Meliaceous Limonoids: Chemistry and Biological Activities

Tan, Qin‐Gang; Luo, Xiao‐Dong

doi:10.1021/cr9004023

Cited by 414 publications

(436 citation statements)

References 856 publications

Supporting

Mentioning

426

Contrasting

Unclassified

Order By: Relevance

“…Limonoids, as the major secondary metabolites of the Meliaceae family, are well-known for their abundance, structural diversity and a wide range of antifeedant, antimalarial, antimicrobial, cytotoxic, and growth-regulating activities [1,2]. The genus Trichilia of the Meliaceae consists of approximately 86 species, mainly distributed in the regions of tropical America, tropical Africa, India, Indochina, and the Malay Peninsula.…”

Section: Introductionmentioning

confidence: 99%

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

et al. 2016

View full text Add to dashboard Cite

Abstract:Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1-6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.

show abstract

Section: Introductionmentioning

confidence: 99%

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1 Azadirachta indica A. Juss., as one of the most popular pesticidal plant and traditional Indian medicine, was distributed throughout Asia, Africa, and other tropical parts of the world.…”

Section: Introductionmentioning

confidence: 99%

“…Juss., as one of the most popular pesticidal plant and traditional Indian medicine, was distributed throughout Asia, Africa, and other tropical parts of the world. [2][3][4] During the past four decades, more than 200 compounds, including terpenoids, 1 flavones, 5 steroids, 6 coumarins 7 and polysaccharides 8 had been isolated from different parts of A. indica, and some of them showed the significant bioactivities such as insecticides, 1,9,10 antifungal, 1,3 antitumor 1,2,11,12 and antimalarial. 1,13,14 Azadirachtin, as a well known natural pesticide, 3,15 was always extracted from the kernels of A. indica.…”

Section: Introductionmentioning

confidence: 99%

“…With the aim of searching for natural compounds with biological activities, we have investigated the kernels (after extracting azadirachtin) of A. indica collected from Mangshi Bright Neem Industry Developments Ltd., Yunnan Province of China. As a result, four new triterpenoids (1)(2)(3)(4), along with three known constituents (5-7), were isolated from the dried kernels of A. indica.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

New triterpenoids from the kernels of Azadirachta indica

Wang

Liu

Chen

et al. 2013

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Abstract:Three new limonoids (1-3) and a new intact triterpenoid (4), along with three known constituents (5-7), were isolated from the dried kernels (after extracting azadirachtin) of Azadirachta indica. The structures of the new compounds 1-benzoyl-3-deacetyl-1-detigloyl salannin (1), 7-tigloyl-12-oxo vilasini (2), azadiralactone (3) and azadirahemiacetal (4) were elucidated by means of spectroscopic analysis. The cytotoxities of these isolated constituents were assayed.

show abstract

“…Limonoides com atividade larvicida isolados de plantas. 88,[91][92][93][94][95][96][97][98] Os quassinoides, compostos altamente oxidados que possuem na sua maioria um esqueleto de vinte átomos de carbonos, são também originados de triterpenoides dos tipos eufol e tirucalol e encontrados na família Simaroubaceae. 92 A literatura relata um único trabalho sobre atividade larvicida contra A. aegypti de dois quassinoides (74 e 75) obtidos de Picrolemma sprucei, uma planta medicinal amazônica (Figura 18).…”

Section: Figura 16 Triterpenos Tetracíclicos Tirucalol (I) E Eufol (unclassified

Naturally Occurring Plant Compounds with Larvicidal Activity AgainstAedes aegypti

Garcez¹,

Garcez²,

Silva³

et al. 2013

Revista Virtual De Química

View full text Add to dashboard Cite

Abstract:The mosquito Aedes aegypti is a vector that carries the arboviroses responsible for dengue and dengue hemorrhagic fevers, diseases which are considered as major worldwide public health problems. The most widely adopted strategy for decreasing the incidence of these diseases resides in controlling the mosquito larvae population. The increasingly incidence of resistant mosquito populations due to the continuous use of synthetic insecticides, in addition to the public concern over environmental pollution and toxicity of the current commercial pesticides to nontarget organisms, have stimulated the search for alternative methods for mosquito control. In this regard, plant-derived compounds have emerged as a promising efficient and environmentally safe tool for reducing the larval population of Aedes aegypti mosquitoes. This review provides a survey on naturally occurring plant compounds belonging to different classes of secondary metabolites which have been shown to be active against Aedes aegypti.Keywords: Dengue; larvicidal compounds; bioactive natural products; Aedes aegypti. ResumoO mosquito Aedes aegypti é o vetor que transmite as arboviroses responsáveis pela dengue e a dengue hemorrágica, doenças consideradas um importante problema de saúde pública mundial. A estratégia mais amplamente adotada para diminuir a incidência dessas doenças consiste em controlar a população de larvas do mosquito. A ocorrência cada vez maior de populações resistentes de mosquitos, devido ao uso contínuo de inseticidas sintéticos, além da poluição ambiental e toxicidade dos pesticidas comerciais atualmente em uso a organismos não-alvo, tem estimulado a procura por métodos alternativos para o controle do mosquito. Neste sentido, compostos de origem vegetal surgem como uma estratégia promissora, eficiente e ambientalmente segura para reduzir a população de larvas de mosquitos Aedes aegypti. Esta revisão trata de pesquisas sobre compostos naturais originados de plantas pertencentes a diferentes classes de metabólitos secundários, que mostraram atividade contra larvas de Aedes aegypti.Palavras-chave: Dengue; substâncias larvicidas; produtos naturais bioativos; Aedes aegypti.

show abstract

Meliaceous Limonoids: Chemistry and Biological Activities

Cited by 414 publications

References 856 publications

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

New triterpenoids from the kernels of Azadirachta indica

Naturally Occurring Plant Compounds with Larvicidal Activity AgainstAedes aegypti

Contact Info

Product

Resources

About