Here, we scrutinize the entropy analysis in magnetohydrodynamic flow of second-grade nanomaterials with melting effect subject to stretchable bended surface. Heat attribution is modeled through first law of thermodynamics with radiation effect. Major physical effect of random and thermophoretic motion is also addressed. Feature of irreversibility (entropy rate) analysis is also discussed. Isothermal cubic autocatalyses chemical reaction at catalytic surface is discussed. Nonlinear dimensionless differential system is developed through adequate transformation. Optimal homeotypic analysis method (OHAM) is employed to construct convergent solution. Influence of physical variables on entropy rate, fluid flow, concentration, and thermal field is discussed. An augmentation in fluid flow is noticed through curvature variable, while reverse effect holds for magnetic variable. A reverse effect holds for fluid flow and thermal field through melting variable. Entropy analysis is augmented with variation in melting variable. Reduction occurs in concentration through thermophoretic variable, while an opposite effect holds for thermal field. An increment in melting variable leads to reduced concentration. Larger estimation of radiation variable improves entropy analysis.