Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder

Bendz, Lisa M; Scates, Ann C

doi:10.1345/aph.1m365

Cited by 99 publications

(52 citation statements)

References 23 publications

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“…The therapeutic use of exogenous melatonin (5 mg melatonin in the evening), used to reset the timing function of the SCN, is associated with advanced sleep onset and DLMO compared to placebo in children with idiopathic chronic sleep-onset insomnia (Smits et al, 2001;Smits et al, 2003). Also in children with ADHD, melatonin administration is considered to be an effective treatment of initial SOI (Bendz and Scates, 2010). Significant improvement in sleep parameters such as sleep onset and sleep onset latency were described in both non-stimulant treated (Hoebert et al, 2009;Van Der Heijden et al, 2007) and stimulant treated (Tjon Pian Gi et al, 2003;Weiss et al, 2006) children with ADHD and insomnia.…”

Section: Melatoninmentioning

confidence: 99%

See 1 more Smart Citation

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

Imeraj

Sonuga‐Barke

Antrop

et al. 2012

Neuroscience & Biobehavioral Reviews

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and (iv) rhythmicity in neuroendocrine and neurophysiological responsiveness. On this basis, we propose a neurobiological framework to guide future study, which sees circadian effects in ADHD, along with other aspects of ADHD arousal-related deficits (e.g., cognitive energetic deficits), as being the result of dysregulated locus coeruleus function. Based on this perspective specific recommendations for future research are presented.

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Section: Melatoninmentioning

confidence: 99%

“…Although light therapy seems effective in adults with ADHD and a delayed sleep phase (Rybak et al, 2004), so far, no melatonin medication studies in this population are available. Well-designed studies to establish optimal dosing regimens for different age groups and long-term safety are needed (Bendz and Scates, 2010).…”

Section: Circadian Profiles In Adhd 26mentioning

confidence: 99%

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

Imeraj

Sonuga‐Barke

Antrop

et al. 2012

Neuroscience & Biobehavioral Reviews

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“…[18,19,32,33] Dikkat eksikliği/hiperaktivite ve uyku başlangıcında bozukluğu (sleep-onset insomnia) olan çocuk hastalar için melatonin tedavisi öne-rilmektedir. [34] Ancak bazı araştırmalarda uyku problemi yaşayan erişkin kişilerdeki melatonin düzeyinin uyku problemi olmayan kişilerden düşük olmadığı bulunmuştur. [35] Bazil ve arkadaşları dirençli epileptik hastalarda düşük melatonin düzeyleri saptamışlardır.…”

Section: Melatonin Uyku Ve Uykusuzlukunclassified

An Overview On Melatonin Hormone

Özçeli̇k¹,

Erdem²,

Bolu³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETMelatonin hormonu, son yıllarda tüm dünyada gittikçe artan bir ilgiyle araştı-rılmaktadır. Ana görevi vücudun biyolojik saatini koruyup ritmini ayarlamak olan melatonin, vücudun birçok biyolojik ve fizyolojik süreçlerinde yer alır. Hücrelerin yenilenmesi, bağışıklık siteminin güçlenmesi, uyku ritminin ve vücut ısısının düzenlenmesi diğer önemli görevleri arasındadır. Lipofilik özel-liği nedeniyle bilinen en güçlü antioksidandır. Bu özelliği sayesinde tüm vücut alanlarına ulaşabilmekte ve kan-beyin bariyerini geçebilmektedir. Uyku problemi olan kişilerde melatoninin düşük düzeyde bulunması, ilaç olarak kullanımını akla getirmektedir. Yapılan uygulamaların ardından melatoninin uyku total süresini değiştirmeden uyku kalitesini artırdığı belirlenmiştir. Ancak yaygın araştırılmasına rağmen melatoninin işlevleri halen tamamıyla bilinmemektedir. Bu nedenle melatonin ile ilgili mevcut bilgilerin gözden geçirilmesi, bu alanda araştırma yapanlara rehberlik edecektir. Anahtar Sözcükler: Melatonin, uyku, biyolojik saat, antioksidan. ABSTRACTIn recent years, there is a growing interest in melatonin all over the world. The main task of protecting the body's biological clock, which set the rhythm of melatonin, involves many biological and physiological processes of the body. Cell renewal, strengthening of the immune system and body temperature regulation are other tasks of melatonin. Melatonin, with its lipophilic property, is the most powerful antioxidant as it can reach all body areas and can easily pass the blood-brain barrier. The fact that individuals with low levels of melatonin have sleep problems lead to the consideration of melatonin as a therapeutic medicine in this field. The detailed researches have shown that melatonin can improve sleep quality without changing the total duration of sleep. Nevertheless, despite high number of researches done, the functions ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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“…Parents reported that the melatonin improved their children's daytime behavior (Hoebert et al, 2009). A literature review confirmed that children with ADHD and insomnia showed improvement in regards to sleep onset latency when taking melatonin (Bendz & Scates, 2010). However, these results are limited as there are few studies, and most of them have small sample sizes.…”

Section: Medications For Sleep Problems In Children With Adhdmentioning

confidence: 99%

ADHD and Sleep Problems in Children

Hastings¹,

Felt²

2012

Current Directions in ADHD and Its Treatment

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Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder

Abstract: Available data suggest that melatonin is a well-tolerated and efficacious treatment option for pediatric patients with chronic SOI and ADHD. Regulated melatonin products and larger, well-designed trials to establish optimal dosing regimens and long-term safety are needed.

Cited by 99 publications

References 23 publications

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

An Overview On Melatonin Hormone

ADHD and Sleep Problems in Children

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