Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking

Mishima, Kazuo; Tozawa, Tozawa; Satoh, Kohtoku; Matsumoto, Yasuhiro; Hishikawa, Yasuo; Okawa, Masako

doi:10.1016/s0006-3223(97)00510-6

Cited by 243 publications

(156 citation statements)

References 22 publications

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“…Early neuropathological changes in preclinical AD stages are accompanied by decreased levels of melatonin (Tohgi et al, 1992) and correlated significantly with the severity of mental and sleep impairments in demented patients (Mishima et al, 1999). The loss of melatonin may exacerbate the disruption of the sleep–wake rhythm, and exogenously administered melatonin may in principle mitigate the loss and improve the restorative value of sleep.…”

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

571

350

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In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order. The SCN‐activated, light‐inhibited production of melatonin conveys the message of darkness to the clock and induces night‐state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo‐controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm‐related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non‐restorative) sleep quality, non‐dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). The diminished production of melatonin at the very early stages of AD, the role of melatonin in the restorative value of sleep (perceived sleep quality) and its sleep‐anticipating effects resulting in attenuated activation of certain brain networks are gaining a new perspective as the role of poor sleep quality in the build‐up of β amyloid, particularly in the precuneus, is unravelled. As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc

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Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

571

350

View full text Add to dashboard Cite

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“…Melatonin secretion by the pineal gland is known to decline by age and, even more profoundly, in various age-related pathologies, in particular, neurodegenerative diseases, and in the complex of metabolic syndrome and type 2 diabetes [51,[77][78][79]. Therefore, it will be of utmost importance to study in detail and on a broader scale the changes that can be induced by melatonin in aging mammals, as far as possible, including the human.…”

Section: Resultsmentioning

confidence: 99%

“…A rhythm of Bmal1 methylation was described and also deviations of this rhythm were observed in brain tissue from early stages of Alzheimer's disease (AD). Circadian deviations are known in AD, but have previously mainly been seen under the aspect of progressive neurodegeneration [51,52]. With this new information, one might be inclined to consider earlier prodromal changes by epigenetic modulation.…”

Section: Circadian Oscillators and Melatonin In The Context Of Dna Momentioning

confidence: 99%

Future Demands Concerning the Epigenetic Relevance of Melatonin and the Circadian System in Gerontology

Hardeland¹

2017

J Geriatr Med Gerontol

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Melatonin is a highly pleiotropic regulator molecule that influences numerous functions in many cell types. Its actions comprise direct and circadian oscillator-mediated effects. The levels of circulating melatonin typically decline in the course of aging. Additionally,various aging-associated diseases further decrease melatonin concentrations. With regard to its remarkably broad spectrum of actions, control mechanisms upstream and downstream of melatonin should be investigated much more in detail with regard to the contribution of epigenetic modulation. The importance of epigenetic alterations has already become evident in the fields of both gerontology and chronobiology. Therefore, it seems necessary to fill the gaps concerning corresponding processes related to melatonin, especially under the aspects of physiologic malfunctions because of aging-associated decreases of melatonin. This review outlines the findings on melatonin's epigenetic actions, as obtained to date, and sets these results in correspondence to general knowledge and many specific findings concerning circadian rhythms. These considerations focus on DNA methylation and erasure of 5-methylcytosine, on histone modification, in particular, acetylation/deacetylation and methylation/demethylation, and on the manifold roles of noncoding RNAs, especially microRNAs. With regard to melatonin's spectrum of actions in the gerontological context, emphasis is given to its contribution to circadian oscillation amplitudes, to anti-inflammatory actions and to antioxidative protection.

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“…The blood melatonin level gradually decreases during the night with age and this decrease is more profound in the elderly [23]. In AD patients, a decreased melatonin level compared with normal elderly subjects is observed in the cerebrospinal fluid, as well as in the blood [24][25][26]. Melatonin is known to penetrate the brain-blood barrier and function as an antioxidant and a free radical scavenger.…”

Section: Association Of Ad and Sleep Disordersmentioning

confidence: 99%

Circadian Rhythm Sleep Disorder in Alzheimer’s Disease-A consideration in relation with the Neuropathological and Neuroendocrinal alternation

Umetsu¹,

Fukumoto

Sakurai³

et al. 2014

Brain Disord Ther

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The Circadian rhythm sleep disorder of the dementia is apt to cause night wandering, delirium and even sundowning syndrome. And these behaviors put a major burden on the patients themselves and their caregivers. The ratio of complication of Circadian rhythm sleep disorder in Alzheimer's disease, the major figure of dementia, is considerably high. Circadian rhythm sleep disorder in Alzheimer's disease is supposed to be caused by physiological change of the internal secretion rhythm, physical disorder and/or environmental factors. Furthermore, in recent years, in addition to the high rate of coexistence, it has been reported that there may be essential relation between circadian rhythm sleep disorder and Alzheimer's disease. In the present study, we summarized the role of neuropathological and neuroendocrinal alternation in Circadian rhythm sleep disorder of Alzheimer's disease.

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Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking

Cited by 243 publications

References 22 publications

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Future Demands Concerning the Epigenetic Relevance of Melatonin and the Circadian System in Gerontology

Circadian Rhythm Sleep Disorder in Alzheimer’s Disease-A consideration in relation with the Neuropathological and Neuroendocrinal alternation

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