Membrane Blood Group Antigens and Antibodies

Reid, Marion E.; Westhoff, Connie M.

doi:10.1016/b978-0-443-06981-9.50010-7

Cited by 4 publications

(5 citation statements)

References 124 publications

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“…In this way, the interaction of mHEL RBCs with monoclonal anti-HEL mimics "clinically insignificant" human blood group antigens, for which crossmatch-incompatible RBCs can be transfused without hemolysis (ie, JMH, Chido-Rodgers, Knops). 22 Taken together, our data indicate that antigen loss depends on the cooperative interaction of more than one anti-HEL antibody.…”

Section: Individual Monoclonal Anti-hel Antibodies Did Not Induce Antmentioning

confidence: 71%

“…Several human blood group antigens are not "clinically significant" and do not result in hemolysis when transfused into crossmatchincompatible patients (ie, JMH, Chido-Rodgers, Knops). 22 It may be that mHEL more closely resembles such antigens. This may provide mHEL RBCs additional time for antigen loss to occur, resulting in a model in which antigen loss is more easily observed.…”

Section: Discussionmentioning

confidence: 99%

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Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

Zimring

Cadwell

Chadwick

et al. 2007

Blood

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Section: Individual Monoclonal Anti-hel Antibodies Did Not Induce Antmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

Zimring

Cadwell

Chadwick

et al. 2007

Blood

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“…Since the fucose moiety is a necessary precursor for the A and B antigens, Bombay blood will type as O, but will have hemolytic auto-antibodies to the H antigen. 3 Identification of the Bombay phenotype occurs during the antibody screen interpretation of blood. 11 The patient will appear to have group O blood, but all type O blood will be reactive to the patient's plasma.…”

Section: Discussionmentioning

confidence: 99%

“…Red blood cell transfusions for persons with Bombay phenotype must be either autologous or from another Bombay phenotype donor. 3 CBS would normally require a minimum of 24 hr to obtain red blood cells from local compatible donors or to locate and obtain frozen units through their national database.…”

Section: Discussionmentioning

confidence: 99%

“…É léments cliniques Un homme d'origine indienne s'est pre´sente´a`l'hôpital avec des symptômes de score IV sur l'e´chelle de la New York Heart Association. 3 prompting Canadian Blood Services (CBS) to initiate a search of their national database for frozen units and/or compatible donors. Fortunately, persons with Bombay phenotype may receive other blood products, including fresh frozen plasma, cryoprecipitate, platelets, prothrombin complex concentrate, and recombinant activated factor VIIa.…”

Section: Résumémentioning

confidence: 99%

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Urgent replacement of a mechanical mitral prosthesis in an anticoagulated patient with Bombay red blood cell phenotype

Nairn

Giulivi

Neurath

et al. 2010

Can J Anesth/J Can Anesth

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Immune erythrocyte antibodies in adult patients with sickle cell disease and blood donors in Lagos, Nigeria: a comparative study

et al. 2021

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Sickle cell disease (SCD) poses a major public health challenge in sub-Saharan Africa, including Nigeria. Blood transfusion is a mainstay in SCD treatment. Erythrocyte alloimmunization is known to complicate the transfusional care of patients with SCD. Immune alloantibodies are associated with hemolytic transfusion reactions and transfusion refractoriness. We aimed to determine the prevalence, specificities, and clinical associations/ risk factors of immune erythrocyte alloantibodies among adult patients with SCD compared with healthy blood donors in Lagos, Nigeria, through a cross-sectional study. All participants were interviewed using a structured questionnaire to obtain details on bio-data, hemoglobin phenotype, blood transfusion history, and SCD history where relevant. Blood specimens obtained from each participant were subjected to antibody screening/identification using tube agglutination method. The mean age of the SCD participants and healthy blood donors was 27.92 and 29.04 years, respectively. The majority (72.5%) of the SCD participants had received at least 1 unit of red blood cell (RBC) transfusion in their lifetime, compared with only 7.5 percent of blood donors. Six SCD participants (7.5%) tested positive for atypical erythrocyte alloantibodies, with none among blood donors. Most of the antibodies (75%) belonged to the Rh blood group system. The most frequent antibody was anti-E, followed by anti-C and anti-D. Advancing age (30 years or more), recent transfusions (last 4 weeks), higher transfusion rates, and established renal disease were significantly associated with alloimmunization (p values of 0.026, 0.043, 0.002, and 0.043, respectively). This study suggests blood transfusion as a strong risk factor for RBC alloimmunization in SCD patients. Extended RBC phenotyping is recommended for all patients with SCD, especially those receiving regular transfusions.

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Membrane Blood Group Antigens and Antibodies

Cited by 4 publications

References 124 publications

Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

Urgent replacement of a mechanical mitral prosthesis in an anticoagulated patient with Bombay red blood cell phenotype

Immune erythrocyte antibodies in adult patients with sickle cell disease and blood donors in Lagos, Nigeria: a comparative study

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