Melatonin supplement induced the hair follicle development in offspring rex rabbits

Bai

et al. 2021

Poultry Science

This study investigated whether dietary resistant potato starch ( RPS ) inclusion could ameliorate the negative impact of a low nonphytate phosphorus ( nPP ) diet on growth performance, feather growth, feather follicles ( FF ) development, and carcass traits by improving nutrient utilization and cecal microbiome fermentation capacity in Pekin ducks. The experiment was performed with a 2 × 2 randomized block design with 2 levels of RPS (0 or 12%) and 2 levels of nPP (low or normal, low: 0.22% at 1–14 d and 0.18% at 15–35 d of age; normal: 0.40% at 1–14 d and 0.35% at 15–35 d of age) for a total of 4 treatments, each with 8 replicate pens per treatment of 12 birds per pen. As regards growth performance and carcass traits, RPS inclusion markedly increased ( P < 0.05) BW of 14 and 35 d, BWG and FI of 1–14 d, 15–35 d, and 1–35 d as well as abdominal fat and breast meat percentage of 35 d in ducks fed low nPP diets; moreover, RSP inclusion significantly reduced ( P < 0.05) mortality in ducks fed low nPP diets. As regards feather growth and follicles development of 35 d, RPS inclusion significantly increased ( P < 0.05) the fourth primary feather length, absolute feather weight, and the density of primary FF in the back skin in ducks fed low nPP diets. In regard to nutrition utilization, RPS supplementation significantly increased ( P < 0.05) the availability of DM, CP, and energy, as well as dietary AME at 35 d of age in ducks fed low nPP diets. However, RPS supplementation had no effect ( P > 0.05) on the concentration of cecal short-chain fatty acids and the activities of cecal phytase and cellulase in ducks fed low nPP diets. These results indicate that RPS can improve nutrient availability to ameliorate the negative effects on performance and feather development caused by a low nPP diet in Pekin ducks.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary resistant potato starch improves growth performance and feather development in Pekin ducks fed a low phosphorus diet

Bai

et al. 2021

Poultry Science

“…Effects of melatonin on the hair follicle have been repeatedly described, e.g., in cashmere goats [77] and rabbits [78], but the interest was mostly focused on hair growth and not so much on differentiation. In the Cashmere goat, a seasonal breeder that produces a valuable fur, the influence of melatonin on hair growth is likely, from a fundamental point of view, as it is related to the formation of winter fur.…”

Section: Hair Follicle Stem Cells: a Lesson On Dose Conditionality An...mentioning

confidence: 99%

Melatonin and the Programming of Stem Cells

Hardeland

2022

IJMS

Melatonin interacts with various types of stem cells, in multiple ways that comprise stimulation of proliferation, maintenance of stemness and self-renewal, protection of survival, and programming toward functionally different cell lineages. These various properties are frequently intertwined but may not be always jointly present. Melatonin typically stimulates proliferation and transition to the mature cell type. For all sufficiently studied stem or progenitor cells, melatonin’s signaling pathways leading to expression of respective morphogenetic factors are discussed. The focus of this article will be laid on the aspect of programming, particularly in pluripotent cells. This is especially but not exclusively the case in neural stem cells (NSCs) and mesenchymal stem cells (MSCs). Concerning developmental bifurcations, decisions are not exclusively made by melatonin alone. In MSCs, melatonin promotes adipogenesis in a Wnt (Wingless-Integration-1)-independent mode, but chondrogenesis and osteogenesis Wnt-dependently. Melatonin upregulates Wnt, but not in the adipogenic lineage. This decision seems to depend on microenvironment and epigenetic memory. The decision for chondrogenesis instead of osteogenesis, both being Wnt-dependent, seems to involve fibroblast growth factor receptor 3. Stem cell-specific differences in melatonin and Wnt receptors, and contributions of transcription factors and noncoding RNAs are outlined, as well as possibilities and the medical importance of re-programming for transdifferentiation.

“…Following subcutaneous melatonin implantation, hair follicle development in newborn goats is significantly increased (Yang et al, 2019a). Melatonin boosts cashmere production by altering the hair growth cycle and structure (O'Neill et al, 1992;Duan et al, 2015;Ge et al, 2018;Feng and Gun, 2021). It has also been shown that, in vitro, melatonin enhances the elongation of cashmere hair shafts by promoting the proliferation of hair follicle stem cells (Ge et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The Wnt pathway is essential to the initiation of hair growth (Andl et al, 2002;Zhang et al, 2009;Feng and Gun, 2021), and transmits signals among many types of stem cells during the formation of hair placodes (Zhang et al, 2009). Catenin beta-1 (CTNNB1), a downstream signal molecule in the Wnt pathway, is an essential factor in deciding hair follicle stem cell fate and mediating the formation of follicular keratinocytes (Huelsken et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Wang

et al. 2021

Front. Cell Dev. Biol.

Emerging studies show that melatonin promotes cashmere development through hypodermic implantation. However, the impact and underlying mechanisms are currently unknown. In vitro study has previously demonstrated that melatonin induces cashmere growth by regulating the proliferation of goat secondary hair follicle stem cells (gsHFSCs), but there is limited information concerning the effects of melatonin on cell pluripotency. It is also known that Wnt signaling may actively participate in regulating cell proliferation and stem cell pluripotency. Therefore, in the current investigation, goat hair follicle stem cells were exposed to multiple concentrations of melatonin and different culture times to reveal the relationship between melatonin and the activation of Wnt signaling. A proportionally high Catenin beta-1 (CTNNB1) response was induced by 500 ng/L of melatonin, but it was then suppressed with the dosages over 1,000 ng/L. Greater amounts of CTNNB1 entered the cell nuclei by extending the exposure time to 72 h, which activated transcription factor 4/lymphoid enhancer-binding factor 1 and promoted the expression of the proliferation-related genes C-MYC, C-JUN, and CYCLIND1. Moreover, nuclear receptor ROR-alpha (RORα) and bone morphogenetic protein 4 (BMP4) were employed to analyze the underlying mechanism. RORα presented a sluggish concentration/time-dependent rise, but BMP4 was increased dramatically by melatonin exposure, which revealed that melatonin might participate in regulating the pluripotency of hair follicle stem cells. Interestingly, NOGGIN, which is a BMP antagonist and highly relevant to cell stemness, was also stimulated by melatonin. These findings demonstrated that melatonin exposure and/or NOGGIN overexpression in hair follicle stem cells might promote the expression of pluripotency markers Homeobox protein NANOG, Organic cation/carnitine transporter 4, and Hematopoietic progenitor cell antigen CD34. Our findings here provided a comprehensive view of Wnt signaling in melatonin stimulated cells and melatonin mediated stemness of gsHFSCs by regulating NOGGIN, which demonstrates a regulatory mechanism of melatonin enhancement on the growth of cashmere.