Membrane Microparticles: Two Sides of the Coin

Hugel, Bénédicte; Martinez, Maria Carmen; Kunzelmann, Corinne; Freyssinet, Jean‐Marie

doi:10.1152/physiol.00029.2004

Cited by 591 publications

(587 citation statements)

References 46 publications

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“…Furthermore, it has been recently shown that cells may transiently modify the phenotype of neighboring cells by transferring surface receptors, intracellular proteins, and mRNA in mechanisms that involve exchange of cell-membrane-derived microvesicles (Ratajczak et al, 2006a,b). Shedding of membrane-derived microvesicles is a physiological phenom-enon that accompanies cell growth and cell activation, for example, hypoxia or oxidative injury (Beaudoin and Grondin, 1991;VanWijk et al, 2003;Morel et al, 2004;Hugel et al, 2005 -galactosidase).…”

Section: Bm-derived Stem Cells and Tissue/organ Regeneration: Evidencmentioning

confidence: 99%

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Kucia

Wan

Ratajczak

2007

Developmental Dynamics

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Data from our and other laboratories provide evidence that bone marrow (BM) contains a population of stem cells that expresses early developmental markers such as (1) stage-specific embryonic antigen (SSEA) and (2) transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells, and primordial germ cells (PGC). The presence of these stem cells in adult BM supports the concept that this organ contains some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. We hypothesize that these cells could be direct descendants of the germ lineage that, to pass genes on to the next generations, has to create soma and, thus, becomes a "mother lineage" for all somatic cell lineages present in the adult body. Germ potential is established after conception in totipotent zygotes and retained in blastomeres of morula, cells from the inner cell mass of blastocyst, epiblast, and population of PGC. We will present a concept that SSEA ؉ Oct-4 ؉ Nanog ؉ cells identified in BM could be descendants of epiblast cells as well as some rare migrating astray PGC. Developmental Dynamics 236:3309 -3320, 2007.

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Section: Bm-derived Stem Cells and Tissue/organ Regeneration: Evidencmentioning

confidence: 99%

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Kucia

Wan

Ratajczak

2007

Developmental Dynamics

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“…In addition, extracellular vesicles including exosomes and microparticles (MPs) are emerging as novel vectors for cell–cell communication [12,13]. MPs are small plasma membrane-derived vesicles with a diameter of 100–1000 nm which carry a variety of proteins, lipids, mRNA and miRNA arising from the cell of origin [13,14]. MPs have been implicated in a host of physiological and pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Podocyte‐derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36

Munkonda

Akbari

Landry

et al. 2018

J of Extracellular Vesicle

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Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100–1000 nm vesicles shed from injured cells that are implicated in intercellular signalling. Our lab recently observed the formation of MPs from podocytes and their release into urine of animal models of type 1 and 2 diabetes and in humans with type 1 diabetes. The purpose of the present study was to examine the role of podocyte MPs in tubular epithelial cell fibrotic responses. MPs were isolated from the media of differentiated, untreated human podocytes (hPODs) and administered to cultured human proximal tubule epithelial cells (PTECs). Treatment with podocyte MPs increased p38 and Smad3 phosphorylation and expression of the extracellular matrix (ECM) proteins fibronectin and collagen type IV. MP-induced responses were attenuated by co-treatment with the p38 inhibitor SB202190. A transforming growth factor beta (TGF-β) receptor inhibitor (LY2109761) blocked MP-induced Smad3 phosphorylation and ECM protein expression but not p38 phosphorylation suggesting that these responses occurred downstream of p38. Finally, blockade of the class B scavenger receptor CD36 completely abrogated MP-mediated p38 phosphorylation, downstream Smad3 activation and fibronectin/collagen type IV induction. Taken together our results suggest that podocyte MPs interact with proximal tubule cells and induce pro-fibrotic responses. Such interactions may contribute to the development of tubular fibrosis in glomerular disease.

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“…During the process the cells also release phosphatidylserine (PS)-positive membrane fractions called microparticles (MPs). Activated platelets and MPs actively participate in the promulgation of atherosclerosis and related diseases, pathologies of the central nervous system and neoplasia [6].…”

Section: Introductionmentioning

confidence: 99%

Sesamol induces apoptosis in human platelets via reactive oxygen species-mediated mitochondrial damage

Thushara¹,

Hemshekhar²,

Sunitha³

et al. 2013

Biochimie

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Membrane Microparticles: Two Sides of the Coin

Cited by 591 publications

References 46 publications

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Podocyte‐derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36

Sesamol induces apoptosis in human platelets via reactive oxygen species-mediated mitochondrial damage

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