Melioidosis Manifesting as Chronic Femoral Osteomyelitis in Patient from Ghana

Mabayoje, Diana Ayoola; Kenna, D.; Dance, David A. B.; NicFhogartaigh, Caoimhe

doi:10.3201/eid2801.211800

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…7,9,12,13 Other presentations such as abscess formation (prostate, spleen, liver, and kidney), genitourinary, skin and soft tissue, osteomyelitis and septic arthritis, neurological involvement, suppurative parotitis, mycotic aneurysm, and ocular involvement, are also reported. [6][7][8]10,[14][15][16] Melioidosis only involving the spleen is relatively uncommon, as described in this report. 17,18 The diagnosis of melioidosis remains challenging, particularly in non-endemic areas with laboratories having no experience with B. pseudomallei.…”

Section: Discussionmentioning

confidence: 56%

Chronic Splenic Melioidosis in a Patient with Fever of Unknown Origin Diagnosed by Metagenomics Next-Generation Sequencing: An Emerging Cause and Literature Review

Sheng¹,

Li²,

Chen³

et al. 2023

IDR

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Introduction Human melioidosis is an emerging infectious disease in tropical areas of China, and chronic melioidosis can be a rare cause of fever of unknown origin (FUO). Timely diagnosis may improve the prognosis of melioidosis. Case Presentation We report a case of melioidosis with splenic abscesses caused by Burkholderia pseudomallei in a 57-year-old man, who presented with FUO. Positron emission tomography/computed tomography (PET/CT) revealed multiple hypermetabolic lesions in the spleen. The spleen biopsy was conducted and metagenomics next-generation sequencing (mNGS) of the spleen specimen identified the presence of B. pseudomallei , confirming the diagnosis of melioidosis. Antimicrobial treatment was initiated with intravenous meropenem, followed by oral faropenem. During the follow-up, the patient was in good condition except having a low-grade fever occasionally. A splenectomy was performed, and subsequent culture and mNGS of the spleen pus were both positive for B. pseudomallei . Histopathological characteristics of chronic splenic melioidosis were noted. Conclusion Melioidosis is a serious endemic disease, and it is critical to raise awareness about this disease.

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Section: Discussionmentioning

confidence: 56%

Chronic Splenic Melioidosis in a Patient with Fever of Unknown Origin Diagnosed by Metagenomics Next-Generation Sequencing: An Emerging Cause and Literature Review

Sheng¹,

Li²,

Chen³

et al. 2023

IDR

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“…A review of the meeting documented the countries with confirmed melioidosis cases and the plans for supporting improved case finding through initiatives, including the African Sepsis Alliance [12 ▪ ]. The most recent example of unmasking of melioidosis in Africa is from Ghana, where, in addition to a reported case of chronic melioidosis osteomyelitis [13], B. pseudomallei has been recovered from a formal soil sampling study of a rice farm in south-central Ghana [14]. Preliminary environmental sampling from Cameroon, however, recovered no B. pseudomallei [15].…”

Section: Epidemiologymentioning

confidence: 99%

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

Currie

2022

Current Opinion in Infectious Diseases

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Purpose of reviewMelioidosis and its causative bacterium Burkholderia pseudomallei are being found in unexpected locations and bacterial genotyping is providing new insights into global spread and where and how individuals are being infected. This review summarizes recent studies covering the epidemiology, diagnosis, treatment, and prevention of melioidosis. Recent findingsWhole-genome sequencing of B. pseudomallei from patients and environmental sampling is informing the phylogeography of B. pseudomallei at regional, continental, and global levels, while also defining the epidemiology for individual cases. The situation in Africa remains the most unresolved, while the evolving story of B. pseudomallei in the Americas may establish that B. pseudomallei is endemic in parts of southern USA. Guidelines for diagnosis and treatment of melioidosis are well established, and published mortality has decreased from 50% or higher to 10% or lower in some countries but access to laboratory and therapeutic resources are not available or are extremely limited in many melioidosis-endemic regions.

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“…B. pseudomallei is considered endemic in Africa with estimates suggesting the presence of large numbers of underreported infection across the continent [ 7 , 8 ]. Most reported cases are in travelers returning from the African continent, as exemplified by a recent case of melioidosis presenting as chronic femoral osteomyelitis in a Ghanaian man living in the United Kingdom [ 3 , 4 , 22 ▪ ]. A comprehensive Dutch retrospective surveillance study of 33 travelers with B. pseudomallei infection showed that imported melioidosis could additionally serve as sentinels for detecting the disease in areas not yet considered melioidosis-endemic, such as The Gambia [ 23 ].…”

Section: Current Insights Into the Epidemiology Of Melioidosismentioning

confidence: 99%

Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change

Birnie

Biemond

Wiersinga

2022

Current Opinion in Infectious Diseases

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Purpose of reviewMelioidosis, caused by the soil-dwelling bacterium Burkholderia pseudomallei, is a tropical infection associated with high morbidity and mortality. This review summarizes current insights into melioidosis' endemicity, focusing on epidemiological transitions, zoonosis, and climate change. Recent findingsEstimates of the global burden of melioidosis affirm the significance of hot-spots in Australia and Thailand. However, it also highlights the paucity of systematic data from South Asia, The Americas, and Africa. Globally, the growing incidence of diabetes, chronic renal and (alcoholic) liver diseases further increase the susceptibility of individuals to B. pseudomallei infection. Recent outbreaks in nonendemic regions have further exposed the hazard from the trade of animals and products as potential reservoirs for B. pseudomallei. Lastly, global warming will increase precipitation, severe weather events, soil salinity and anthrosol, all associated with the occurrence of B. pseudomallei. SummaryEpidemiological transitions, zoonotic hazards, and climate change are all contributing to the emergence of novel melioidosis-endemic areas. The adoption of the One Health approach involving multidisciplinary collaboration is important in unraveling the real incidence of B. pseudomallei, as well as reducing the spread and associated mortality. KeywordsBurkholderia pseudomallei, climate change, epidemiological transition, melioidosis, one health, zoonosis && ]. Human health has developed in unprecedented ways. As a consequence, individuals become older and suffer more frequently from comorbidities. Together with advances in mobility and globalization

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Melioidosis Manifesting as Chronic Femoral Osteomyelitis in Patient from Ghana

Cited by 9 publications

References 14 publications

Chronic Splenic Melioidosis in a Patient with Fever of Unknown Origin Diagnosed by Metagenomics Next-Generation Sequencing: An Emerging Cause and Literature Review

Chronic Splenic Melioidosis in a Patient with Fever of Unknown Origin Diagnosed by Metagenomics Next-Generation Sequencing: An Emerging Cause and Literature Review

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change

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