Membrane Ion Source for Mass Spectrometry

Yakovlev, B.S.; Talrose, V.L.; Fenselau, Catherine

doi:10.1021/ac00082a017

Cited by 34 publications

(29 citation statements)

References 7 publications

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“…It is likely that this type of membrane can be combined with either electrical fields, 7 laser desorption 6 or desorption chemical ionization to detect even large biomolecules. Here the major advantage as compared to other techniques such as electrospray will be the possibility to analyze complex samples (urine or even blood samples) without any pretreatment.…”

Section: Resultsmentioning

confidence: 99%

“…For example, Soni et al 6 developed a MIMS system using laser-stimulated desorption to assist the evaporation of nonvolatile hydrophobic compounds like indeno[1,2,3,-cd]pyrene (b.p. 530°C) from the membrane surface, and Yakovlev et al 7 developed a MIMS system using high electric fields to draw ions from solution through the membrane and into the mass spectrometer.…”

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Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

Ketola¹,

Lauritsen²

1999

Rapid Commun. Mass Spectrom.

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In order to detect highly polar organic compounds in water using membrane inlet mass spectrometry (MIMS), we designed a desorption chemical ionization ion source with a tubular polyacrylonitrile membrane positioned in the center of the chemical ionization (Cl) ion plasma. With this system we have for the first time been able to detect dicarboxylic acids (malonic and succinic acid) in aqueous samples with a MIMS system. The dicarboxylic acids were detected with both standard MIMS and trap-and-release MIMS methods. The trap-and-release MIMS method gave the best signal to noise ratio spectra with detection limits down to 50 mg/L. Although the results presented are very preliminary, they suggest that rapid detection or even on-line monitoring of this important group of biological metabolites might be possible with a MIMS system. Copyright # 1999 John Wiley & Sons, Ltd. Received 25 January 1999; Revised 18 February 1999; Accepted 19 February 1999 In the standard version of membrane inlet mass spectrometry (MIMS) a polymer membrane (silicone) is used as the only separation between a liquid sample and the mass spectrometer. Volatile organic compounds dissolve in the membrane, diffuse through it and evaporate into the ion source of the mass spectrometer, where they are ionized and analyzed. This transport process, called pervaporation, is highly specific and favors hydrophobic compounds. For example, hydrophobic compounds, such as the typical industrial solvents trichloroethene and toluene, can be measured at extremely low levels (parts-per-trillion), 1 whereas hydrophilic compounds like small carboxylic acid can only be detected at parts-per-million levels.2 Besides the preference for hydrophobic compounds, the standard MIMS method is useful only for determination of volatile compounds (boiling point below 200°C).Several researchers have worked on an expansion of the MIMS technique to include detection of less volatile and/or hydrophilic compounds.3 Thus far only the trap-and-release MIMS (T&R-MIMS) system 4,5 has successfully been used to detect compounds of both low volatility and relatively high polarity, such as acetylsalicylic acid, caffeine and pentachlorophenol. However, new and very promising techniques are under development at other laboratories. For example, Soni et al.6 developed a MIMS system using laser-stimulated desorption to assist the evaporation of nonvolatile hydrophobic compounds like indeno[1,2,3,-cd]pyrene (b.p. 530°C) from the membrane surface, and Yakovlev et al.7 developed a MIMS system using high electric fields to draw ions from solution through the membrane and into the mass spectrometer. In this paper we present the first results obtained with a system in which T&R-MIMS was combined with desorption chemical ionization (DCI). Desorption chemical ionization was developed in 1973 by Baldwin and McLafferty 8 as a method for the detection of involatile compounds (oligopeptides). In their experiments the sample was deposited as a dilute solution on the surface of the extended tip of a conventio...

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

Ketola¹,

Lauritsen²

1999

Rapid Commun. Mass Spectrom.

