe Acute Liver Failure in Rats

Action of Melatonin on Severe Acute Liver Failure in Rats

Serum melatonin levels are associated with mortality in severe septic patients

Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer

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