2018
DOI: 10.3390/membranes8040094
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Membrane Technologies for Lactic Acid Separation from Fermentation Broths Derived from Renewable Resources

Abstract: Lactic acid (LA) was produced on a pilot scale using a defined medium with glucose, acid whey, sugar bread and crust bread. The fermentation broths were then subjected to micro- and nanofiltration. Microfiltration efficiently separated the microbial cells. The highest average permeate flow flux was achieved for the defined medium (263.3 L/m2/h) and the lowest for the crust bread-based medium (103.8 L/m2/h). No LA losses were observed during microfiltration of the acid whey, whilst the highest retention of LA w… Show more

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Cited by 34 publications
(19 citation statements)
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“…Table A1, Appendix A summaries literature review related to the cross-flow MF of bacterial suspensions by using ceramic membranes. It indicates that microfiltration process is becoming increasingly attractive in the biotechnology industry in order to obtain a clarified filtrate from various bacterial products such as skim milk [1][2][3][4][5][6], skimmed colostrum [7], gum arabic suspension [8], cell suspension [9][10][11][12], fermentation soy sauce [13,14], and fermentation broths [15][16][17][18][19][20][21][22][23][24][25]. It has to be pointed out that with regard to complex media such as fermentation broths, microfiltration is proposed as a pre-treatment stage for the final separation by nanofiltration (NF) or reverse osmosis (RO) processes with spiral-wound modules [26].…”
Section: Introductionmentioning
confidence: 99%
“…Table A1, Appendix A summaries literature review related to the cross-flow MF of bacterial suspensions by using ceramic membranes. It indicates that microfiltration process is becoming increasingly attractive in the biotechnology industry in order to obtain a clarified filtrate from various bacterial products such as skim milk [1][2][3][4][5][6], skimmed colostrum [7], gum arabic suspension [8], cell suspension [9][10][11][12], fermentation soy sauce [13,14], and fermentation broths [15][16][17][18][19][20][21][22][23][24][25]. It has to be pointed out that with regard to complex media such as fermentation broths, microfiltration is proposed as a pre-treatment stage for the final separation by nanofiltration (NF) or reverse osmosis (RO) processes with spiral-wound modules [26].…”
Section: Introductionmentioning
confidence: 99%
“…This result is different from that obtained for PP membranes, where, after rinsing with NaOH solution, additional water filtration ensured the recovery of initial membranes permeability (Figure 9). In turn, the efficiency of the M4 module slightly increased after backwashing (25 min total, Figure 12, operations 10-14) and only membrane rinsing with 3% H 3 PO 4 solution for 50 min allowed recovery of the initial module performance (Figure 12, operation [15][16][17][18][19][20].…”
Section: Filtration Of Fermentation Broths With Citrobacer Freundii Bacteriamentioning
confidence: 99%
“…Microfiltration (MF) is one of the oldest membrane technologies [ 1 ], which is characterized by operating pressure lower than 0.35 MPa and high permeate fluxes, mainly between 10 −4 and 10 −2 m/s [ 2 ]. Over the last two decades, many attempts have been made by researchers to comprehensively investigate the use of MF in the clarification of fermentation broths [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] and yeast suspensions [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. It is due to the fact that separation of biological materials using conventional centrifugal methods is difficult and expensive [ 33 ].…”
Section: Introductionmentioning
confidence: 99%
“…Microfiltration membrane Cell-recycle batch 0.98 8.7 [123] Microfiltration membrane Pulsed fed-batch 0.95 3.5 [124] Ultrafiltration membrane Repeated batch 0.80 18.0 [125] Ultrafiltration membrane Continuous 0.95 - [127] Micro/nanofiltration membrane Continuous 0.96 12.4 [35] Micro/nanofiltration membrane Batch 0.87 2.1 [128] Nanofiltration membrane Batch -0.6 [111] Nanofiltration membrane Batch -6.1 [112] Electrodialysis Batch -1.8 [113] Electrodialysis Batch 0.77 5.0 [129] Microfiltration membrane and electrodialysis Batch 0.65 3.0 purification of lactic acid faces a new challenge. Whether metal ions, lactic acid, and other carboxylic acids have an adverse effect on separation remains to be solved in this field.…”
Section: Referencementioning
confidence: 99%