Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish

Giacomini, Ana C.V.V.; Teixeira, Kauane H.; Marcon, Leticia; Scolari, Naiara; Bueno, Barbara W.; Genário, Rafael; Abreu, Natascha S. de; Demin, Konstantin A.; Galstyan, David S.; Kalueff, Allan V.; Abreu, Murilo S. de

doi:10.1016/j.neulet.2020.135073

Cited by 12 publications

(8 citation statements)

References 66 publications

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“…Melatonin treatment to control and to MPTP-treated embryos does not only yield a significant increase in the day/night levels of melatonin but significantly increases them at night, reestablishing the circadian rhythm. The higher increase in melatonin at night, after its administration, compared with its levels during the daytime is not easy to explain, but changes in its adsorption or its catabolism could explain these findings, even though the embryos are exposed to exogenous melatonin for 24 h. Nevertheless, 24-h melatonin exposure is a common experimental condition able to restore cognitive and endocrine deficits in chronodisrupted zebrafish [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment

et al. 2023

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Beyond sleep/wake, clock genes regulate the daily rhythms of melatonin production, motor activity, innate immunity, and mitochondrial dynamics, among others. All these rhythms are affected in Parkinson’s disease (PD), suggesting that chronodisruption may be an early stage of the disease. The aim of this study was to evaluate the connection between clock genes and these rhythms in PD, and whether melatonin administration reestablished the normal clock function. Parkinsonism was induced with 600 μM MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in 24–120 h post fertilization (hpf) zebrafish embryos and melatonin was administered at a dose of 1 μM. Day–night melatonin rhythm disappeared in MPTP-treated embryos, which showed an advance in the activity phase in parallel with changes in the rhythm of clock genes. An alteration in the fission-to-fusion mitochondrial dynamics was also detected in parkinsonian embryos, increasing the former and leading to apoptosis. Melatonin administration to MPTP-treated embryos fully restored the circadian system, including the rhythms of clock genes, motor activity, melatonin rhythm, and mitochondrial dynamics, and decreasing apoptosis. Because clock-controlled rhythms such as sleep/wake alterations are early events in PD, the data here reported may point to chronodisruption as one initial pathophysiological event of the disease.

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Section: Discussionmentioning

confidence: 99%

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment

et al. 2023

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“…Melatonin plays an important role in cognitive regulation ( Table 2 ). In zebrafish, melatonin treatment mitigates cognitive disorder, which results from altered circadian rhythm ( 47 ). In a 5-fluorouracil-induced cognitive deficits model, melatonin administration reversed rat spatial memory dysfunction ( 46 ).…”

Section: Melatonin Improves Mood and Cognitive Functionmentioning

confidence: 99%

Melatonin for premenstrual syndrome: A potential remedy but not ready

Yin

Zhang²,

Guo³

et al. 2023

Front. Endocrinol.

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Premenstrual syndrome (PMS), a recurrent and moderate disorder that occurs during the luteal phase of the menstrual cycle and quickly resolves after menstruation, is characterized by somatic and emotional discomfort that can be severe enough to impair daily activities. Current therapeutic drugs for PMS such as selective serotonin reuptake inhibitors are not very satisfying. As a critical pineal hormone, melatonin has increasingly been suggested to modulate PMS symptoms. In this review, we update the latest progress on PMS-induced sleep disturbance, mood changes, and cognitive impairment and provide possible pathways by which melatonin attenuates these symptoms. Moreover, we focus on the role of melatonin in PMS molecular mechanisms. Herein, we show that melatonin can regulate ovarian estrogen and progesterone, of which cyclic fluctuations contribute to PMS pathogenesis. Melatonin also modulates gamma-aminobutyric acid and the brain-derived neurotrophic factor system in PMS. Interpreting the role of melatonin in PMS is not only informative to clarify PMS etiology but also instructive to melatonin and its receptor agonist application to promote female health. As a safe interaction, melatonin treatment can be effective in alleviating symptoms of PMS. However, symptoms such as sleep disturbance, depressive mood, cognitive impairment are not specific and can be easily misdiagnosed. Connections between melatonin receptor, ovarian steroid dysfunction, and PMS are not consistent among past studies. Before final conclusions are drawn, more well-organized and rigorous studies are recommended.

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“…The utilization of zebrafish as a model to screen for compounds with a neuroprotective effect against cognitive impairment started a decade ago [ 53 ]. In recent years, zebrafish have become one of the popular animal models for screening the effects of neuroprotective drugs against various cognitive impairment models [ 47 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. ( Supplementary Table S1 ) This is attributed to the development of robust behavioral tests and well-characterized neurobehaviors and signaling pathways in zebrafish.…”

Section: Zebrafish Models For Pharmacological Studies On Learning And...mentioning

confidence: 99%

Zebrafish: A Pharmacological Model for Learning and Memory Research

et al. 2022

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Learning and memory are essential to organism survival and are conserved across various species, especially vertebrates. Cognitive studies involving learning and memory require using appropriate model organisms to translate relevant findings to humans. Zebrafish are becoming increasingly popular as one of the animal models for neurodegenerative diseases due to their low maintenance cost, prolific nature and amenability to genetic manipulation. More importantly, zebrafish exhibit a repertoire of neurobehaviors comparable to humans. In this review, we discuss the forms of learning and memory abilities in zebrafish and the tests used to evaluate the neurobehaviors in this species. In addition, the pharmacological studies that used zebrafish as models to screen for the effects of neuroprotective and neurotoxic compounds on cognitive performance will be summarized here. Lastly, we discuss the challenges and perspectives in establishing zebrafish as a robust model for cognitive research involving learning and memory. Zebrafish are becoming an indispensable model in learning and memory research for screening neuroprotective agents against cognitive impairment.

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Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish

Cited by 12 publications

References 66 publications

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment

Melatonin for premenstrual syndrome: A potential remedy but not ready

Zebrafish: A Pharmacological Model for Learning and Memory Research

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