Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin, Jie; Li, Yuying; Han, Hui; Chen, Shuai; Gao, Jing; Liu, Gang; Wu, Xin; Deng, Jinping; Yu, Qifang; Huang, Xingguo; Fang, Rejun; Li, Tiejun; Reíter, Russel J.; Zhang, Dong; Zhu, Congrui; Zhu, Guoqiang; Ren, Wenkai; Yin, Yulong

doi:10.1111/jpi.12524

Cited by 331 publications

(330 citation statements)

References 70 publications

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“…Previous studies have also associated changes in dietary habits (particularly the adoption of a HFD) with gut microbiota dysbiosis, which suggests clear consequences in terms of metabolic disorders (Chen et al ; Yin et al ). Along with the above‐mentioned positive effects of dietary quercetin on metabolic and immune responses, this study also revealed the beneficial impacts of quercetin on dysbiosis in mice fed a HFD.…”

Section: Discussionmentioning

confidence: 99%

“…statins) are associated with a reduced risk of CVD (Abbott et al ). Intestinal inflammation has also been linked to alterations in lipid metabolism caused by the gut microbiota (Cavalcante‐Silva et al ; Xu et al ; Yin et al ), and a correlation has been identified between atherosclerosis and dietary trimethylamine metabolism in the gut microbiota (Tang and Hazen ).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

et al. 2019

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Aims Epidemiological studies have correlated cardiovascular disease and atherosclerosis with lifestyle factors such as sedentary behaviour and a high‐calorie diet. Recent studies of pathogenesis have highlighted the significance of the intestinal microbiota and chronic inflammation with respect to both the onset and development of atherosclerosis. This study examined the hypothesis that the oral administration of quercetin to low‐density lipoprotein receptor‐null (Ldlr−/−) mice would improve gut health by altering the gut microbiota and controlling the levels of atherogenic lipid metabolites and proinflammatory mediators in the intestine and serum. Methods and Results Mice were maintained on a high‐fat diet with or without oral quercetin administration for 12 weeks. Quercetin treatment suppressed body weight gains and reduced the extent of atherosclerotic lesions in the aortic sinus. Reduced malondialdehyde and increased interleukin 6 levels further indicated the protective effect of quercetin against immune/inflammatory responses and oxidative stress. Furthermore, quercetin led to decreased intestinal levels of cholesterol, lysophosphatidic acids and atherogenic lysophosphatidylcholine (LPC 18:1) and an increased level of coprostanol. A phylum‐level microbial analysis revealed that quercetin treatment reduced the abundance of Verrocomicrobia and increased microbiome diversity and the abundances of Actinobacteria, Cyanobacteria and Firmicutes. A Spearman analysis revealed negative correlations of Actinobacteria with intestinal and plasma LPC 18:1 and caecal cholesterol levels and of Firmicutes and Cyanobacteria with the plasma LPC 18:1 level. Conclusions This study demonstrated the ability of quercetin treatment to reduce lipid levels, as well as the areas of atherosclerotic lesions and sizes of plaques. This treatment also altered the composition of the gut microbiota and decreased the levels of atherogenic lipid metabolites. Significance and Impact of the Study Oral quercetin treatment may represent a new approach to mitigating the onset and development of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

et al. 2019

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“…Yin et al have demonstrated that HFD decreases gut microbiota diversity in mice, and melatonin administration (108 mg/kg daily for 2 weeks, supplemented in drinking water) improved this diversity as well as liver steatosis in HFD mice . In this model, HFD altered the mouse gut microbiota balance by elevating abundance of Lactobacillus and decreasing abundance of Bacteroides , which was also observed in cholangiopathies and may be associated with liver damage and fibrosis, and melatonin reversed these effects . Although further studies are required, melatonin administration may be a promising therapeutic tool for NAFLD by improving mitochondrial activities, inhibiting lipid accumulation in the liver, and maintaining gut microbiota diversity.…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 94%

