Melt Electrowriting of Nylon‐12 Microfibers with an Open‐Source 3D Printer

Reizabal, Ander; Devlin, Brenna L.; Paxton, Naomi C.; Saiz, Paula G.; Liashenko, Ievgenii; Luposchainsky, Simon; Woodruff, Maria A.; Lanceros‐Mendez, Senentxu; Dalton, Paul D.

doi:10.1002/marc.202300424

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…This behavior is commonly referred to as J-Shape Stress-Strain behavior or nonlinear viscoelastic behavior of stress stiffening. [30,[79][80][81] Replicating this characteristic is a benchmark for synthetic vascular grafts to reduce the mechanical mismatch and allow the grafted tubular structure to better incorporate into the physiological tissue and minimize the risk of inducing a rapid graft occlusion due to blood flow disturbances and the resulting accumulation of platelets at the grafting site. [6,8] Artificial grafts need to replicate Challenges of the field of small diameter vascular grafts.…”

Section: The Mechanical Reference: Nonlinear Viscoelastic Behavior Of...mentioning

confidence: 99%

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Bartolf‐Kopp,

Jungst

2024

Adv Healthcare Materials

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Melt Electrowriting (MEW) is a continuously growing manufacturing platform. Its advantage is the consistent production of micro‐ to nanometer fibers, that stack intricately, forming complex geometrical shapes. MEW allows tuning of the mechanical properties of constructs via the geometry of deposited fibers. Due to this, MEW can create complex mechanics only seen in multi‐material compounds and serve as guiding structures for cellular alignment. The advantage of MEW is also shown in combination with other biotechnological manufacturing methods to create multilayered constructs that increase mechanical approximation to native tissues, biocompatibility, and cellular response. These features make MEW constructs a perfect candidate for small‐diameter vascular graft structures. Recently, studies have presented fascinating results in this regard, but is this truly the direction that tubular MEW will follow or are there also other options on the horizon? This perspective will explore the origins and developments of tubular MEW and present its growing importance in the field of artificial small‐diameter vascular grafts with mechanical modulation and improved biomimicry and the impact of it in convergence with other manufacturing methods and how future technologies like AI may influence its progress.

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Section: The Mechanical Reference: Nonlinear Viscoelastic Behavior Of...mentioning

confidence: 99%

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Bartolf‐Kopp,

Jungst

2024

Adv Healthcare Materials

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Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

Devlin,

Allenby,

Ren

et al. 2024

Adv Funct Materials

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The field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for applications in tissue engineering and beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, and dynamic culture systems offers promising new opportunities to gain deeper insights into complex biological systems. As the focus shifts towards personalized medicine and reduced reliance on animal models, the multidisciplinary approach becomes indispensable. This review provides a concise overview of current strategies and innovations in controlling and optimizing cellular responses to MEW scaffolds, highlighting the potential of scaffold material, MEW architecture, and computational modeling tools to accelerate the development of efficient biomimetic systems. Innovations in material science and the incorporation of biologics into MEW scaffolds have shown great potential in adding biomimetic complexity to engineered biological systems. These techniques pave the way for exciting possibilities for tissue modeling and regeneration, personalized drug screening, and cell therapies.

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Materials and Strategies to Enhance Melt Electrowriting Potential

Saiz,

Reizabal,

Vilas‐Vilela

et al. 2024

Advanced Materials

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Melt electrowriting (MEW) is an emerging additive manufacturing (AM) technology that enables the precise deposition of continuous polymeric microfibers, allowing for the creation of high‐resolution constructs. In recent years, MEW has undergone a revolution, with the introduction of active properties or additional functionalities through novel polymer processing strategies, the incorporation of functional fillers, post‐processing, or the combination with other techniques. While extensively explored in biomedical applications, MEW's potential in other fields remains untapped. Thus, this review explores MEW's characteristics from a materials science perspective, emphasizing the diverse range of materials and composites processed by this technique and their current and potential applications. Additionally, the prospects offered by post‐printing processing techniques are explored, together with the synergy achieved by combining melt electrowriting with other manufacturing methods. By highlighting the untapped potentials of MEW, this review aims to inspire research groups across various fields to leverage this technology for innovative endeavors.This article is protected by copyright. All rights reserved

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Melt Electrowriting of Nylon‐12 Microfibers with an Open‐Source 3D Printer

Cited by 8 publications

References 22 publications

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

Materials and Strategies to Enhance Melt Electrowriting Potential

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