Melt pelletization in a high shear mixer. IX. Effects of binder particle size

Schæfer, Torben; Mathiesen, Christina

doi:10.1016/0378-5173(96)04548-6

Cited by 132 publications

(43 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding binder initial particle size, PCA confirmed what was observed in preliminary studies and reported in literature about the relevance of this parameter in melt granulation and also about the convenience of choosing a small initial particle size for these excipients (Schaefer, Mathiesen, 1996). The starch granulate obtained with PEG 6000 milled through a 1 mm sieve (P6) was located in the upper left of the biplot in Figure 1.…”

Section: Pca Of Granulatessupporting

confidence: 72%

Application of multivariate techniques in the evaluation of melt granulation products

Andrade

2011

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

In this work, principal component analysis and cluster analysis were applied as helping tools to extract useful information in the development of formulations and manufacturing processes of melt granulates. Two melt granulation processes that differ in the shear stress applied to the solid bed during melting step were designed. These processes employ equipment frequently used in the local pharmaceutical industry. The selected binders include both hydrophilic and hydrophobic excipients, which were used alone or in binary mixtures. Granulates were characterized regarding their physicomechanical properties, including their compaction behavior. The resulting tablets were also evaluated. The selected multivariate statistical methods proved to be useful in facilitating the interpretation of the collected data and the study of the properties of granulates and tablets, as well as the selection of more efficient production processes.Uniterms: Granulates/evaluation. Tablets/evaluation. Granulates/manufacturing processes. Melt granulates/manufacturing processes. Tablets/production processes. Principal component analysis/ application. Cluster analysis/application. Pharmaceutical formulations/development. Melt granulation/ application.Neste trabalho, foram aplicadas as técnicas de análise de componentes principais e de análise de agrupamentos para extrair informações úteis no desenvolvimento de formulações e de processos de produção de granulados por fusão. Desenharam-se dois processos de granulação por fusão que apresentam diferenças na tensão de cisalhamento aplicada ao leito sólido durante a etapa de fusão. Esses processos empregam equipamentos frequentemente usados na indústria farmacêutica local. Os ligantes escolhidos incluíram excipientes tanto hidrofílicos quanto hidrofóbicos, utilizados de forma individual ou em misturas binárias. Os granulados foram caracterizados quanto às suas propriedades físico-mecânicas, incluindo seu desempenho no processo de compactação. Os comprimidos resultantes também foram avaliados. Os métodos de análise multivariada escolhidos provaram ser úteis para facilitar a interpretação dos dados coletados e o estudo das propriedades dos granulados e dos comprimidos, bem como a seleção de processos de produção mais eficientes.

show abstract

Section: Pca Of Granulatessupporting

confidence: 72%

Application of multivariate techniques in the evaluation of melt granulation products

Andrade

2011

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Similar experiments with the same materials and devices were performed by Scott (2000). Schaefer and Mathiesen (1996) confirmed that the increase in binder particle size was associated with the increase in initial size of nuclei and with the subsequent growth rate of granules. The uniformity of binder distribution deteriorates with an increase in its viscosity, which results in a broad or even bimodal distribution of granule size.…”

Section: Introductionsupporting

confidence: 68%

“…Vonk (1997) cpe.czasopisma.pan.pl; degruyter.com/view/j/cpe showed that nucleation mechanism is influenced by the quotient of droplet size and basic dimensions of powder particles. Schaefer and Mathiesen (1996) proposed two different mechanisms of nucleation, depending on the relative size of droplets and raw material particles: distribution mechanism and immersion mechanism. The aforementioned mechanisms describing granulation process have been extended to wet granulation in high-speed mixers by Scott et al (2000).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Disaccharide Concentration in a Liquid Binder on The Mechanisms and Kinetics of Disc Granulation

Obraniak

Gluba

2017

Chemical and Process Engineering

View full text Add to dashboard Cite

Analysis of granulation kinetics was carried out using a laboratory disc granulator with a diameter D of 0.5 m. A liquid binder was delivered to the tumbling bed at a constant flow rate with a nozzle generating droplets with a size of approx. 4-5 mm. Fine-grained chalk was used as a model of raw material and water or disaccharide solution with concentrations of 20 -40% as a wetting liquid. Different times of droplet delivery ranging from 2 to 6 min were utilized. Granulometric composition of the bed for selected lengths of process, bed moisture and the moisture of individual size-fractions were assessed. Mass of granulated material, which was transferred from nuclei fraction to other size fractions was determined on the basis of mass balance analysis and the assessment of liquid migration between fractions. The influence of disaccharide concentration in wetting liquid on the aforementioned phenomena was also examined.

show abstract

“…For melt pelletisation in a high shear mixer Schaefer and Mathiesen (1996) proposed two different nucleation mechanisms, depending on the relative size of droplets and particles.…”

Section: Introductionmentioning

confidence: 99%

A Model of agglomerate formation during bed wetting in the process of disc granulation

Obraniak¹,

Gluba²

2012

Chemical and Process Engineering

View full text Add to dashboard Cite

This paper presents a method for quantitative assessment of the mechanisms of nucleation and granules growth by layering in the process of bed wetting during periodic disc granulation. This study included two initial, consecutive stages of a process with defined time courses. The first phase was a time period, in which only formation of new nuclei took place, while in the second stage simultaneous nucleation and growth of granules as a result of sticking raw material grains to preexisting nuclei occurred. Different kinds of binding liquid were used for bed wetting in each phase. In the first phase, an aqueous solution of dye was used, and pure distilled water in the second stage. The contribution of particular mechanisms to the formation of agglomerates at different time points within the second phase of the process was determined in this study. To do that the results of bed granulometric analysis, mass balance of size fractions and the analysis of contents of a marker (dye) delivered to the bed with the binding liquid during the first phase in agglomerates were used. To assess the concentration of the dye in different size fractions of the batch, spectrophotometric analysis was utilised. The study was performed using UV-VIS JASCO V-630 spectrophotometer equipped with an integrating sphere. The sieve analysis, spectrophotometric studies and mass balance were used to determine changes in the weight of the dye containing nuclei and of the nuclei containing no dye. The aforementioned analyses were also used to assess changes in the weight of formed granules and of raw material particles attached to nuclei during simultaneous nucleation and growth of granules.

show abstract

Melt pelletization in a high shear mixer. IX. Effects of binder particle size

Cited by 132 publications

References 11 publications

Application of multivariate techniques in the evaluation of melt granulation products

Application of multivariate techniques in the evaluation of melt granulation products

The Effect of Disaccharide Concentration in a Liquid Binder on The Mechanisms and Kinetics of Disc Granulation

A Model of agglomerate formation during bed wetting in the process of disc granulation

Contact Info

Product

Resources

About