Melkersson-Rosenthal syndrome

Carolino, Fabrícia; Fernandes, Margarida Sá; Plácido, José Luís

doi:10.1016/j.pbj.2015.10.001

Cited by 5 publications

(5 citation statements)

References 28 publications

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“… 9 Our cases were differentiated from Melkersson-Rosenthal syndrome on the basis of absence of lingua plicata and orofacial edema. 10 In congenital facial muscular atrophy, positive family history and prenatal or postnatal trauma are generally present, which were not reported in our cases. Muscular dystrophy, cerebral palsy and congenital myopathies are primarily diseases of muscular origin whereas Mobius syndrome has muscular pathologies secondary to nerve involvement.…”

Section: Discussionmentioning

confidence: 48%

Rare features associated with Mobius syndrome: Report of two cases

Ghosh¹,

Shetty²,

Hegde³

et al. 2017

J Dent Res Dent Clin Dent Prospects

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Mobius syndrome is a rare congenital disorder with the preliminary diagnostic criteria of congenital facial and abducent nerve palsy. Involvement of other cranial nerves, too, is common. Prevalence rate of this syndrome is approximately 1 in 100,000 neonates. It is of unknown etiology with sporadic occurrence. However, data regarding the occurrence rate in India is limited. Features such as orofacial malformations, limb defects, and musculoskeletal, behavioral, and cognitive abnormalities might be associated. A thorough evaluation to identify the condition and establishing an adequate treatment plan is of utmost important in this condition. We are reporting clinical and radiographic features of Mobius syndrome in two cases along with unusual findings of limb and neck deformity.

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Section: Discussionmentioning

confidence: 48%

Rare features associated with Mobius syndrome: Report of two cases

Ghosh¹,

Shetty²,

Hegde³

et al. 2017

J Dent Res Dent Clin Dent Prospects

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“…Its clinical diagnosis is usually via exclusion. The observation of familial inheritance and the suggestion of a relationship with autosomal translocation t(9;21) (p11; p11) supports the hypothesis of genetic predisposition [29,30]. The proposed potential etiologies are based on the immunogenicity (allergy and autoimmunity -not yet proved) of the syndrome, associated infections, and the genetics of the patient.…”

Section: Discussionmentioning

confidence: 53%

Melkersson-Rosenthal Syndrome: A Mysterious Path to Recurrent Facial Palsy

Gomes¹

2022

J Clin Image & Rep

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Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous syndrome of unknown etiology with chronic and progressive course, and clinical diagnosis is usually by exclusion. Rarely, it presents with the full triad of recurrent or persistent facial swelling, relapsing facial palsy, and a fissured, geographic tongue. It is rarely possible to observe all aspects of the classical triad at the same time, since these symptoms may appear in different times of life cycle. Although etiology of MRS is unclear, various factors such as infections, genetic predisposition, immune deficiency, food intolerance and stress have been held responsible. The differential diagnosis of MRS includes also chronic inflammatory and infective diseases characterized by granulomatous infiltration, as well as rosacea, contact dermatitis, allergic reactions and Bell’s palsy. The therapeutic options are varied, though most commonly include corticosteroid therapy and nerve decompression surgery

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“…Its clinical diagnosis is usually via exclusion. The observation of familial inheritance and the suggestion of a relationship with autosomal translocation t(9;21)(p11;p11) supports the hypothesis of genetic predisposition [4,7]. Histopathological examination, however, can help to exclude other conditions and allows us to further characterize the underlying inflammatory process, which can help to better understand the mechanisms of the disease [7].…”

mentioning

confidence: 74%

Melo¹,

Amorim²,

Nascimento³

et al. 2021

J Otolaryngol Rhinol

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The authors report the case of a 14-year-old girl with Melkersson-Rosenthal syndrome in its classical form, with the triad of recurrent peripheral facial paralysis, upper lip edema and fissured tongue. A rare disease of unknown etiology, it has a chronic and progressive course, and clinical diagnosis is usually by exclusion. An individualized, multidisciplinary approach is fundamental for the treatment of the symptoms and avoids complications and permanent sequelae. The therapeutic options are varied, though most commonly include corticosteroid therapy and nerve decompression surgery.

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Melkersson-Rosenthal syndrome – delay in the diagnosis of an early-onset oligosymptomatic variant

Cited by 5 publications

References 28 publications

Rare features associated with Mobius syndrome: Report of two cases

Rare features associated with Mobius syndrome: Report of two cases

Melkersson-Rosenthal Syndrome: A Mysterious Path to Recurrent Facial Palsy

Melkersson-Rosenthal Syndrome

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