Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model

Alamili, Mahdi; Bendtzen, Klaus; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenur, Ismail

doi:10.1016/j.jcrc.2013.09.006

Cited by 50 publications

(35 citation statements)

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“…Finally, it can restore mitochondrial production of ATP [115]. When healthy volunteers received melatonin before the administration of LPS, several markers of inflammation and oxidative stress were reduced [116]. In another study, melatonin treatment in septic newborns resulted in lower concentrations of lipid peroxidation products and other favorable outcomes [117].…”

Section: Nos Inhibitorsmentioning

confidence: 99%

Role of Mitochondrial Oxidative Stress in Sepsis

2018

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Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant. Selenium, vitamin C, and 3N-acetylcysteine among others are potential therapies for the restoration of redox balance in sepsis. Results from recent studies are promising, but there is a need for more human studies in a clinical setting for safety and efficiency evaluation.

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Section: Nos Inhibitorsmentioning

confidence: 99%

Role of Mitochondrial Oxidative Stress in Sepsis

2018

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“…These are, but not limited to, the fact that melatonin suppresses the levels of TNF-a, IFN-a, IL6, IL8, TF, MCP-1, VEGF, phosphorylation of JNK, and the degradation of the tight junctional proteins and it reduces endothelial apoptosis [13][14][15] Protecting against endothelial cell injury and preserving vascular structure and function are important to avoid the deadly hemorrhage in late stage EVD.…”

Section: Melatonin and Its Potential Effects On Ebola Pathologymentioning

confidence: 99%

Ebola virus disease: potential use of melatonin as a treatment

Tan

Korkmaz

Reíter

et al. 2014

Journal of Pineal Research

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The purpose of this report is to emphasize the potential utility for the use of melatonin in the treatment of individuals who are infected with the Ebola virus. The pathological changes associated with an Ebola infection include, most notably, endothelial disruption, disseminated intravascular coagulation and multiple organ hemorrhage. Melatonin has been shown to target these alterations. Numerous similarities between Ebola virus infection and septic shock have been recognized for more than a decade. Moreover, melatonin has been successfully employed for the treatment of sepsis in many experimental and clinical studies. Based on these factors, as the number of treatments currently available is limited and the useable products are not abundant, the use of melatonin for the treatment of Ebola virus infection is encouraged. Additionally, melatonin has a high safety profile, is readily available and can be orally self-administered; thus, the use of melatonin is compatible with the large scale of this serious outbreak.

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“…However, melatonin in septic patients has been scarcely explored and only in studies of small sample size (maximum 20 patients) [24][25][26][27][28][29][30]. In one study of 14 septic patients was found a negative correlation between Acute Physiology and Chronic Health Evaluation II (APACHE II) scores and serum melatonin levels [28].…”

Section: Introductionmentioning

confidence: 99%