“…These regulated vesicle fusion events are typically much slower than the Ca 2+ ‐triggered release of synaptic vesicles (Wickner & Schekman, 2008; Südhof & Rothman, 2009; Jahn & Fasshauer, 2012; Wollman & Meyer, 2012; Südhof, 2013) and require in addition to SNARE proteins signaling regulators such as protein kinase C (PKC) (Oancea & Meyer, 1998; Nechushtan et al , 2000; Newton, 2010). Despite decades of investigation, the role of PKC in vesicle secretion remains incompletely resolved (Nishizuka, 1986; Leitges et al , 1996; Kalesnikoff & Galli, 2008; Lorentz et al , 2012), but may involve incoherent feed‐forward regulation (Mangan & Alon, 2003) as PKC is known to both activate (Nechushtan et al , 2000; Newton, 2010) and suppress (McHugh et al , 2000; Leitges et al , 2002; Bousquet et al , 2010) numerous cell responses.…”