Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985–2018

Rozemeijer, Wouter; Rijkeboer, A. A.; Birnie, Emma; Cremers, Anne Lia; Grobusch, Martin P.; Kolkman, Saskia; Roelofs, Joris J. T. H.; Savelkoel, Jelmer; Wiersinga, W. Joost; Scholing, Maarten; Dijk, Karin van; Mascini, Ellen M.; Veen, H. van der; Bijllaardt, Wouter van den; Notermans, Daan W.; Reubsaet, Frans A.G.; Vries, Maaike de; Smeets, Leonard C.; Ott, Alewijn; Krimpen, Kees van; Soetekouw, Robin; Herpers, Bjorn L.; Watttel-Louis, G. Hanke; Waar, Karola; Schwandt, Noortje L.Q.; Maat, Ianthe; Dofferhoff, A.S.M.; Vermeulen, Joost N.; Westreenen, Mireille van; Man, Peter de; Hofland, Regina W.; Gorp, Joost van; Thijsen, Steven; Velden, Lieven B. van der; Verduin, Cornelis M.

doi:10.1016/j.tmaid.2019.07.017

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…In addition, although cases of melioidosis imported into non-endemic countries across Europe are being reported with increasing frequency, the overall numbers remain low and the availability of better diagnostic resources and treatment options mean that the high mortality rates seen in resource-limited countries are not observed. 44,47,48 Altogether, the previous injection of biodefence-driven funding for melioidosis research has undoubtedly moved the field forward, particularly in high-income countries, but in reality this has had limited impact on incidence and mortality in most melioidosis-endemic regions. 49…”

Section: Global Funding For Melioidosismentioning

confidence: 99%

A call to action: time to recognise melioidosis as a neglected tropical disease

Savelkoel

Dance

Currie

et al. 2022

The Lancet Infectious Diseases

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Section: Global Funding For Melioidosismentioning

confidence: 99%

A call to action: time to recognise melioidosis as a neglected tropical disease

Savelkoel

Dance

Currie

et al. 2022

The Lancet Infectious Diseases

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“…These developments could make individuals more vulnerable to emerging infectious diseases, such as melioidosis. Given the rise in the numbers of immunocompromised travelers, the incidence of imported melioidosis might also increase [23]. Most importantly, however, current epidemiological transitions in low-income and middle-income countries (LMICs) may lead to increased rates of individuals with risk factors for melioidosis.…”

Section: Epidemiological Transitionmentioning

confidence: 99%

Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change

Birnie

Biemond

Wiersinga

2022

Current Opinion in Infectious Diseases

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Purpose of reviewMelioidosis, caused by the soil-dwelling bacterium Burkholderia pseudomallei, is a tropical infection associated with high morbidity and mortality. This review summarizes current insights into melioidosis' endemicity, focusing on epidemiological transitions, zoonosis, and climate change. Recent findingsEstimates of the global burden of melioidosis affirm the significance of hot-spots in Australia and Thailand. However, it also highlights the paucity of systematic data from South Asia, The Americas, and Africa. Globally, the growing incidence of diabetes, chronic renal and (alcoholic) liver diseases further increase the susceptibility of individuals to B. pseudomallei infection. Recent outbreaks in nonendemic regions have further exposed the hazard from the trade of animals and products as potential reservoirs for B. pseudomallei. Lastly, global warming will increase precipitation, severe weather events, soil salinity and anthrosol, all associated with the occurrence of B. pseudomallei. SummaryEpidemiological transitions, zoonotic hazards, and climate change are all contributing to the emergence of novel melioidosis-endemic areas. The adoption of the One Health approach involving multidisciplinary collaboration is important in unraveling the real incidence of B. pseudomallei, as well as reducing the spread and associated mortality. KeywordsBurkholderia pseudomallei, climate change, epidemiological transition, melioidosis, one health, zoonosis && ]. Human health has developed in unprecedented ways. As a consequence, individuals become older and suffer more frequently from comorbidities. Together with advances in mobility and globalization

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“…Global travel has increased substantially with 1.3 billion trips made in 2017, of which 323 million went to Asia and the Pacific regions. 26 Furthermore, age of travelers continues to increase, as does clinically significant coexisting comorbidities such as diabetes or chronic liver/kidney disease. 26 Review of articles from PubMed and Web of Science databases found that imported cases of melioidosis into Europe are largely from Thailand (53%), in travelers on holiday who were hospitalized within 1 month following return to Europe.…”

Section: Returned Travelersmentioning

confidence: 99%

“…26 Furthermore, age of travelers continues to increase, as does clinically significant coexisting comorbidities such as diabetes or chronic liver/kidney disease. 26 Review of articles from PubMed and Web of Science databases found that imported cases of melioidosis into Europe are largely from Thailand (53%), in travelers on holiday who were hospitalized within 1 month following return to Europe. 27 Regardless of the multifaceted nature of presentations, pneumonia remained the most common diagnosis, although misdiagnoses were common at 21%.…”

Section: Returned Travelersmentioning

confidence: 99%

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

Virk

Mukhopadhyay

Wiersinga

2020

Semin Respir Crit Care Med

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AbstractMelioidosis, caused by the facultative intracellular gram-negative pathogen Burkholderia pseudomallei, is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of B. pseudomallei in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Innovative environmental studies are also uncovering how hydrodynamic, pedology, fauna, and weather events influence geographic distribution and incidence of melioidosis cases. Of concern is the changes associated with global warming, which will be conducive to B. pseudomallei in combination with the global diabetes pandemic. In fact, over 80% of patient developing melioidosis have underlying comorbidities. For this great mimicker, culture remains the mainstay of diagnosis and despite availability of other assays, challenges still remain in reducing time to diagnosis and avoiding misdiagnosis. With institution of timely antimicrobials such as ceftazidime and supportive intensive care, overall mortality can be reduced to 10%, although this can still be as high as 50% in poorly resourced areas. Promise is on the horizon with the first human vaccine trials being planned for 2021. Meanwhile new multiomics techniques are giving us a better understanding of the role of virulence and host–pathogen interactions on patient outcomes.

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Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985–2018

Cited by 18 publications

References 32 publications

A call to action: time to recognise melioidosis as a neglected tropical disease

A call to action: time to recognise melioidosis as a neglected tropical disease

Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

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