Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells

Caballano-Infantes, Estefanía; Ho-Plágaro, Ailec; Lopez‐Gómez, Carlos; Martín‐Reyes, Flores; Rodríguez‐Pacheco, Francisca; Taminiau, Bernard; Daube, Georges; Garrido‐Sánchez, Lourdes; Alcaín‐Martínez, Guillermo; Bellido, Raúl J. Andrade; García‐Cortés, Miren; Lucena, M. Isabel; Garcı́a-Fuentes, Eduardo; Rodríguez‐Díaz, Cristina

doi:10.3390/antiox12040818

Cited by 4 publications

(2 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, exposure of intestinal cells to C. difficile EVs induces a dose-dependent proinflammatory and cytotoxic response [ 125 ]. Caballano et al found that despite the absence of TcdA and TcdB in C. difficile EVs, their epithelial toxicity involves the expression of apoptosis-related genes (CASP3), an effect that was not distinguished in non-toxigenic strains of C. difficile [ 128 ].…”

Section: Extracellular Vesicles In Other Medically Important Bacteriamentioning

confidence: 99%

See 1 more Smart Citation

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

Peregrino,

Castañeda-Casimiro,

Vázquez-Flores

et al. 2024

IJMS

View full text Add to dashboard Cite

Pathogenic bacteria have several mechanisms to evade the host’s immune response and achieve an efficient infection. Bacterial extracellular vesicles (EVs) are a relevant cellular communication mechanism, since they can interact with other bacterial cells and with host cells. In this review, we focus on the EVs produced by some World Health Organization (WHO) priority Gram-negative and Gram-positive pathogenic bacteria; by spore-producing bacteria; by Mycobacterium tuberculosis (a bacteria with a complex cell wall); and by Treponema pallidum (a bacteria without lipopolysaccharide). We describe the classification and the general properties of bacterial EVs, their role during bacterial infections and their effects on the host immune response. Bacterial EVs contain pathogen-associated molecular patterns that activate innate immune receptors, which leads to cytokine production and inflammation, but they also contain antigens that induce the activation of B and T cell responses. Understanding the many effects of bacterial EVs on the host’s immune response can yield new insights on the pathogenesis of clinically important infections, but it can also lead to the development of EV-based diagnostic and therapeutic strategies. In addition, since EVs are efficient activators of both the innate and the adaptive immune responses, they constitute a promising platform for vaccine development.

show abstract

Section: Extracellular Vesicles In Other Medically Important Bacteriamentioning

confidence: 99%

“…B. cereus EVs induce TNFα production in monocytes and cause enterocyte lysis [ 127 ]. Exposure of intestinal and hepatic cells to C. difficile EVs induces the production of IL-1β, IL-6, IL-8, and MCP-1 [ 125 , 128 ].…”

Section: Immunological Effects Of Bacterial Extracellular Vesiclesmentioning

confidence: 99%

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

Peregrino,

Castañeda-Casimiro,

Vázquez-Flores

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

The emerging role of bacterial extracellular vesicles in human cancers

Liang,

Korani,

Yeung

et al. 2024

J of Extracellular Vesicle

View full text Add to dashboard Cite

Bacterial extracellular vesicles (BEVs) have emerged as pivotal mediators between bacteria and host. In addition to being crucial players in host homeostasis, they have recently been implicated in disease pathologies such as cancer. Hence, the study of BEVs represents an intriguing and rapidly evolving field with substantial translational potential. In this review, we briefly introduce the fundamentals of BEV characteristics, cargo and biogenesis. We emphatically summarize the current relationship between BEVs across various cancer types, illustrating their role in tumorigenesis, treatment responses and patient survival. We further discuss the inherent advantages of BEVs, such as stability, abundance and specific cargo profiles, that make them attractive candidates for non‐invasive diagnostic and prognostic approaches. The review also explores the potential of BEVs as a strategy for cancer therapy, considering their ability to deliver therapeutic agents, modulate the tumour microenvironment (TME) and elicit immunomodulatory responses. Understanding the clinical significance of BEVs may lead to the development of better‐targeted and personalized treatment strategies. This comprehensive review evaluates the current progress surrounding BEVs and poses questions to encourage further research in this emerging field to harness the benefits of BEVs for their full potential in clinical applications against cancer.

show abstract

Clostridioides difficile PCR ribotypes 001 and 084 can trigger autophagy process in human intestinal Caco-2 cells

Azimirad,

Noori,

Amirkamali

et al. 2023

Microbial Pathogenesis

View full text Add to dashboard Cite

Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells

Cited by 4 publications

References 78 publications

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

The emerging role of bacterial extracellular vesicles in human cancers

Clostridioides difficile PCR ribotypes 001 and 084 can trigger autophagy process in human intestinal Caco-2 cells

Contact Info

Product

Resources

About