Membrane Association for Plant Virus Replication and Movement

Jiang, Jianan; Laliberté, Jean‐François

doi:10.1007/978-3-319-32919-2_3

Cited by 10 publications

(13 citation statements)

References 100 publications

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“…Those host-derived membranes serve as scaffolds for the assembly of ‘viral factories,’ which provide a platform for anchoring the viral replication complexes (VRCs) and create a protected environment for RNA synthesis and viral genome encapsidation. Some virus factories have been shown to associate with and traffic along microfilaments, and may be involved in other processes such as viral RNA (vRNA) translation and cell-to-cell virus transport ( Armas-Rillo et al, 2016 ; Jiang and Laliberté, 2016 ). The closterovirus DMVs and MVCs appear similar to the vesicles found for other plant and animal virus infections, such as those for Turnip mosaic virus (TuMV), Potato virus X (PVX), Hepatitis C virus (HCV) and Poliovirus (PV) ( Romero-Brey and Bartenschlager, 2014 ; Jiang and Laliberté, 2016 ).…”

Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

“…Some virus factories have been shown to associate with and traffic along microfilaments, and may be involved in other processes such as viral RNA (vRNA) translation and cell-to-cell virus transport ( Armas-Rillo et al, 2016 ; Jiang and Laliberté, 2016 ). The closterovirus DMVs and MVCs appear similar to the vesicles found for other plant and animal virus infections, such as those for Turnip mosaic virus (TuMV), Potato virus X (PVX), Hepatitis C virus (HCV) and Poliovirus (PV) ( Romero-Brey and Bartenschlager, 2014 ; Jiang and Laliberté, 2016 ). The formation and functional mechanisms of the vesiculated closterovirus inclusion bodies are not get understood.…”

Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

“…They are also found present in phloem SE and xylem vessels as a form for long-distance movement ( Wan et al, 2015b ). Other plant viruses that induce ER-derived vesicles include Cowpea mosaic virus (CPMV), Grapevine fanleaf virus (GFLV), PVX, Tomato mosaic virus (ToMV), etc ( Jiang and Laliberté, 2016 ).…”

Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

“…These features made viruses in the family Closteroviridae difficult to study. Although it has been realized that the virus-induced cytopathic changes in host cells often have various functions in viral replication, RNA translation and/or cell-to-cell transport ( Miller and Krijnse-Locker, 2008 ; Laliberté and Sanfaçon, 2010 ; Jiang and Laliberté, 2016 ), however, relevant studies of closteroviruses have been more limited compared to those for other plant viruses. In this review, we provide an overview of the cellular modifications induced during closterovirus infection, especially those induced by Lettuce infectious yellows virus (LIYV), the type member of the genus Crinivirus in the family Closteroviridae ( Wang et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

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Inspirations on Virus Replication and Cell-to-Cell Movement from Studies Examining the Cytopathology Induced by Lettuce infectious yellows virus in Plant Cells

2017

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Lettuce infectious yellows virus (LIYV) is the type member of the genus Crinivirus in the family Closteroviridae. Like many other positive-strand RNA viruses, LIYV infections induce a number of cytopathic changes in plant cells, of which the two most characteristic are: Beet yellows virus-type inclusion bodies composed of vesicles derived from cytoplasmic membranes; and conical plasmalemma deposits (PLDs) located at the plasmalemma over plasmodesmata pit fields. The former are not only found in various closterovirus infections, but similar structures are known as ‘viral factories’ or viroplasms in cells infected with diverse types of animal and plant viruses. These are generally sites of virus replication, virion assembly and in some cases are involved in cell-to-cell transport. By contrast, PLDs induced by the LIYV-encoded P26 non-virion protein are not involved in replication but are speculated to have roles in virus intercellular movement. These deposits often harbor LIYV virions arranged to be perpendicular to the plasma membrane over plasmodesmata, and our recent studies show that P26 is required for LIYV systemic plant infection. The functional mechanism of how LIYV P26 facilitates intercellular movement remains unclear, however, research on other plant viruses provides some insights on the possible ways of viral intercellular movement through targeting and modifying plasmodesmata via interactions between plant cellular components and viral-encoded factors. In summary, beginning with LIYV, we review the studies that have uncovered the biological determinants giving rise to these cytopathological effects and their importance in viral replication, virion assembly and intercellular movement during the plant infection by closteroviruses, and compare these findings with those for other positive-strand RNA viruses.

