Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injury

Taysı, Seyithan; Memişoğulları, Ramazan; Koç, Mehmet; Yazıcı, Ahmet; Aslankurt, Murat; Gümüştekin, Kenan; Al, Behçet; Ozabacigil, Fatma; Yılmaz, Adnan; Özder, H. Tahsin

doi:10.1080/09553000802390932

Cited by 54 publications

(70 citation statements)

References 32 publications

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“…[2612] But, cataract is an unavoidable complication if radiotherapy includes the orbit of eye in the treated volume, even with very low doses of radiation. Ionizing radiation, such as X and gamma rays and ultraviolet lights, is known to be a cataractogenic factor for rat lenses.…”

Section: Discussionmentioning

confidence: 99%

“…The speed at which a response develops varies widely from one tissue to another and often depends on the dose of radiation that the tissue received. [12] Ionizing radiation is known to generate reactive oxygen species (ROS) in irradiated tissue. Because human body contains 80% water, the major radiation damage is due to the aqueous free radicals, generated by the action of radiation on water.…”

Section: Introductionmentioning

confidence: 99%

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Zinc administration modulates radiation-induced oxidative injury in lens of rat

et al. 2012

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Background:The aim of this study was to evaluate the antioxidant role of zinc (Zn) against radiation-induced cataract in the rat lens after total cranial irradiation with a single 5 Gray (Gy) dose of gamma irradiation.Materials and Methods:Twenty-one Sprague-Dawley rats were used for the experiment. The control group did not receive Zn or irradiation but received 1-ml saline orally plus sham-irradiation. The irradiation (IR) group received 5 Gy gamma irradiation to the total cranium as a single dose plus 0.1 ml physiological saline intraperitoneally. The IR plus Zn group received irradiation to total cranium plus 10 mg/kg/day Zn intraperitoneally. Biochemical parameters measured in rat lenses were carried out using spectrophotometric techniques.Results:Lens total (enzymatic plus non-enzymatic) superoxide scavenger activity (TSSA), glutathione reductase (GRD), and glutathione-S-transferase (GST) activities significantly increased in the IR plus Zn groups when compared with the IR group. However, TSSA, GRD and GST activities were significantly lower in the IR group when compared with the control group. Lens non-enzymatic superoxide scavenger activity (NSSA) in the IR plus Zn group was significantly increased compared to that of the IR group. Lens xanthine oxidase (XO) activity in the IR group significantly increased compared to that of both the control and IR plus Zn groups.Conclusion:Zn has clear antioxidant properties and prevented oxidative stress by scavenging free radicals generated by ionizing radiation in rat lenses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc administration modulates radiation-induced oxidative injury in lens of rat

et al. 2012

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“…Besides the animal models of AD and PD discussed below, melatonin has been shown to lower neural damage due to cadmium toxicity (Poliandri et al 2006 ;Jimenez-Ortega et al 2011 ), hyperbaric hyperoxia (Shaikh et al 1997 ;Pablos et al 1997 ), δ-aminolevulinic acid toxicity (Princ et al 1997 ;Carneiro and Reiter 1998 ;Onuki et al 2005 ), γ radiation (Erol et al 2004 ;Shirazi et al 2011 ;Taysi et al 2008 ), focal ischemia (Lee et al 2004 ;Tai et al 2011 ), brain trauma (Beni et al 2004 ;Tsai et al 2011 ;Kabadi and Maher 2010 ), and a number of neurotoxins (Reiter et al 2010 ).…”

Section: Basic Biology Of Melatonin Relevant To Neurodegenerationmentioning

confidence: 97%

Therapeutical Implications of Melatonin in Alzheimer’s and Parkinson’s Diseases

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et al. 2015

Molecular and Integrative Toxicology

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Neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD) are major health problems, and a growing recognition exists that efforts to prevent them must be undertaken by both governmental and nongovernmental organizations. In this context, the pineal product melatonin has a promising signifi cance because of its chronobiotic/cytoprotective properties. One of the features of advancing age is the gradual decrease in endogenous melatonin synthesis. A limited number of therapeutic trials have indicated that melatonin has a potential therapeutic value as a neuroprotective drug in the treatment of AD, minimal cognitive impairment (which may evolve to AD), and PD. Both in vitro and in vivo, melatonin prevented the neurodegeneration seen in experimental models of AD and PD. For these effects to occur, doses of melatonin about two orders of magnitude higher than those required to affect sleep and circadian rhythmicity are needed. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100 mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.

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“…Several studies have suggested that intake of antioxidant-rich foods may slow the progression of cataract. Therefore, to date, a number of antioxidant chemicals and drugs such as L-carnitine, acetyl-L-carnitine, lycopene, melatonin, resveratrol, α-lipoic acid, Ginkgo biloba, α-tocopherol, N-acetylcysteine, pyruvate and verapamil have been used to prevent experimental cataract in the lens (11,12,14,15,(18)(19)(20)(21)(22)(23)(24)(25). They were found to be effective in preventing cataract, but none have been implemented in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…L-carnitine, melatonin, Ginkgo biloba, vitamin E, estrogen, metalloporphyrin and verapamil protected irradiation-induced cataract development by virtue of their antioxidant properties (2,11,12,16,17,19,22,23,40,41). The investigators measured MDA and the antioxidant enzyme levels such as SOD, catalase, total antioxidant in the lens tissues and graded the lens opacification.…”

Section: Discussionmentioning

confidence: 99%