Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?

Jan, James E.; Fréeman, Roger D.

doi:10.1111/j.1469-8749.2004.tb00999.x

Cited by 83 publications

(26 citation statements)

References 92 publications

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“…Recommendations typically are based on case reports and open-label trials, extrapolation from the adult literature, and expert consensus (Table 1). 128 There is some evidence of abnormality of melatonin regulation in children with ASDs, 125,130 and melatonin may be effective for improving sleep onset in children with ASDs as well as children with other developmental disabilities [131][132][133][134] and otherwise healthy children with sleep/wake disorders. 135 A recent open-label study suggested that controlled-release melatonin improved sleep in a group of 25 children with ASDs and that treatment gains were maintained at 1-and 2-year follow-up, 136 but randomized, double-blind, placebo-controlled studies are needed.…”

Section: Sleep Disturbancementioning

confidence: 99%

Management of Children With Autism Spectrum Disorders

Myers¹,

Johnson²

2007

Pediatrics

922

485

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Pediatricians have an important role not only in early recognition and evaluation of autism spectrum disorders but also in chronic management of these disorders. The primary goals of treatment are to maximize the child's ultimate functional independence and quality of life by minimizing the core autism spectrum disorder features, facilitating development and learning, promoting socialization, reducing maladaptive behaviors, and educating and supporting families. To assist pediatricians in educating families and guiding them toward empirically supported interventions for their children, this report reviews the educational strategies and associated therapies that are the primary treatments for children with autism spectrum disorders. Optimization of health care is likely to have a positive effect on habilitative progress, functional outcome, and quality of life; therefore, important issues, such as management of associated medical problems, pharmacologic and nonpharmacologic intervention for challenging behaviors or coexisting mental health conditions, and use of complementary and alternative medical treatments, are also addressed.

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Section: Sleep Disturbancementioning

confidence: 99%

Management of Children With Autism Spectrum Disorders

Myers¹,

Johnson²

2007

Pediatrics

922

485

View full text Add to dashboard Cite

show abstract

“…Indeed, long-term treatment with a combination of melatonin and low doses of the 5-HT1A receptor agonist buspirone exerted a beneficial activity and few side effects in patients with acute MDD (Fava et al, 2012). It seems that the beneficial effect of melatonin treatment as an adjuvant to other antidepressants is associated with its ability to synchronize disturbed circadian rhythms in patients with depression and a deficit of melatonin secretion (Haimov et al, 1995;Garfinkel et al, 1995;Jan et al, 2001;Mittal et al, 2010;Wade et al, 2010).…”

Section: Melatonin and Depressionmentioning

confidence: 99%

The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Tchekalarova

Moyanova

Fusco

et al. 2015

Brain Research Bulletin

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Abstract\ud \ud There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle

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“…Seizure is one of the primary causes of oxidative stress that induced neuronal cell death. Recently, melatonin is discussed in relation to epileptic seizure [100][101][102]. Melatonin has been known for antioxidant as a free radical scavenger.…”

Section: Neuroprotective Effect Of Melatonin On Seizures In Autistic Fxsmentioning

confidence: 99%

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Won

Jin

Lee

et al. 2017

Preprint

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Fragile X syndrome (FXS) is the most frequent monogenic form of autism spectrum disorder (ASD). Autistic FXS is caused by loss of the fmr1 gene product, the fragile X mental retardation protein (FMRP), triggering physiological and behavioral abnormalities. It is correlated with clock components for behavioral circadian rhythm. Mutation of this gene causes the disturbances in sleep patterns and circadian behavior commonly observed in patients with autistic FXS, accompanied by frequent dysregulation of melatonin synthesis and melatonin-dependent signaling. These changes impair vigilance, learning and memory, and are also linked to autistic behavior including the abnormal anxiety response. However, although several possible causes, symptoms, and clinical features of ASD have been investigated, the correlation between an altered circadian rhythm and autistic FXS has not been extensively studied. Recent works have highlighted the impact of melatonin on the nervous, immune, and metabolic systems. Even though utilization of melatonin for sleep disorder in ASD has been considered in clinical research, further studies should be aimed at its neuroprotective role in ASD during developmental period. In this review, we focus on the regulatory circuits involved in melatonin dysregulation and circadian system disruption in those with autistic FXS. Additionally, we discuss the neuroprotective effect of melatonin intervention. This may improve neuroplasticity and physical capability. We also review the underlying molecular mechanisms, and suggest that melatonin may be a useful novel treatment for autistic FXS, countering the adverse effects of circadian variation.

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Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?

Cited by 83 publications

References 92 publications

Management of Children With Autism Spectrum Disorders

Management of Children With Autism Spectrum Disorders

The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

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