Melongosides n, o and p: steroidal saponins from seeds of solanum melongena

Кинтя, П. К.; Shvets, S. A.

doi:10.1016/s0031-9422(00)81067-5

Cited by 23 publications

(2 citation statements)

References 5 publications

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“…A British study used colorimetry to determine the average glycoalkaloid content of two eggplant samples of about 8 mg/100 g fresh weight . Kintia and Shvets isolated and characterized three steroidal saponins from seeds of Moldavian S. melongena.…”

Section: Chemistry and Prevalence Of Glycoalkaloids In Foodmentioning

confidence: 99%

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Friedman¹

2015

J. Agric. Food Chem.

173

106

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Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants, potatoes, and tomatoes. Exposure of cancer cells to glycoalkaloids produced by eggplants (α-solamargine and α-solasonine), potatoes (α-chaconine and α-solanine), and tomatoes (α-tomatine) or their hydrolysis products (mono-, di-, and trisaccharide derivatives and the aglycones solasodine, solanidine, and tomatidine) inhibits the growth of the cells in culture (in vitro) as well as tumor growth in vivo. This overview comprehensively surveys and consolidates worldwide efforts to define the following aspects of these natural compounds: (a) their prevalence in the three foods; (b) their chemistry and structure-activity relationships; (c) the reported factors (biomarkers, signaling pathways) associated with apoptosis of bone, breast, cervical, colon, gastric, glioblastoma, leukemia, liver, lung, lymphoma, melanoma, pancreas, prostate, and squamous cell carcinoma cell lines in vitro and the in vivo inhibition of tumor formation and growth in fish and mice and in human skin cancers; and (d) future research needs. The described results may make it possible to better relate the structures of the active compounds to their health-promoting function, individually, in combination, and in food, and allow the consumer to select glycoalkaloid-containing food with the optimal content of nontoxic beneficial compounds. The described findings are expected to be a valuable record and resource for further investigation of the health benefits of food-related natural compounds.

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Section: Chemistry and Prevalence Of Glycoalkaloids In Foodmentioning

confidence: 99%

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Friedman¹

2015

J. Agric. Food Chem.

173

106

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“…[8] Two steroidal saponins -melongoside L and melongoside M, and three new saponins melongoside N, O and P, have been isolated from seeds. [9] Catechol oxidase has been isolated and characterised from Solanum melongena. [10] A bioflavonoid glycoside named solanoflavone is present in the leaves and fruits of Solanum melongena.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological activities of Solanum melongena Linn. (Brinjal plant)

Das¹,

Barua²

2013

Int J Green Pharm

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NMR spectroscopy of steroidal sapogenins and steroidal saponins: An update

Agrawal

Jain

Pathak

1995

Magnetic Reson in Chemistry

113

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The I3C NMR chemical shifts of 126 steroidal sapogenins published between 1983 and 1993 are listed and critical spectral features and advances made in the NMR characterization of these compounds are discussed as a guide for the identification of the parent skeleton and the determination of substitution patterns. The NMR spectroscopic methods applicable to deduce the complete structure of the oligosaccharide moiety and its linkage to the sapogenin residue are also presented to elucidate the structure of steroidal saponins.

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Melongosides n, o and p: steroidal saponins from seeds of solanum melongena

Cited by 23 publications

References 5 publications

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Pharmacological activities of Solanum melongena Linn. (Brinjal plant)

NMR spectroscopy of steroidal sapogenins and steroidal saponins: An update

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