Members of the OSBP Homologue (Osh) Protein Family in S. cerevisiae Require Specific Lipids to Regulate Polarized Exocytosis

Abstract

The Oxysterol Binding Proteins (OSBPs) are an evolutionarily conserved protein family in eukaryotes implicated in many cellular functions. One function, supported by a large body of in vitro data is lipid transfer between membranes. In addition, in vivo changes in lipid distribution among cellular membranes have been shown to be OSBP dependent, further suggesting a role for OSBPs in lipid homeostasis. Despite these Section 1: Polarized Exocytosis 1 Exocytosis in S. cerevisiae 2 Polarized Exocytosis 5 Lipids Involved in Polarized Exocytosis Membrane-Membrane Contact Section 2: What Essential Functions are Provided by the Oxysterol Binding Proteins? Oxysterol Binding Protein Structure OSBPs in Human Disease Lipid Binding and Transfer Activity of the OSBPs Other Functions of the Oxysterol Binding Protein Family Oxysterol Binding Protein Activity in Polarized Exocytosis iii Chapter 2: Lipid-Dependent Regulation of Exocytosis in S. cerevisiae by OSBP Homologue (Osh) 4