Membrane trafficking in breast cancer progression: protein kinase D comes into play

Abstract

Protein kinase D (PKD) is a serine/threonine kinase family that controls important cellular functions, most notably playing a key role in the secretory pathway at the trans-Golgi network. Aberrant expression of PKD isoforms has been found mainly in breast cancer, where it promotes various cellular processes such as growth, invasion, survival and stem cell maintenance. In this review, we discuss the isoform-specific functions of PKD in breast cancer progression, with a particular focus on how the PKD controlled cellular processes might be linked to deregulated membrane trafficking and secretion. We further highlight the challenges of a therapeutic approach targeting PKD to prevent breast cancer progression.

The Golgi Apparatus: A Key Player in Innate Immunity

“…They play a critical role in the export of TGN and maintaining the balance of lipids in Golgi. Abnormal activity of these kinases could be linked to cancer progression by potentially altering membrane trafficking [36][37][38]. Once activated, PKD phosphorylates NLRP3, leading to its release from MAMs and full maturation within the cytosol [35,39].…”