Melkersson-Rosenthal Syndrome

Orlando, Michael R.; Atkins, James S.

doi:10.1001/archotol.1990.01870060086017

Cited by 32 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The orofacial swelling is usually sudden and, in most cases, precedes facial paralysis by weeks, months and even years 2 5 6. The first episode of oedema, sometimes accompanied by fever and mild constitutional symptoms (as seen in the present case, eg, headache, visual disturbance), usually subsides completely in hours or days.…”

Section: Discussionmentioning

confidence: 56%

Clinicopathological significance of Melkersson-Rosenthal syndrome

Bohra¹,

Kariya

Bargale

et al. 2015

BMJ Case Reports

View full text Add to dashboard Cite

Melkersson-Rosenthal syndrome (MRS) classically shows a triad of orofacial swelling, fissured tongue and facial palsy, more commonly the oligosymptomatic form. The orofacial swelling is characterised by swollen reddish-brown non-pruritic lips and facial oedema. In one-third to one half of patients, fissured tongue is seen, which also aids in diagnosis. The histological finding of MRS includes non-caseating, sarcoidal granulomas, but their absence does not exclude the diagnosis. All these findings together form a basis for a cautious search for confrontational reasons for the symptom complex of MRS.

show abstract

Section: Discussionmentioning

confidence: 56%

Clinicopathological significance of Melkersson-Rosenthal syndrome

Bohra¹,

Kariya

Bargale

et al. 2015

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…The most frequent finding of MRS is acute, diffuse, painless and non-pitting orofacial edema which is most frequently seen on lips (10,11,15,16). The upper lip is involved more frequently.…”

Section: Discussionmentioning

confidence: 99%

Melkersson-Rosenthal Syndrome: A Case Report

Başman

Gümüşok

Değerli

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

show abstract

“…Histopathologic examination of the tongue may aid the diagnosis. The suggestion that orofacial granulomatosis is a variant of sarcoidosis has not been confirmed, although occasional patients have a positive Kveim reaction or a raised serum concentration of angiotensin-converting enzyme (6,7). Nevertheless, only very few patients with MRS have manifestations of sarcoidosis or Crohn's disease.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous glossitis: a case report

Şentürk¹,

Aydın²,

Yıldız

et al. 2004

J Oral Sci

View full text Add to dashboard Cite

IntroductionThe term orofacial granulomatosis was introduced to encompass the broad spectrum of non-necrotizing granulomatous inflammation in the oral and facial region, including patients with the complete triad of MelkerssonRosenthal syndrome (MRS), chelitis granulomatosa, sarcoidosis, Crohn's disease and infectious disorders such as tuberculosis (1,2). There may be several underlying etiologic mechanisms, with similar clinical and pathologic presentations, often manifesting at different points in time (3).Granulomatous glossitis was first described as a peculiar manifestation of MRS by Schuermann in 1952 (4). The typical triad of MRS is rarely seen simultaneously, and involvement of the tongue as a sole manifestation of MRS is much rarer. In monosymptomatic cases, making a clear diagnosis is difficult, and therefore a complete differential diagnosis for the other recurrent or persistent disorders characterized by macroglossia has to be done (5).Herein we report a case of granulomatous glossitis with no associated systemic disorder that was unresponsive to clofazimine and metronidazole, yet showed minor improvement with tetracycline. Case ReportA 50-year-old man presented with a complaint of enlargement of the tongue associated with small glossal tags. The papules had developed at the edge of the tongue and gradually increased in number during the previous five years. The patient complained of speech impairment, hypersalivation and a burning sensation on eating. He denied swelling of the lips, buccal and labial mucosa, and the face. His medical history was unremarkable except for hypertension that had been controlled with anti-hypertensive drug therapy for the previous 10 years.Dermatologic examination revealed slight enlargement of the tongue with a deep central furrow, multiple shallow radial fissures and multiple white mucosal tags at the edge of the tongue (Figs. 1 and 2).Laboratory investigations including a complete blood count, erythrocyte sedimentation rate, serum electrolytes, hepatic and renal function tests, serum iron level, anti-HIV antibodies, angiotensin converting enzyme level, thyroid function tests, IgG, IgA, IgM, IgE levels, ANA, anti-DNA, 24 hours urine calcium level, and stool examination for the presence of blood were all either negative or within normal limits.

show abstract

Melkersson-Rosenthal Syndrome

Cited by 32 publications

References 21 publications

Clinicopathological significance of Melkersson-Rosenthal syndrome

Clinicopathological significance of Melkersson-Rosenthal syndrome

Melkersson-Rosenthal Syndrome: A Case Report

Granulomatous glossitis: a case report

Contact Info

Product

Resources

About