Melioidosis in Goats

Olds, R. J.; Lewis, F. A.

doi:10.1111/j.1751-0813.1954.tb05416.x

Cited by 28 publications

(16 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports of both natural and experimental melioidosis in goats have had variable findings in regards to liver lesions, with some reporting no lesions [27], [44] and others finding hepatic lesions to be quite common [18], [20], [22], [28]. This finding may be a result of strain variation, individual host/population factors, or the duration of infection.…”

Section: Discussionmentioning

confidence: 99%

Development and Characterization of a Caprine Aerosol Infection Model of Melioidosis

et al. 2012

View full text Add to dashboard Cite

Infection with Burkholderia pseudomallei causes the disease melioidosis, which often presents as a serious suppurative infection that is typically fatal without intensive treatment and is a significant emerging infectious disease in Southeast Asia. Despite intensive research there is still much that remains unknown about melioidosis pathogenesis. New animal models of melioidosis are needed to examine novel aspects of pathogenesis as well as for the evaluation of novel therapeutics. The objective of the work presented here was to develop a subacute to chronic caprine model of melioidosis and to characterize the progression of disease with respect to clinical presentation, hematology, clinical microbiology, thoracic radiography, and gross and microscopic pathology. Disease was produced in all animals following an intratracheal aerosol of 104 CFU delivered, with variable clinical manifestations indicative of subacute and chronic disease. Bronchointerstitial pneumonia was apparent microscopically by day 2 and radiographically and grossly apparent by day 7 post infection (PI). Early lesions of bronchopneumonia soon progressed to more severe bronchointerstitial pneumonia with pyogranuloma formation. Extrapulmonary dissemination appeared to be a function of pyogranuloma invasion of pulmonary vasculature, which peaked around day 7 PI. Histopathology indicated that leukocytoclastic vasculitis was the central step in dissemination of B. pseudomallei from the lungs as well as in the establishment of new lesions. While higher doses of organism in goats can produce acute fatal disease, the dose investigated and resulting disease had many similarities to human melioidosis and may warrant further development to provide a model for the study of both natural and bioterrorism associated disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Development and Characterization of a Caprine Aerosol Infection Model of Melioidosis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Goats appear to be able to mount an efficacious adaptive immune response to B. pseudomallei , as evidenced by the presence of sterile lesions in both natural and experimental disease (Olds & Lewis ; Laws & Hall ; Thomas et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…A higher incidence of inguinal lymph node involvement would be expected because many rice farmers are believed to be infected percutaneously through cuts on their feet. Natural disease in goats has also been shown to involve lymph nodes, but the most commonly affected are the MedLNs draining the lungs (Olds & Lewis ; Laws & Hall ; Choy et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…The goat, as a naturally affected species, has a base of scientific literature describing the clinical presentation and pathology of melioidosis (Lewis & Olds ; Olds & Lewis ; Sutmoller et al . ; Omar ; Narita et al .…”

mentioning

confidence: 99%

“…The goat, as a naturally affected species, has a base of scientific literature describing the clinical presentation and pathology of melioidosis (Lewis & Olds 1952;Olds & Lewis 1954;Sutmoller et al 1957;Omar 1963;Narita et al 1982; Thomas et al 1988; Van der Lugt & Henton 1995;Soffler et al 2012), which compares well with human disease in terms of clinical presentation, epizootiology (Limmathurotsakul et al 2012), organ distribution and histopathology (Piggott & Hochholzer 1970;Wong et al 1995). While goats more frequently develop chronic disease, acute presentations are possible and therefore, goat models are likely amenable to the incorporation of risk factors to increase susceptibility or acute disease.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunological responses in chronic melioidosis

Soffler

Bosco‐Lauth

Aboellail

et al. 2014

Int J Experimental Path

View full text Add to dashboard Cite

Melioidosis is a severe suppurative to granulomatous infection caused by Burkholderia pseudomallei. The disease is endemic to South-East Asia and Northern Australasia and is also of interest as a potential biological weapon. Natural infection can occur by percutaneous inoculation, inhalation or ingestion, but the relative importance of each route is unknown. Experimental infection models using mice have shown inhalation to be the most lethal route of exposure, but few studies have examined the pathogenesis of percutaneous infection despite its presumptive importance in natural disease. Caprine models are useful in the study of melioidosis because goats are susceptible to natural infection by B. pseudomallei, display similar epizootiology/epidemiology to that of humans within the endemic range and develop similar pathologic lesions. Percutaneous inoculation with 10(4) CFU of B. pseudomallei produced disease in all experimental animals with rapid dissemination to the lungs, spleen and kidneys. Initial fever was brief, but temperatures did not return to pre-infection levels until day 18, concurrent with a dramatic lymphocytosis and the transition to chronic disease. Distribution and appearance of gross pathologic and radiographic lesions in goats were similar to caprine aerosol infection and to reported human disease. The similarities seen despite different routes of infection suggest that host or bacterial factors may be more important than the route of infection in disease pathogenesis. The nature of melioidosis in goats makes it amenable for modelling additional risk factors to produce acute clinical disease, which is important to the study of human melioidosis.

show abstract

Mammary Gland and Milk Production

Smith

Sherman

2009

Goat Medicine

View full text Add to dashboard Cite

Melioidosis in Goats

Cited by 28 publications

References 2 publications

Development and Characterization of a Caprine Aerosol Infection Model of Melioidosis

Development and Characterization of a Caprine Aerosol Infection Model of Melioidosis

Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunological responses in chronic melioidosis

Mammary Gland and Milk Production

Contact Info

Product

Resources

About