Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

Liu, Kaiqing; Yu, Wensai; Wei, Wei; Zhang, Xinbao; Tian, Ye; Melak, Sherif; Liu, Xin; Dong, Chao; Wu, Wangjun; Zhang, Lifan; Chen, Jie

doi:10.1194/jlr.m087619

Cited by 53 publications

(43 citation statements)

References 51 publications

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“…A similar change in the growth of lipid droplets number in each cell was observed in HCD ZT01, HCD ZT11, and HCD water compared to that in HCD amount by 67 %, 2.8-fold (have reached control level), and 3.5-fold (more than control by 17 %), respectively. This shift in beige adipocyte morphology after melatonin use can be associated with an increased functional activity of thermogenesis, mitochondrial biogenesis, and lipolysis, as shown in vivo (Liu et al, 2019) and in vitro (Kato et al, 2015) in previous studies.…”

Section: Resultssupporting

confidence: 65%

Variable Beige Adipocyte Morphology in Obese Rats by Different Times of Melatonin Administration

et al. 2020

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This study aimed to evaluate changes in beige adipocytes at different times of melatonin administration, in the morning (ZT01) or in the evening (ZT11), at 30 mg/kg daily by gavage for 7 weeks or continuously with drinking water in the term of high-calorie diet-induced obesity (HCD). Melatonin received at ZT11 or with drinking water resulted in an increased area of the browning zone in the subcutaneous white adipose tissue (sWAT), even in rats with HCD (compared with Control or HCD, respectively). The beige adipocyte and lipid droplet area after melatonin use were reduced compared to those with HCD and Control, in all administration modes (group ZT01 showed smaller changes compared to ZT11 or with drinking water groups). The fibrosis level decreased and significantly differed in HCD ZT01, HCD ZT11, and HCD water compared to that in HCD; moreover, the lowest value determined in HCD water, reached the control parameters. Furthermore, the IL-1b and IL-8 level was decreased in the HCD groups under melatonin treatment at ZT11 or with drinking water compared to that in HCD. The obtained results suggest that melatonin promotes sWAT browning in rats with diet-induced obesity and influences morphological signs of normal rats depending on the time of administration. Different functional activity of beige adipocytes was observed after melatonin was used depending on the time of administration, resulting in heat production and lipolysis (the relative mass of visceral fat was likewise diminished). More rapid browning was observed when melatonin treatment was performed at 1 h before lights-off (ZT11) or continuously via drinking water. Melatonin acted on beige adipocytes of obese rats through changing some parameters such as the area of adipocytes and lipid drops, the number of lipid drops, the relative area browning of sWAT, and the level of tissue fibrosis.

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Section: Resultssupporting

confidence: 65%

Variable Beige Adipocyte Morphology in Obese Rats by Different Times of Melatonin Administration

et al. 2020

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“…Another interesting property of a single melatonin dose (2.5 mg) is to reduce rectal temperature during intermittent exercise in a hot environment without any alertness [193]. Independently from physical training, Liu et al reported that melatonin (20 mg/kg) intravenously administered for four weeks enhanced lipolysis in mice vastus lateralis muscle by activating the "browning" effect in the adipose tissue and thermogenesis [194].…”

Section: Impact Of Melatonin On Skeletal Muscle Activity and Exercisementioning

confidence: 99%

Impact of Melatonin on Skeletal Muscle and Exercise

Stacchiotti

Favero

Rodella

2020

Cells

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Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression of muscle frailty include nutrition and physical training. Melatonin, the indole produced at nighttime in pineal and extra-pineal sites in mammalians, has recognized anti-aging, anti-inflammatory, and anti-oxidant properties. Mitochondria are the favorite target of melatonin, which maintains them efficiently, scavenging free radicals and reducing oxidative damage. Here, we discuss the most recent evidence of dietary melatonin efficacy in age-related skeletal muscle disorders in cellular, preclinical, and clinical studies. Furthermore, we analyze the emerging impact of melatonin on physical activity. Finally, we consider the newest evidence of the gut–muscle axis and the influence of exercise and probably melatonin on the microbiota. In our opinion, this review reinforces the relevance of melatonin as a safe nutraceutical that limits skeletal muscle frailty and prolongs physical performance.

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“…Melatonin treatment has also been shown to reduce fat mass (and percentage of body fat) with a concomitant increase of lean mass in postmenopausal women following 1 year of treatment compared to placebo (13). Studies now suggest that melatonin treatment may stimulate lipolysis through the activation of the sympathetic nervous system, as well as stimulate intramuscular adipocyte lipolysis via activation of both extracellular signal-regulated kinase (ERK) 1/2 and protein kinase A (PKA) signaling (14, 15). Taken together, these studies begin to demonstrate a potential role for melatonin in modulating body weight, specifically through its regulation of fat mass.…”

Section: Melatonin As a Regulator Of Metabolism And Body Weightmentioning

confidence: 99%

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

et al. 2019

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Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions. In addition to its rather well-established roles in the regulation of circadian rhythms, sleep, and reproduction, melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that disruption of melatonin receptors signaling may contribute to the pathogenesis of type 2 diabetes, although the exact mechanisms underlying its action remain unclear. Additionally, a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy balance. This review summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism.

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Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

Cited by 53 publications

References 51 publications

Variable Beige Adipocyte Morphology in Obese Rats by Different Times of Melatonin Administration

Variable Beige Adipocyte Morphology in Obese Rats by Different Times of Melatonin Administration

Impact of Melatonin on Skeletal Muscle and Exercise

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

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