Melatonin: therapeutic and clinical utilization

Altun, Armağan; Uğur-Altun, Betül

doi:10.1111/j.1742-1241.2006.01191.x

Cited by 193 publications

(129 citation statements)

References 114 publications

(169 reference statements)

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“…Reports have showed that melatonin decreases cell viability in a large number of cancer cell models (breast, non-small cell lung, metastatic renal cell carcinoma, skin, hepatocellular carcinoma, and brain tumors) (Petranka et al, 1999;Jung and Ahmad, 2006). There have been numerous reports on the apoptosisinducing effects of melatonin in cancer cells, unlike in the protection of healthy cells (Sainz et al, 2003;Altun and Uğur-Altun, 2007;Bejarano et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Melatonin induces antiproliferative activity through modulation of apoptoticpathway in H-ras oncogene transformed 5RP7 cells

Kaplan

Çiftçi²,

Kutlu³

2015

Turk J Biol

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IntroductionOncogenes are important factors in the carcinogenesis process. Cancer cells may demonstrate an uncontrolled proliferation due to oncogenes. Ras is one of these oncogenes, and it is responsible for cell differentiation/ proliferation. It is well known that ras mutation occurs in human tumors such as pancreatic, thyroid, and colon cancers. H-ras, K-ras, and N-ras proteins belonging to the ras family play a role in cancer diseases (Brunner et al., 2004). Thus, ras genes are effective targets for anticancer drug development (Weiwer et al., 2012). In this study, we used H-ras oncogene transformed 5RP7 cells. These cells were obtained from embryonic tissues of Rattus norvegicus and transformed by the H-ras oncogene.Melatonin (N-acetyl-5-methoxytryptamine) is a methoxyindole secretory product as a natural compound, which is produced by the pineal gland and a variety of organs (such as the retina, Harderian glands, gut, ovary, testes, or bone marrow) during the dark phase (Leon-

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Section: Introductionmentioning

confidence: 99%

Melatonin induces antiproliferative activity through modulation of apoptoticpathway in H-ras oncogene transformed 5RP7 cells

Kaplan

Çiftçi²,

Kutlu³

2015

Turk J Biol

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“…In animals, it regulates sleep (circadian rhythms) [3] and gastrointestinal (GI) functions [4] . Proton pump inhibitors (PPIs) (pantoprazole, lansoprazole, rabeprazole, esomeprazole and omeprazole) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production [5] .…”

Section: Introductionmentioning

confidence: 99%

Which is the best choice for gastroesophageal disorders: Melatonin or proton pump inhibitors?

Torres

Pereira²

2010

WJGPT

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Author contributions: Oliveira-Torres JDF is credited with valuable discussions related to patient biopsy samples, drawing of the structures, acquisition, analysis and interpretation of data (database search work in pubmed and web of science), organization of references and valuable discussions about the questions of referees; Pereira RS is credited with the main idea of chemical structure comparison between omeprazole and melatonin and the possible mechanism of action, writing of the manuscript and answers for the referees. AbstractMelatonin is used in many countries to improve sleep disorders. Melatonin is a hormone produced by the pineal gland and enterochromaffin cells which control sleep and gastrointestinal motility. Low levels of melatonin lead to gastroesophageal reflux disease (GERD). Most of patients with GERD have a sleep disorder. So, low melatonin levels is the main cause of insomnia. Beyond this, it has an inhibitory action on gastric acid secretion and seems to control the lower esophageal sphincter. Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available today. Omeprazole (one of the PPIs) and melatonin have similarities in their chemical structures. Therefore, we could consider omeprazole as a rough copy of melatonin. In this paper, we compare the advantages and disadvantages of the clinical use of melatonin and PPIs.

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“…Melatonin is produced in the pineal gland (Peter, 1983) and by a variety of peripheral cells such as bone marrow cells (Maestroni, 2001), lymphocytes and epithelial cells of most animals. It plays a role in the regulation of circadian rhythms of several biological functions (Altun and Ugur-Altun, 2007). Melatonin functions through the activation of melatonin receptors (Boutinet al, 2005) and through its role as a pervasive and powerful antioxidant (Hardeland, 2005) particularly important in the protection of nuclear and mitochondria DNA.Many animals use the daily variation in the duration and quantity of melatonin production as a seasonal clock (Lincoln and Loudon, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of daylight hours on performance of growing grasscutters

Wogar¹,

Agwunobi²,

Ubom³

2012

Global Journal of Agricultural Sciences

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The grasscutter (Thryonomysswinderianus) holdspromise as a source of increased protein for populations of Sub-Sahara African countries. It is inexpensive to feed and features the feed utilization characteristics of ruminants and monogastrics. It is nocturnal in its activities, especially feeding. This experimentwas carried out to determine the effect of daylight hours or photoperiod on growing grasscutters under intensive rearing conditions. The effect of daylight hours on growing grasscutters was determined using sixteen 8-months old femalegrasscutters. The grasscutters were separated into four groups and allotted to four treatments of varying daylight hours. The treatments included; zero (0) hours of daylight and twenty four (24) hours (6.00 am-6.00 am) of darkness (0L:24D), six antemeridiem (am) hours (6.00 am-12.00 noon) of daylight and eighteen (18) hours (12.00 noon-6.00 am) of darkness (6L(am):18D), six post-meridiem (pm) hours (12.00 noon-6.00 pm) of daylight and eighteen (18) hours (6.00 pm-12.00 noon) of darkness (6L(pm):18D) and twelve (12) hours (6.00 am-6.00 pm) of daylight and twelve (12) hours (6.00pm-6.00am) of darkness (12L:12D).Allgrasscutters were fedadiet containing 2200kilocalories metabolizable energy per kilogram (KcalME/kg) and crude protein (CP) level of 20%. Cassava root meal and wheat offalwere the main sources of energy, while soybean meal was the main source of protein in the diets. Elephant grass was fed as basal diet.The results showed thatforage, concentrate (diet) and total feed intake, and daily weight gain were significantly (P<0.05) higher under the 6 post-meridiem hours of daylight and 18 hours of darkness (6L(pm):18D) than under other conditions. It was, therefore, concluded that the optimum daylight conditions required for the rearing of growing grasscuttersare the six (6) hours of post-meridiem daylight, followed by eighteen (18) hours of darkness.

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Melatonin: therapeutic and clinical utilization

Cited by 193 publications

References 114 publications

Melatonin induces antiproliferative activity through modulation of apoptoticpathway in H-ras oncogene transformed 5RP7 cells

Melatonin induces antiproliferative activity through modulation of apoptoticpathway in H-ras oncogene transformed 5RP7 cells

Which is the best choice for gastroesophageal disorders: Melatonin or proton pump inhibitors?

Effect of daylight hours on performance of growing grasscutters

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