Melioidosis in a Tropical City State, Singapore

Lo, Tong Jen; Ang, Li Wei; James, Lyn; Goh, Kee Tai

doi:10.3201/eid1510.090246

Cited by 53 publications

(63 citation statements)

References 7 publications

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“…The routes of infection include percutaneous inoculation, inhalation or ingestion of contaminated food or water. Additionally, seasonal monsoonal rainfall has been associated with pneumonia and more severe disease [7,14,15].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the early host immune response to two widely diverse virulent strains of Burkholderia pseudomallei that cause acute or chronic infections in BALB/c mice

Amemiya

Dankmeyer

Fetterer

et al. 2015

Microbial Pathogenesis

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Section: Introductionmentioning

confidence: 99%

Comparison of the early host immune response to two widely diverse virulent strains of Burkholderia pseudomallei that cause acute or chronic infections in BALB/c mice

Amemiya

Dankmeyer

Fetterer

et al. 2015

Microbial Pathogenesis

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“…Majority of cases with melioidosis were also diagnosed in farmers in studies from Thailand and Malaysia 5,24 . Melioidosis has been also been reported in construction workers in a study from Singapore 25 and one of our patients was a returned construction worker from Singapore. One patient in our study who was unemployed had a history of drug abuse and fishing hobby.…”

Section: Discussionmentioning

confidence: 89%

“…The maleto-female ratio for melioidosis was also higher in all studies performed in Malaysia, Australia, and Singapore. [23][24][25] Almost one-third of our patients were farmers. Majority of cases with melioidosis were also diagnosed in farmers in studies from Thailand and Malaysia 5,24 .…”

Section: Discussionmentioning

confidence: 99%

Socio-demographic, Clinical and Laboratory Characteristics of Melioidosis: Four-Year Experience of Managing Consecutive 11 Cases in a Tertiary Care Hospital of Bangladesh

et al. 2017

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“…Recently, epidemiological studies support inhalation as the mode of transmission of B. pseudomallei after heavy monsoonal rains and winds [5], [6], [10], [12]–[13], [17], [21]–[22]. Animal studies also show that exhaled B. pseudomallei aerosols lead to a lower lethal dose, 50% (LD 50 ) and a shorter incubation time compared to intraperitoneal and subcutaneous injection [23]–.…”

Section: Introductionmentioning

confidence: 99%

The Concentrations of Ambient Burkholderia Pseudomallei during Typhoon Season in Endemic Area of Melioidosis in Taiwan

et al. 2014

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BackgroundMelioidosis is a severe bacterial infection caused by Burkholderia pseudomallei with a high case-fatality rate. Epidemiological and animal studies show the possibility of inhalation transmission. However, no B. pseudomallei concentrations in ambient air have been researched. Here, we developed a method to quantify ambient B. pseudomallei and then measured concentrations of ambient B. pseudomallei during the typhoon season and the non-typhoon season to determine the factors influencing ambient B. pseudomallei levels.MethodsWe quantified ambient B. pseudomallei by using a filter/real-time qPCR method in the Zoynan Region in Kaohsiung, southern Taiwan. Twenty-four hour samples were collected at a sampling rate of 20 L/min every day from June 11 to December 21, 2012 including during the typhoon season (June to September) and reference season (October to December).ResultsWe successfully developed a filtration/real-time qPCR method to quantify ambient B. pseudomallei. To our knowledge, this is the first report describing concentrations of ambient B. pseudomallei. Ambient B. pseudomallei were only detected during the typhoon season when compared to the reference season. For the typhoons affecting the Zoynan Region, the positive rates of ambient B. pseudomallei were very high at 80% to 100%. During June to December, rainfall was positively correlated with ambient B. pseudomallei with a statistical significance. Sediment at a nearby pond significantly influenced the concentration of ambient B. pseudomallei. During the typhoon month, the typhoon was positively correlated with ambient B. pseudomallei whereas wind speed was reversely correlated with ambient B. pseudomallei.ConclusionsOur data suggest the possibility of transmission of B. pseudomallei via inhalation during the typhoon season.

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Melioidosis in a Tropical City State, Singapore

Cited by 53 publications

References 7 publications

Comparison of the early host immune response to two widely diverse virulent strains of Burkholderia pseudomallei that cause acute or chronic infections in BALB/c mice

Comparison of the early host immune response to two widely diverse virulent strains of Burkholderia pseudomallei that cause acute or chronic infections in BALB/c mice

Socio-demographic, Clinical and Laboratory Characteristics of Melioidosis: Four-Year Experience of Managing Consecutive 11 Cases in a Tertiary Care Hospital of Bangladesh

The Concentrations of Ambient Burkholderia Pseudomallei during Typhoon Season in Endemic Area of Melioidosis in Taiwan

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