Membrane Biochemistry of Vascular Smooth Muscle of Resistance Blood Vessels and Changes in Hypertension

Kwan, Chiu‐Yin

doi:10.1007/978-1-4612-0403-9_17

Cited by 3 publications

(1 citation statement)

References 77 publications

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“…I perfected the biochemical methods in the isolation of biological membranes, especially from tissues with sparse smooth muscle content as blood vessels (Grover et al 1980;Kwan et al 1979aKwan et al , 1983aKwan et al , 1983bKwan et al , 1984Kwan 1985). Over these years, Dr. Daniel and I published a few landmark methodological reviews on the control of Ca 2+ in smooth muscle (Kwan et al 1982;Kwan 1991Kwan , 1992Daniel et al 2001). Over these years, Dr. Daniel and I published a few landmark methodological reviews on the control of Ca 2+ in smooth muscle (Kwan et al 1982;Kwan 1991Kwan , 1992Daniel et al 2001).…”

Section: Control Of Vsm Via Cellular Ca 2+ -Perspectives As a Cell Phmentioning

confidence: 99%

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

Kwan¹

2005

Can. J. Physiol. Pharmacol.

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This communication is neither a comprehensive review of my research, nor a description about my recent new original scientific findings in smooth muscle or in cell Ca2+. For that intention, I will choose to publish via a regular channel, certainly not in this special edition. My intention is to take this opportunity to recapitulate Dr. Daniel's thoughts and spirits through the progress of my research, teaching, and personal development at McMaster University, stemming largely from Dr. Daniel's life-long interest in the regulation of Ca2+ in the control of smooth muscle function, specifically the vascular smooth muscle. Being a culturally adsorbent person, I am sure that my thoughts and behavior must have been substantially influenced by Dr. Daniel over 27 years of our collaboration. His influence may have molded me into whom and what I am today, both socially and scientifically. Equally, I may also have influenced him in some particular or peculiar way. Dr. Daniel's academic contribution is globally well known for, but not limited to, his insightful and productive research in smooth muscle, but also for his effective application of problem-based learning to education in pharmacology and his influence on students and colleagues.

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Section: Control Of Vsm Via Cellular Ca 2+ -Perspectives As a Cell Phmentioning

confidence: 99%

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

Kwan¹

2005

Can. J. Physiol. Pharmacol.

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Plant‐derived drugs acting on cellular ca ²⁺ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine

Kwan

1994

STEM CELLS

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The pharmacological profiles of the active ingredients extracted and purified from two well-known Chinese traditional medicinal plants were reviewed. These herbal drugs include tetramethylpyrazine (TMP) and tetrandrine (TET); both have been clinically used in China for the treatment of cardiovascular diseases due to their vasodilatory actions. Studies from this laboratory have confirmed previously reported characteristics of TMP as a Ca2+ antagonist in vascular tissues. However, it also elicited inhibitory effects in response to a wide variety of receptor stimulations as indicated by functional studies and radioligand binding studies using isolated subcellular membranes. TET also inhibited the vascular contraction in response to depolarization by KCl and phenylephrine. It has been found to interact directly with the L-type Ca2+ channel and alpha-adrenoceptor subtypes. Recently, its action on T-type Ca2+ channels has also been demonstrated. These findings collectively suggest that studies of the vasodilatory and antihypertensive effects of these plant-derived drugs on the regulation of cytosolic Ca2+ in vascular smooth muscle are consistent with the current hypothesis of Ca2+ dysfunction as an important etiological factor for the pathogenesis of hypertension.

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In Vitro Small Artery Methodology

Brayden¹

1994

The Human Brain Circulation

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Membrane Biochemistry of Vascular Smooth Muscle of Resistance Blood Vessels and Changes in Hypertension

Cited by 3 publications

References 77 publications

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

Plant‐derived drugs acting on cellular ca ²⁺ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine

In Vitro Small Artery Methodology

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Membrane Biochemistry of Vascular Smooth Muscle of Resistance Blood Vessels and Changes in Hypertension

Cited by 3 publications

References 77 publications

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

Plant‐derived drugs acting on cellular ca 2+ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine

In Vitro Small Artery Methodology

Contact Info

Product

Resources

About

Plant‐derived drugs acting on cellular ca ²⁺ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine