Memantine treatment of juvenile rats with kaolin-induced hydrocephalus

Curzio, Domenico L. Di; Nagra, Gurjit; Mao, Xiaoyan; Bigio, Marc R. Del

doi:10.1016/j.brainres.2018.04.001

Cited by 3 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As over 70% of Neu5Ac in the brain constitutes gangliosides, the essential components of myelin, 27 decreased conjugated Neu5Ac in both humans and mice reportedly resulted in demyelination 28,29 . In NPH patients and hydrocephalic mice, along with astrogliosis, demyelination has also been reported 14,22 . Demyelination contributes to the neuropathological and clinical symptoms of NPH 23 .…”

Section: Introductionmentioning

confidence: 99%

“…Demyelination contributes to the neuropathological and clinical symptoms of NPH 23 . Inhibiting demyelination in hydrocephalus has been proven to be beneficial to cognitive and motor symptoms 22 . Considering that increasing Neu5Ac upregulates many myelination‐responsive genes, including MBP, 30,31 the effect of Neu5Ac on the rescue of hydrocephalus‐induced demyelination and related neurological deficits needs to be explored.…”

Section: Introductionmentioning

confidence: 99%

“…In the brain, decreased conjugated Neu5Ac can lead to increased infiltration and activation of astrocytes, which is also evident in untreated NPH patients and hydrocephalic mice. 14 , 22 In NPH, astrogliosis is believed to decrease intracranial compliance and affect shunt response. 23 Recent studies have shown that reactive astrocytes exist after brain injuries in the A1 and A2 forms.…”

Section: Introductionmentioning

confidence: 99%

“…28,29 In NPH patients and hydrocephalic mice, along with astrogliosis, demyelination has also been reported. 14,22 Demyelination contributes to the neuropathological and clinical symptoms of NPH 23 . Inhibiting demyelination in hydrocephalus has been proven to be beneficial to cognitive and motor symptoms.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Increasing brain N‐acetylneuraminic acid alleviates hydrocephalus‐induced neurological deficits

Wang,

Nie,

Gao

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

AimsThis metabolomic study aimed to evaluate the role of N‐acetylneuraminic acid (Neu5Ac) in the neurological deficits of normal pressure hydrocephalus (NPH) and its potential therapeutic effect.MethodsWe analyzed the metabolic profiles of NPH using cerebrospinal fluid with multivariate and univariate statistical analyses in a set of 42 NPH patients and 38 controls. We further correlated the levels of differential metabolites with severity‐related clinical parameters, including the normal pressure hydrocephalus grading scale (NPHGS). We then established kaolin‐induced hydrocephalus in mice and treated them using N‐acetylmannosamine (ManNAc), a precursor of Neu5Ac. We examined brain Neu5Ac, astrocyte polarization, demyelination, and neurobehavioral outcomes to explore its therapeutic effect.ResultsThree metabolites were significantly altered in NPH patients. Only decreased Neu5Ac levels were correlated with NPHGS scores. Decreased brain Neu5Ac levels have been observed in hydrocephalic mice. Increasing brain Neu5Ac by ManNAc suppressed the activation of astrocytes and promoted their transition from A1 to A2 polarization. ManNAc also attenuated the periventricular white matter demyelination and improved neurobehavioral outcomes in hydrocephalic mice.ConclusionIncreasing brain Neu5Ac improved the neurological outcomes associated with the regulation of astrocyte polarization and the suppression of demyelination in hydrocephalic mice, which may be a potential therapeutic strategy for NPH.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Increasing brain N‐acetylneuraminic acid alleviates hydrocephalus‐induced neurological deficits

Wang,

Nie,

Gao

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Recent interest in rodent imaging has focused on FC imaging, using rs-fMRI, with the motivation to understand the functional reorganization taking place in murine models of brain disorders ranging from Alzheimer's disease [9] [10] [11] [12] to autism and depression [13] [14]. However, previous research on hydrocephalus has mainly focused on anatomical measures of white matter integrity and myelination [15] [16]. To date, there is a lack of research investigating functional consequences in this condition.…”

Section: Introductionmentioning

confidence: 99%

Preserved functional networks in a hydrocephalic mouse

Mandino

Yeow

Gigg

et al. 2019

Matters

View full text Add to dashboard Cite

Hydrocephalus is a brain condition characterized by enlarged ventricles, due to an excess of cerebrospinal fluid. Although it is known to affect cognition, development, gait, and mood, the impact of hydrocephalus on large-scale functional brain organization is poorly documented. Here, we present results on a single spontaneous occurrence of severe hydrocephalus observed in a 3xTgAD mouse, compared to a control cohort of 3xTgAD littermates. Resting-state functional magnetic resonance imaging analysis, carried out under light anesthesia, revealed the remarkable presence of functional connectivity (FC) resembling the common mouse resting-state networks (RSNs). Four main components were identified in the hydrocephalic mouse, attributable to the Default Mode network, Salience network, and sensorimotor networks. Characteristic features of the RSNs in the hydrocephalic mouse were found to be well preserved, both in spatial distribution and in FC magnitude, despite the severity of the pathology. This is the first documented case of resting-state fMRI conducted on a mouse affected by severe hydrocephalus. The surprising presence of resting-state networks was found to be comparable to littermate controls, highlighting a remarkable functional resilience in the hydrocephalic brain.

show abstract

Hydrocephalus: A Review of Etiology Driven Treatment Strategies

Arianna Mirkhaef,

Harbaugh,

Nagra

2024

New Insights on Cerebrospinal Fluid

View full text Add to dashboard Cite

Hydrocephalus is a broad term usually understood as cerebrospinal fluid (CSF) accumulation resulting in cerebral ventricular system expansion. The production of CSF is by the choroid plexus in lateral ventricles, flowing between the third and fourth ventricles and eventually to the subarachnoid space. It is critical for proper neuronal function. Hydrocephalus is a neurological pathology linked to high morbidity from neurocognitive and motor impairment. It is classified as either communicating or non-communicating. Communicating hydrocephalus is understood as a deficit at cranial arachnoid villi and granulation absorption sites. However, there has been evidence that extracranial lymphatic vessels in the ethmoid bone region also play a role indicated by decreased lymphatic absorption in rat models of hydrocephalus. Treatment typically involves surgical shunt placement or endoscopic third ventriculostomy (ETV) technique with or without choroid plexus cauterization (CPC). These surgical interventions have high failure risks and complications that require re-intervention, further increasing morbidity and mortality risks. To date, there are few nonsurgical treatment strategies, but many have proved limited benefit, and many patients still require surgery. This analysis lays out the typical treatments and explores new, innovative interventions by highlighting the active role of brain parenchymal tissue in the pathogenesis of hydrocephalus.

show abstract

Memantine treatment of juvenile rats with kaolin-induced hydrocephalus

Cited by 3 publications

References 41 publications

Increasing brain N‐acetylneuraminic acid alleviates hydrocephalus‐induced neurological deficits

Increasing brain N‐acetylneuraminic acid alleviates hydrocephalus‐induced neurological deficits

Preserved functional networks in a hydrocephalic mouse

Hydrocephalus: A Review of Etiology Driven Treatment Strategies

Contact Info

Product

Resources

About