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“…3, напряженность экстрагирующего ионы электрического поля зависит от кривизны поверх-ности жидкости. Радиус ее кривизны, согласно [3,5], определяется из того условия, что давление, обусловлен-ное поверхностным натяжением, должно уравновеши-вать атмосферное давление и давление, обусловленное действием электрического поля. Оценки показывают, что для лавсановой мембраны с каналами диаметром около 60 nm, заполненными водно-глицериновой сме-сью, радиус кривизны поверхности жидкости в полях порядка 10 MV/cm будет существенно больше, чем радиус канала.…”

Section: обсуждение результатовunclassified

“…Впервые возможность создания условий для прямого полевого испарения ионов из полярного раствора без его разбрызгивания была продемонстрирована в [3]. Ста-билизация поверхности жидкости в сильном электриче-ском поле обеспечивалась за счет того, что содержащий ионы раствор помещали в каналы полимерной трековой мембраны толщиной около 10 µm, диаметр которых составлял несколько десятков нанометров.…”

Section: Introductionunclassified

Низковольтный Мембранный Интерфейс Для Экстракции Ионов Из Полярных Растворов

Балакин¹,

Буйдо²

2018

Журнал Технической Физики

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“…[1][2][3] Many new MIMS techniques have evolved from standard MIMS with the purpose of expanding the capabilities of MIMS with respect to the variety of compounds and samples that can be analyzed. For example Lauritsen et al 4 used porous membranes and solvent chemical ionization for the determination of organic compounds in organic matrices, and Yakovlev et al 5 used a strong electric field to drag ions from a liquid sample though a porous membrane into the mass spectrometer. Improved sensitivity has been examined through enrichment devices such as a jet separator, 6 a cold trap, 7 and solid adsorbents, 8,9 all of which were mounted between the membrane and the ion source.…”

mentioning

confidence: 99%

Temperature-programmed desorption for membrane inlet mass spectrometry

Ketola¹,

Grøn

Lauritsen³

1998

Rapid Commun. Mass Spectrom.

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We present a novel technique for analyzing volatile organic compounds in air samples using a solid adsorbent together with temperature-programmed desorption and subsequent detection by membrane inlet mass spectrometry (TPD-MIMS). The new system has the advantage of a fast separation of compounds prior to the detection by MIMS. The gaseous sample is simply adsorbed on the adsorbent, which is then rapidly heated from 30°C to 250°C at a rate of 50°C/min. Trapped organic compounds are released from the adsorbent into a helium stream at different temperatures depending on the strength of the interaction between the individual compound and the adsorbent. The helium stream carries the desorbed compounds to a membrane inlet (90°C) equipped with a thin (25 mm) silicone membrane. The thin membrane and the high temperature of the membrane inlet allows most volatile compounds to diffuse through the membrane into the mass spectrometer in a few seconds. In this fashion we could completely separate many similar volatile compounds, for example toluene from xylene and trichloroethene from tetrachloroethene. Typical detection limits were at low or sub-nanogram levels, the dynamic range was 3 orders of magnitude, and the analysis time for a mixture was about 3-4 minutes. # 1998 John Wiley & Sons, Ltd. Received 23 March 1998; Revised 17 April 1998; Accepted 20 April 1998 Membrane inlet mass spectrometry (MIMS) is an analytical method that allows detection of volatile organic compounds in water and air at low parts-per-billion and parts-per-trillion levels. The main advantages of the technique are the lack of pretreatment of samples before analysis, fast response times and on-line monitoring capabilities of water and air streams in biochemical and environmental systems. The most recent developments and applications of MIMS have been reviewed. [1][2][3] Many new MIMS techniques have evolved from standard MIMS with the purpose of expanding the capabilities of MIMS with respect to the variety of compounds and samples that can be analyzed. For example Lauritsen et al. 4 used porous membranes and solvent chemical ionization for the determination of organic compounds in organic matrices, and Yakovlev et al.5 used a strong electric field to drag ions from a liquid sample though a porous membrane into the mass spectrometer. Improved sensitivity has been examined through enrichment devices such as a jet separator, 6 a cold trap, 7 and solid adsorbents, 8,9 all of which were mounted between the membrane and the ion source. In affinity MIMS a chemically modified cellulose membrane was used to selectively adsorb aldehydes from a complex mixture.10 Recently, Lauritsen et al. 11,12 developed trapand-release MIMS, where less volatile (boiling point above 250°C) and relatively polar compounds were trapped inside the membrane itself, before they were thermally released into the ion source of the mass spectrometer.A major drawback of the MIMS system as compared to traditional analytical techniques like GC/MS and LC/MS is a lack of selectivity....

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Membrane Ion Source for Mass Spectrometry

Cited by 34 publications

References 7 publications

Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

Низковольтный Мембранный Интерфейс Для Экстракции Ионов Из Полярных Растворов

Temperature-programmed desorption for membrane inlet mass spectrometry

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