Membrane transport status does not predict peritonitis risk in patients on peritoneal dialysis

So, Sarah; Aw, Laraine; Sud, Kamal; Lee, Vincent

doi:10.1111/nep.13063

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Only a few studies have analyzed the association between PET and subsequent peritonitis. Sarah So et al [ 28 ] analyzed 397 PD patients and concluded that baseline PET could not predict the 10-year peritonitis rate. The D/P ratio did increase in some, but not all patients, after long-term PD treatment; therefore, the rate of peritoneal dysfunction varies widely among individuals.…”

Section: Discussionmentioning

confidence: 99%

Baseline Peritoneal Membrane Transport Characteristics Are Associated with Peritonitis Risk in Incident Peritoneal Dialysis Patients

Chou

Chen

et al. 2022

Membranes

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The peritoneal equilibration test (PET) is a semi-quantitative measurement that characterizes the rate of transfer of solutes and the water transfer rate across the peritoneum in patients treated with peritoneal dialysis (PD). The results of the PET are used to maximize daily peritoneal ultrafiltration and solute clearances. Previous studies have shown that high transport status is associated with ultrafiltration failure, malnutrition, and reduced survival; however, the way in which peritoneum transport characteristics affect peritonitis risk is unknown. In the current cohort study, we recruited 898 incident-PD patients and used intention-to-treat analysis to test if baseline PET affected the subsequent 3-year peritonitis rate. Among all recruited PD patients, 308 (34.2%) developed peritonitis within three years. Multivariate Cox regression analysis showed that the high-transport group has the greatest peritonitis risk (HR 1.98, 95% CI: 1.08–3.62) even after an adjustment for demographics, comorbid diseases, and biochemical measurements. We concluded that a baseline high peritoneal membrane transport rate is an independent risk factor for peritonitis in incident PD patients.

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Section: Discussionmentioning

confidence: 99%

Baseline Peritoneal Membrane Transport Characteristics Are Associated with Peritonitis Risk in Incident Peritoneal Dialysis Patients

Chou

Chen

et al. 2022

Membranes

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“…Higher peritoneal transport is often associated with less ultrafiltration and high albumin loss. Studies have shown that the peritoneal transport status is closely related to the mortality of PD patients [ 14 , 15 ], but few studies have explored the relationship between the peritoneal transport status and the occurrence of peritonitis episodes [ 16 ]. Limited studies have concluded that the type of peritoneal transport does not predict the occurrence of peritonitis, while others have debated over the accuracy of this conclusion [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Peritoneal transport status and first episode of peritonitis: a large cohort study

Zhang

2021

Renal Failure

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Background: Peritonitis is one of the most serious complications of peritoneal dialysis (PD). This study aimed to explore the relationship between peritoneal transport status and the first episode of peritonitis, as well as the prognosis of patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Method: A retrospective cohort study was conducted, analyzing data of CAPD patients from 1st January 2009, to 31st December 2017. Baseline data within 3 months after PD catheter placement was recorded. Cox multivariate regression analysis was performed to determine the risk factors for the first episode of peritonitis, technique failure and overall mortality. Results: A total of 591 patients were included in our analysis, with a mean follow-up visit of 49 months (range: 27-75months). There were 174 (29.4%) patients who had experienced at least one episode of peritonitis. Multivariate Cox regression analysis revealed that a higher peritoneal transport status (high and high-average) (HR 1.872, 95%CI 1.349-2.599, p ¼ 0.006) and hypoalbuminemia (HR 0.932,95% CI 0.896, 0.969, p ¼ 0.004) were independent risk factors for the occurrence of the first episode of peritonitis. In addition, factors including gender (male) (HR 1.409, 95%CI 1.103, 1.800, p ¼ 0.010), low serum albumin (HR 0.965, 95%CI 0.938, 0.993, p ¼ 0.015) and the place of residence (rural) (HR 1.324, 95%CI 1.037, 1.691, p ¼ 0.024) were independent predictors of technique failure. Furthermore, low serum albumin levels (HR 0.938, 95%CI 0.895, 0.984, p ¼ 0.008) and age (>65years) (HR 1.059, 95%CI 1.042, 1.076, p < 0.001) were significantly associated with the risk of overall mortality of PD patients. Conclusions: Baseline hypoalbuminemia and a higher peritoneal transport status are risk factors for the first episode of peritonitis. Factors including male gender, hypoalbuminemia, and residing in rural areas are associated with technique failure, while hypoalbuminemia and age (>65years) are predictors of the overall mortality in PD patients. Nevertheless, the peritoneal transport status does not predict technique failure or overall mortality of PD patients.

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Membrane transport status does not predict peritonitis risk in patients on peritoneal dialysis

Abstract: Smoking and hypoalbuminaemia, but not MTS, were associated with shorter time to first peritonitis and composite endpoint of peritonitis, death and technique failure.

Cited by 2 publications

References 35 publications

Baseline Peritoneal Membrane Transport Characteristics Are Associated with Peritonitis Risk in Incident Peritoneal Dialysis Patients

Baseline Peritoneal Membrane Transport Characteristics Are Associated with Peritonitis Risk in Incident Peritoneal Dialysis Patients

Peritoneal transport status and first episode of peritonitis: a large cohort study

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