Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation

Kikuchi, Masatoshi; Kadena, Miki; Fukamachi, Hiromi; Takaki, Takashi; Matsui, Shohei; Hoashi-Takiguchi, Sumire; Morisaki, Hirobumi; Trtić, Nataša; Mori, Mina; Kurosawa, Mie; Itsumi, Momoe; Funatsu, Takahiro; Sakurai, Atsuo; Shintani, Seikou; Kato, Hiroki; Fujita, Takashi; Maruoka, Yasubumi; Kuwata, Hirotaka

doi:10.1016/j.heliyon.2022.e11149

Cited by 1 publication

(2 citation statements)

References 38 publications

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“…Encephalomyocarditis virus, a small non‐enveloped single‐strand RNA virus, causes inflammation of both the heart and of the brain but in some species, complications may include reproductive disorders and diabetes. Kikuchi et al 21 found that melatonin in vitro attenuated the uptake of viral particles into RAW264‐7 macrophages and suppressed cytoskeletal regulation in the innate immune system. In an accompanying in vivo infection experiment, melatonin given in the drinking water of BALB/c mice for 3 days after infection with the virus led to partial exacerbation of the infection in the brain.…”

Section: Resultsmentioning

confidence: 99%

“…Encephalomyocarditis virus, a small non-enveloped single-strand RNA virus, causes inflammation of both the heart and of the brain but in some species, complications may include reproductive disorders and diabetes. Kikuchi et al 21 JEV infection in SH-SY5Y cells (Figure 3). 22 While JEV infections are readily prevented with an appropriate vaccine, the observations of Kitidee et al 22 this may be a mechanism by which melatonin inhibits the Zika infection.…”

Section: High Riskmentioning

confidence: 94%

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Assessing the antiviral potential of melatonin: A comprehensive systematic review

Alomari,

Al‐Abdallat,

Hamamreh

et al. 2023

Reviews in Medical Virology

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This review assesses the antiviral potential of melatonin through comprehensive analysis of studies across human subjects, animal models, cell cultures, and in‐silico simulations. The search strategy targeted relevant research until 22 June 2023, resulting in 20 primary studies after screening and deduplication. The findings highlight strong evidence supporting antiviral properties of melatonin. In silico studies identify melatonin as a candidate against SARS‐CoV‐2, reducing cytokine storm‐related respiratory responses. Cell culture experiments reveal its multifaceted effects on different viruses including respiratory syncytial virus, anti‐dengue virus, transmissible gastroenteritis virus, and encephalomyocarditis virus. Animal studies show melatonin reduces mortality and viral replication in various infections such as Venezuelan equine encephalomyelitis and COVID‐19. Clinical trials show how it could be evaluated, but with no conclusive evidence of efficacy and safety so far from large, double‐blind placebo‐controlled trials. These insights showcase the potential of melatonin as a versatile antiviral agent with immunomodulatory, antioxidant, anti‐inflammatory and antiviral properties. In summary, our review highlights melatonin's promising antiviral properties across diverse settings. Melatonin's immunomodulatory and antiviral potential makes it a compelling candidate for further investigation, emphasising the need for rigorous clinical trials to establish its safety and efficacy against viral infections.

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Section: Resultsmentioning

confidence: 99%