Membrane surface with antibacterial property by grafting polycation

Yang, Yunlei; Hu, Hanqiong; Li, Yang; Wan, Ling‐Shu; Xu, Zhi‐Kang

doi:10.1016/j.memsci.2011.04.012

Cited by 90 publications

(53 citation statements)

References 49 publications

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“…The data indicates that the biocidal activity of the organic monolayers containing quaternary pyridinium groups require a minimum charge density on the substrate for instant cell death. This result also agrees with the finding that there is a charge-density threshold concentration for optimum bactericidal efficiency [9,24].…”

Section: Threshold Concentration Effectsupporting

confidence: 92%

“…Polymeric antibacterial agents represent a novel direction in modifying the surfaces allowing limited biofilm formation. This method prevents the growth of bacteria and the transmission of infectious organisms [5][6][7][8][9][10][11]. Incorporation of biocidal polymers on these types of surfaces enhances antibacterial properties in leaching or non-leaching systems [7,12].…”

Section: Introductionmentioning

confidence: 99%

“…Although, there are many reported studies in the literature, the antibacterial mechanisms for the surface coated polymers are still waiting to be answered [9,[19][20][21][22]. One of the proposed mechanisms suggests that the penetration of cationic polymers into the negatively charged bacterial cell biomembrane causes necrosis [23].…”

Section: Introductionmentioning

confidence: 99%

“…Another hypothesis suggests that the mechanism involves an ion exchange between the http://dx.doi.org/10.1016/j.colsurfb.2015.01.020 0927-7765/© 2015 Elsevier B.V. All rights reserved. positive charges of polycations and the structurally critical mobile cations (Ca 2+ and Mg 2+ ) within the cell biomembranes [9,24]. In this case, charge density threshold plays an important role along with the loss of these structural cations.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of alkyl chain length on the surface activity of antibacterial polymers derived from ROMP

Altay

Yapaöz

Keskin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Threshold Concentration Effectsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of alkyl chain length on the surface activity of antibacterial polymers derived from ROMP

Altay

Yapaöz

Keskin

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…It can be reacted with alkyl halide to produce a polycation chain, and thus can exhibit effective antimicrobial activity [19][20][21][22]. The functional monomer, 4,4 -bipyridine, has attracted considerable interest because of the wide range of applications in electrochromic devices, agriculture, and medicine [23].…”

Section: Introductionmentioning

confidence: 99%

Polycation‐Grafted Poly(vinylidene fluoride) Membrane with Biofouling Resistance

2015

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Covalent immobilization of polycations onto a membrane surface has been shown to significantly improve the resistance to biofouling. The poly(vinylidene fluoride)-graft-poly(N,N-dimethylamino-2-ethylmethacrylate) (PVDF-g-PDMAEMA) copolymer was synthesized via radical grafting copolymerization and fabricated into a flat membrane. The polycation membrane surface was constructed by quaternization of PDMAEMA side chains with 1,5-dibromopentane and diquaternization of 4,4 -bipyridine. As revealed by membrane surface morphology, pore size, and porosity measurement, the polycations are distributed on the membrane surface and internal pore channel surface. Water contact angles confirm that the incorporation of polycations remarkably promotes the surface hydrophilicity of a membrane. The polycation membrane surface provides an excellent bactericidal efficiency against Escherichia coli.

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Synergistic D‐Amino Acids Based Antimicrobial Cocktails Formulated via High‐Throughput Screening and Machine Learning

Yang,

Ran,

Liu

et al. 2023

Advanced Science

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Antimicrobial resistance (AMR) from pathogenic bacterial biofilms has become a global health issue while developing novel antimicrobials is inefficient and costly. Combining existing multiple drugs with enhanced efficacy and/or reduced toxicity may be a promising approach to treat AMR. D‐amino acids mixtures coupled with antibiotics can provide new therapies for drug‐resistance infection with reduced toxicity by lower drug dosage requirements. However, iterative trial‐and‐error experiments are not tenable to prioritize credible drug formulations, owing to the extremely large number of possible combinations. Herein, a new avenue is provide to accelerate the exploration of desirable antimicrobial formulations via high‐throughput screening and machine learning optimization. Such an intelligent method can navigate the large search space and rapidly identify the D‐amino acid mixtures with the highest anti‐biofilm efficiency and also the synergisms between D‐amino acid mixtures and antibiotics. The optimized drug cocktails exhibit high antimicrobial efficacy while remaining non‐toxic, which is demonstrated not only from in vitro assessments but also the first in vivo study using a lung infection mouse model.

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Membrane surface with antibacterial property by grafting polycation

Cited by 90 publications

References 49 publications

Influence of alkyl chain length on the surface activity of antibacterial polymers derived from ROMP

Influence of alkyl chain length on the surface activity of antibacterial polymers derived from ROMP

Polycation‐Grafted Poly(vinylidene fluoride) Membrane with Biofouling Resistance

Synergistic D‐Amino Acids Based Antimicrobial Cocktails Formulated via High‐Throughput Screening and Machine Learning

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