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Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

Section: Virus-induced Membrane Modificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inspirations on Virus Replication and Cell-to-Cell Movement from Studies Examining the Cytopathology Induced by Lettuce infectious yellows virus in Plant Cells

2017

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“…Most positive-strand RNA viruses replicate their genomes in association with membrane structures derived from the ER and GA or from membrane-bound organelles ( Verchot, 2011 ; Grangeon et al, 2012 ; Romero-Brey and Bartenschlager, 2014 ). This association leads to cytological modifications that cause a great impact within the cell by producing membranous compartments that, even morphologically different, can support viral complex assembling and replication ( Jiang and Laliberté, 2016 ). The most remarkable cytological modification induced by carmoviruses is frequently related to mitochondria alterations.…”

Section: Replication and Movement Connection In Carmovirusmentioning

confidence: 99%

An Update on the Intracellular and Intercellular Trafficking of Carmoviruses

Navarro

Pallás

2017

Front. Plant Sci.

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Despite harboring the smallest genomes among plant RNA viruses, carmoviruses have emerged as an ideal model system for studying essential steps of the viral cycle including intracellular and intercellular trafficking. Two small movement proteins, formerly known as double gene block proteins (DGBp1 and DGBp2), have been involved in the movement throughout the plant of some members of carmovirus genera. DGBp1 RNA-binding capability was indispensable for cell-to-cell movement indicating that viral genomes must interact with DGBp1 to be transported. Further investigation on Melon necrotic spot virus (MNSV) DGBp1 subcellular localization and dynamics also supported this idea as this protein showed an actin-dependent movement along microfilaments and accumulated at the cellular periphery. Regarding DGBp2, subcellular localization studies showed that MNSV and Pelargonium flower break virus DGBp2s were inserted into the endoplasmic reticulum (ER) membrane but only MNSV DGBp2 trafficked to plasmodesmata (PD) via the Golgi apparatus through a COPII-dependent pathway. DGBp2 function is still unknown but its localization at PD was a requisite for an efficient cell-to-cell movement. It is also known that MNSV infection can induce a dramatic reorganization of mitochondria resulting in anomalous organelles containing viral RNAs. These putative viral factories were frequently found associated with the ER near the PD leading to the possibility that MNSV movement and replication could be spatially linked. Here, we update the current knowledge of the plant endomembrane system involvement in carmovirus intra- and intercellular movement and the tentative model proposed for MNSV transport within plant cells.

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A single substitution inVacuolar protein sorting 4is responsible for resistance toWatermelon mosaic virusin melon

Agaoua

Rittener

Desbiez

et al. 2022

Journal of Experimental Botany

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In plants, introgression of genetic resistances is a proven strategy for developing new resistant lines. While host proteins involved in genome replication and cell-to-cell movement are widely studied, other cell mechanisms responsible for virus infection remain underestimated. Endosomal sorting complexes required for transport (ESCRT) play a key role in membrane trafficking in plants and are involved in the replication of several plant RNA viruses. In this work, we describe the role of the ESCRT protein CmVPS4 as a new susceptibility factor to the Potyvirus watermelon mosaic virus (WMV) in melon. Using a worldwide collection of melons, we identified three different alleles carrying non-synonymous substitutions in CmVps4. Two of these alleles were shown to be associated with WMV resistance. Using a complementation approach, we demonstrated that resistance is due to a single non-synonymous substitution in the allele CmVps4P30R. This work opens new avenues of research on a new family of host factors required for virus infection and new targets for resistance.

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Membrane Association for Plant Virus Replication and Movement

Cited by 10 publications

References 100 publications

Inspirations on Virus Replication and Cell-to-Cell Movement from Studies Examining the Cytopathology Induced by Lettuce infectious yellows virus in Plant Cells

Inspirations on Virus Replication and Cell-to-Cell Movement from Studies Examining the Cytopathology Induced by Lettuce infectious yellows virus in Plant Cells

An Update on the Intracellular and Intercellular Trafficking of Carmoviruses

A single substitution inVacuolar protein sorting 4is responsible for resistance toWatermelon mosaic virusin melon

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