Membrane transporters in salivary exosomes and microvesicles as biomarkers of systemic or oral disease

Ishikawa, Yasuko; Pieczonka, Tomasz D.; Bragiel, Aneta M.

doi:10.1016/j.job.2014.06.001

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…However, the effects of Sujiaonori on cardiovascular health have not been investigated. Our preliminary study showed that SBM supplementation increased adiponectin level close to the highest end of normal value in humans (6.42 ng/mL) [ 24 ]. The administration of exogenous adiponectin as a drug is proposed as an alternative therapeutic approach in the management of cardiovascular and metabolic disorders associated with adiponectin deficiency.…”

Section: Resultsmentioning

confidence: 99%

Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans

et al. 2017

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The replenishment of adiponectin—an adipocyte-derived hormone with salutary health effects—has recently been proposed as a new approach to treat hypertension, also ameliorate cardiovascular and metabolic risks. We conducted a prospective placebo-controlled, non-randomized and investigator-blinded dietary intervention study to evaluate the health effects of dietary intake of Sujiaonori (Ulva/Enteromorpha prolifera Müller) algal biomaterial (SBM), especially on adiponectin production, blood pressure (BP), and body mass index (BMI) in human subjects. Participants (N = 32) were divided into two equally sized groups (n = 16 for each group): SBM group (subjects supplemented with 3 g SBM powder twice a day during meal) and the control group (subjects who took 3 g of a supplement made of 70% corn starch powder and 30% spinach twice a day) for four weeks. Two health survey questionnaires (dietary and current health questionnaires) were completed anonymously, saliva sampling was done for adiponectin measurement by ELISA, and blood pressure (BP) and anthropometric parameters were measured at baseline and four weeks later. Student paired t-test was performed to compare baseline and post-intervention data on outcome variables between the two study groups. Results showed a 2.24-fold increase in adiponectin level in SBM group (2.81 and 6.26 ng/mL at baseline and at the end of study, respectively) (p < 0.01); whereas no significant change was observed in controls (3.58 and 3.51 ng/mL, respectively) (p > 0.05). In SBM subjects, an improvement of BP profile was noted with a significant decrease in systolic BP (p < 0.01). A positive correlation was found between SBM supplementation and adiponectin level, whereas an inverse correlation was noted between SBM supplementation and blood pressure, and also BMI. These findings suggest that SBM-increased adiponectin level and improved BP in a sample of Japanese young adults, and has the potential to improve blood pressure in humans.

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Section: Resultsmentioning

confidence: 99%

Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans

et al. 2017

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“…In contrast to microvesicles, which are generated by shedding from the plasma membrane, exosomes are derived from multivesicular bodies that are components of the endocytic pathway [89]. Ishikawa and colleagues summarized studies of membrane transporters in salivary exosomes, and of microvesicles as biomarkers of systemic or oral disease [90]. Biomarker discovery is now progressing with regard to analysis of salivary exosomes and microvesicles.…”

Section: Salivary Glandsmentioning

confidence: 99%

Oral Biosciences: The annual review 2014

Ohshima

2015

Journal of Oral Biosciences

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Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

Bano

Vats

Yadav

et al. 2022

Critical Reviews in Oncology/Hematology

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Membrane transporters in salivary exosomes and microvesicles as biomarkers of systemic or oral disease

Cited by 5 publications

References 55 publications

Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans

Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans

Oral Biosciences: The annual review 2014

Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

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