“…Gut microbiota is associated with the pathophysiology of NAFLD, and gut bacteria transplantation has potential therapeutic effects to improve liver conditions . Yin et al have demonstrated that HFD decreases gut microbiota diversity in mice, and melatonin administration (108 mg/kg daily for 2 weeks, supplemented in drinking water) improved this diversity as well as liver steatosis in HFD mice . In this model, HFD altered the mouse gut microbiota balance by elevating abundance of Lactobacillus and decreasing abundance of Bacteroides , which was also observed in cholangiopathies and may be associated with liver damage and fibrosis, and melatonin reversed these effects .…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 94%

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

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Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhythms and expressions as well as melatonin production. Previous studies indicate the association between circadian rhythms with various liver diseases, and disruption of rhythms or clock gene expression may promote liver steatosis, inflammation, or cancer development. It is well known that melatonin has strong antioxidant effects. Alcohol drinking or excess fatty acid accumulation produces reactive oxygen species and oxidative stress in the liver leading to liver injuries. Melatonin administration protects these oxidative stress‐induced liver damage and improves liver conditions. Recent studies have demonstrated that melatonin administration is not limited to antioxidant effects and it has various other effects contributing to the management of liver conditions. Accumulating evidence suggests that restoring circadian rhythms or expressions as well as melatonin supplementation may be promising therapeutic strategies for liver diseases. This review summarizes recent findings for the functional roles and therapeutic potentials of circadian rhythms and melatonin in liver diseases.

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“…The mammalian gastrointestinal tract harbours a complex and diverse microbial community, which plays crucial roles in host digestion, metabolism, immune function and redox balance (Turnbaugh et al ; Hooper et al ; Karlsson et al ; Zhang et al ; Yin et al ). Early life colonization and development of the gut microbiota in neonates highly shapes the host’s metabolism and health (Ottman et al ; Matamoros et al ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

Zhang

Xie

et al. 2019

J of Applied Microbiology

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Aim Intrauterine growth retardation (IUGR) is a prevalent problem in mammals. The present study was conducted to unveil the alterations in intestinal microbiota in IUGR piglets. Methods and Results We identified the alterations of small intestinal microbiota in IUGR piglets on 7, 21 and 28 days of age using 16S rRNA sequencing. The results showed that IUGR piglets had a decreased alpha diversity of jejunum microbiota at 7 and 21 days of age; had lower abundances of Bacteroidetes and Bacteroides in the jejunum at 7, 21 and 28 days of age, Oscillibacter in the jejunum at 21 days of age, and Firmicutes in the ileum at 21 days of age; whereas they had higher abundances of Proteobacteria and Pasteurella in the ileum at 21 days of age and Escherichia–Shigella in the jejunum at 28 days of age. Correlation analysis showed that Bacteroides, Oscillibacter and Ruminococcaceae_UCG‐002 compositions were positively associated with the body weight (BW) of IUGR piglets, nevertheless Proteobacteria and Escherichia–Shigella relative abundances were negatively correlated with the BW of IUGR piglets. Gene function prediction analysis indicated that microbiota‐associated carbohydrate metabolism, lipid metabolism, glycan biosynthesis and metabolism, amino acid metabolism, and xenobiotics biodegradation and metabolism were downregulated in the IUGR piglets compared to control piglets. Conclusions The present study profiled the intestinal microbiota of newborn piglets with IUGR and the newborn IUGR piglets have lower diversity and different taxonomic abundances. Alterations in the abundances of Bacteroidetes, Bacteroides, Proteobacteria Escherichia–Shigella and Pasteurella may be involved in nutrient digestion and absorption, as well as the potential mechanisms connecting to the growth and development of IUGR in mammals. Significance and Impact of the Study The small intestinal microbiota were highly shaped in the IUGR piglets, which might further mediate the growth and development of IUGR piglets; and the gut microbiota could serve as a potential target for IUGR treatment.

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Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Cited by 331 publications

References 70 publications

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

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