Melioidosis in a Returned Traveller

Chagla, Zain; Aleksova, Natasha; Quirt, Jaclyn; Emery, J. G.; Kraeker, Christian; Haider, Shariq

doi:10.1155/2014/158323

Cited by 11 publications

(10 citation statements)

References 10 publications

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“…The number of case reports of melioidosis from various countries is continually increasing in the literature, as awareness of the disease is improving worldwide. Several recent cases of travel-associated melioidosis have also been documented in individuals returning to regions where the disease is nonendemic from Southeast Asia, Africa, and the Caribbean ( 4 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Development of Rapid Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Burkholderia pseudomallei

et al. 2016

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Burkholderia pseudomallei, the causative agent of melioidosis, is an environmental bacillus found in northeast Thailand. The mortality rate of melioidosis is ∼40%. An indirect hemagglutination assay (IHA) is used as a reference serodiagnostic test; however, it has low specificity in areas where the background seropositivity of healthy people is high. To improve assay specificity and reduce the time for diagnosis, four rapid enzyme-linked immunosorbent assays (ELISAs) were developed using two purified polysaccharide antigens (O-polysaccharide [OPS] and 6-deoxyheptan capsular polysaccharide [CPS]) and two crude antigens (whole-cell [WC] antigen and culture filtrate [CF] antigen) of B. pseudomallei. The ELISAs were evaluated using serum samples from 141 culture-confirmed melioidosis patients from Thailand along with 188 healthy donors from Thailand and 90 healthy donors from the United States as controls. The areas under receiver operator characteristic curves (AUROCC) using Thai controls were high for the OPS-ELISA (0.91), CF-ELISA (0.91), and WC-ELISA (0.90), while those of CPS-ELISA (0.84) and IHA (0.72) were lower. AUROCC values using U.S. controls were comparable to those of the Thai controls for all ELISAs except IHA (0.93). Using a cutoff optical density (OD) of 0.87, the OPS-ELISA had a sensitivity of 71.6% and a specificity of 95.7% for Thai controls; for U.S. controls, specificity was 96.7%. An additional 120 serum samples from tuberculosis, scrub typhus, or leptospirosis patients were evaluated in all ELISAs and resulted in comparable or higher specificities than using Thai healthy donors. Our findings suggest that antigen-specific ELISAs, particularly the OPS-ELISA, may be useful for serodiagnosis of melioidosis in areas where it is endemic and nonendemic.

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Section: Introductionmentioning

confidence: 99%

Development of Rapid Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Burkholderia pseudomallei

et al. 2016

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“…In addition, ProMED may be useful as a source of information for travel medicine practice. 10 Melioidosis is well described amongst both short- and long-term visitors to endemic areas and so needs to be considered in the evaluation and treatment of patients with sepsis or other febrile illnesses returning from endemic countries, 34,35 particularly from Southeast Asia and Northern Australia as has been seen in this study. Melioidosis should be considered in anyone with compatible clinical manifestations, even in the absence of apparent risk of exposure to B. pseudomallei .…”

Section: Discussionmentioning

confidence: 79%

Human melioidosis reported by ProMED

Nasner-Posso

Cruz-Calderón

Montúfar-Andrade

et al. 2015

International Journal of Infectious Diseases

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HighlightsProMED would be used to assess the reliability of the data of emerging infectious diseases, such as melioidosis.The study evaluated the effectiveness of ProMED as a source of epidemiological data by focusing on melioidosis.This work identified 4630 cases of melioidosis with an overall case fatality rate of 11%, mainly reported from Australia, Thailand, Singapore, Vietnam, and Malaysia.Although certain areas need to be improved, ProMED provided good information about melioidosis.

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“…The clinical manifestations of melioidosis vary from benign localized abscesses to severe pneumonia, to acute fulminating septicemia with multiple abscesses, often leading to death [ 1 , 2 ]. Pericardial effusion is a rare presentation of melioidosis and has previously been reported in a series of case reports [ 3 , 4 ]. Constrictive pericarditis is an uncommon post-inflammatory disorder characterized by a variably thickened, fibrotic, and frequently calcified, pericardium.…”

Section: Discussionmentioning

confidence: 99%

“…Melioidosis is a tropical infection that most commonly occurs in South East Asia, India and northern Australia [ 2 ]. Because of the availability of long-distance travel, sporadic cases of melioidosis have been reported, including a case in a Swiss traveler returning home after visiting Thailand, which is an endemic area for Burkholderia pseudomallei [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Constrictive Pericarditis Associated with Melioidosis in an Immunocompetent Patient Treated by Pericardiectomy

Ramsamy

Lee

et al. 2018

Am J Case Rep

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Patient: Male, 38Final Diagnosis: Constrictive pericarditisSymptoms: Shortness of breathMedication: —Clinical Procedure: Pericardiocentesis • pericardiectomySpecialty: CardiologyObjective:Unusual clinical courseBackground:Melioidosis is a rare tropical bacterial infection caused by the Gram-negative soil saprophyte, Burkholderia pseudomallei. Melioidosis can mimic a variety of diseases due to its varied presentation, and unless it is treated rapidly, it can be fatal. A rare case of melioidosis, with pericarditis and pericardial effusion, is described, which demonstrates the value of early diagnosis with echocardiography and pericardiocentesis.Case Report:A 38-year-old native (Iban) East Malaysian man presented with shortness of breath and tachycardia. Transthoracic echocardiography (TTE) showed cardiac tamponade. Urgent pericardiocentesis drained a large amount of purulent pericardial fluid that grew Burkholderia pseudomallei. Despite appropriate dose and duration of intravenous treatment with ceftazidime followed by meropenem, the patient developed recurrent pericardial effusion and right heart failure due to constrictive pericarditis. The diagnosis of constrictive pericarditis was confirmed by computed tomography (CT) and surgical exploration. Following pericardiectomy, his symptoms resolved, but patient follow-up was recommended for possible sequelae of constrictive pericarditis.Conclusions:After the onset of melioidosis pericarditis, the authors recommend follow-up and surveillance for possible complication of constrictive pericarditis.

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Melioidosis in a Returned Traveller

Cited by 11 publications

References 10 publications

Development of Rapid Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Burkholderia pseudomallei

Development of Rapid Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Burkholderia pseudomallei

Human melioidosis reported by ProMED

A Case of Constrictive Pericarditis Associated with Melioidosis in an Immunocompetent Patient Treated by Pericardiectomy

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