Membrane vesicles from a <i>Dietzia</i> bacterium containing multiple cargoes and their roles in iron delivery

Wang, Meng; Nie, Yong; Wu, Xiao‐Lei

doi:10.1111/1462-2920.15278

Cited by 14 publications

(10 citation statements)

References 55 publications

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“…These domains formed part of the “core” proteome identified in bEVs from all the isolates tested 84 . The identification, and even enrichment, of siderophores within the bEVs of diverse bacterial species, with both pathogenic and commensal functions, highlights the importance of bEVs as an iron sequestering tool 88–90 …”

Section: Biogenesis Of P Aeruginosa and S Aureus Bev Takes Place Via ...mentioning

confidence: 95%

“…84 The identification, and even enrichment, of siderophores within the bEVs of diverse bacterial species, with both pathogenic and commensal functions, highlights the importance of bEVs as an iron sequestering tool. [88][89][90] The proximity of biofilm inhabitants drives exchange of antimicrobial resistance (AMR) genes and molecules. Multiple groups showed the inclusion of β lactamases, conferring penicillin resistance, within bEV.…”

Section: Proteins Associated With Bevs Protect Biofilm Communities An...mentioning

confidence: 99%

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The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges

Brown

Clayton²,

Stephens

2021

Wound Repair Regeneration

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Chronic wounds are a significant global problem with an increasing economic and patient welfare impact. How wounds move from an acute to chronic, non-healing, state is not well understood although it is likely that it is driven by a poorly regulated local inflammatory state. Opportunistic pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa are well known to stimulate a pro-inflammatory response and so their presence may further drive chronicity. Studies have demonstrated that host cell extracellular vesicles (hEVs), in particular exosomes, have multiple roles in both increasing and decreasing chronicity within wounds; however, the role of bacterial extracellular vesicles (bEVs) is still poorly understood. The aim of this review is to evaluate bEV biogenesis and function within chronic wound relevant bacterial species to determine what, if any, role bEVs may have in driving wound chronicity. We determine that bEVs drive chronicity by both increasing persistence of key pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa and stimulating a pro-inflammatory response by the host. Data also suggest that both bEVs and hEVs show therapeutic promise, providing vaccine candidates, decoy targets for bacterial toxins or modulating the bacterial species within chronic wound biofilms. Caution should, however, be used when interpreting findings to date as the bEV field is still in its infancy and as such lacks consistency in bEV isolation and characterization. It is of primary importance that this is addressed, allowing meaningful conclusions to be drawn and increasing reproducibility within the field.

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Section: Biogenesis Of P Aeruginosa and S Aureus Bev Takes Place Via ...mentioning

confidence: 95%

Section: Proteins Associated With Bevs Protect Biofilm Communities An...mentioning

confidence: 99%

The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges

Brown

Clayton²,

Stephens

2021

Wound Repair Regeneration

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“…Additionally, bacteria-derived EVs ( Diaetzia sp. ) were found to allow homologous bacterial species to share iron ( 106 ).…”

Section: Gut Microbiota: Modulation Of Iron Homeostasismentioning

confidence: 99%

Host and microbiota derived extracellular vesicles: Crucial players in iron homeostasis

Daou¹,

Falabrègue²,

Pourzand³

et al. 2022

Front. Med.

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Iron is a double-edged sword. It is vital for all that’s living, yet its deficiency or overload can be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels. Extracellular vesicles (EVs), now known as major players in cellular communication, potentially play an important role in regulating iron metabolism. The gut microbiota was also recently reported to impact the iron metabolism process and indirectly participate in regulating iron homeostasis, yet there is no proof of whether or not microbiota-derived EVs interfere in this relationship. In this review, we discuss the implication of EVs on iron metabolism and homeostasis. We elaborate on the blooming role of gut microbiota in iron homeostasis while focusing on the possible EVs contribution. We conclude that EVs are extensively involved in the complex iron metabolism process; they carry ferritin and express transferrin receptors. Bone marrow-derived EVs even induce hepcidin expression in β-thalassemia. The gut microbiota, in turn, affects iron homeostasis on the level of iron absorption and possibly macrophage iron recycling, with still no proof of the interference of EVs. This review is the first step toward understanding the multiplex iron metabolism process. Targeting extracellular vesicles and gut microbiota-derived extracellular vesicles will be a huge challenge to treat many diseases related to iron metabolism alteration.

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“…between two species of Clostridium [4]); (f) vesicles (e.g. interspecies iron delivery [74]) or nanotubes (e.g. interspecies amino acid transfer to compensate for amino acid auxotrophies [75]).…”

Section: Direct Interspecies Electron Transfer In Artificial Co-culturesmentioning

confidence: 99%

Microbes trading electricity in consortia of environmental and biotechnological significance

Rotaru

Musat

2021

Current Opinion in Biotechnology

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Favorable interspecies associations prevail in natural microbial assemblages. Some of these favorable associations are cometabolic dependent partnerships in which extracellular electrons are exchanged between species. For such electron exchange to occur, the cells must exhibit electroactive interfaces and get involved in direct cell-to-cell contact (Direct Interspecies Electron Transfer/DIET) or use available conductive mineral grains from their environment (Conductiveparticle-mediated Interspecies Electron Transfer/CIET). This review will highlight recent discoveries and knowledge gaps regarding DIET and CIET interspecies associations in artificial co-cultures and consortia from natural and man-made environments and emphasize approaches to validate DIET and CIET. Additionally, we acknowledge the initiation of a movement towards applying electric syntrophies in biotechnology, bioremediation and geoengineering for natural attenuation of toxic compounds. Next, we have highlighted the urgent research needs that must be met to develop such technologies.

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Membrane vesicles from a Dietzia bacterium containing multiple cargoes and their roles in iron delivery

Cited by 14 publications

References 55 publications

The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges

The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges

Host and microbiota derived extracellular vesicles: Crucial players in iron homeostasis

Microbes trading electricity in consortia of environmental and biotechnological significance

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