2002
DOI: 10.1128/aem.68.11.5223-5230.2002
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Membranes of Class IIa Bacteriocin-Resistant Listeria monocytogenes Cells Contain Increased Levels of Desaturated and Short-Acyl-Chain Phosphatidylglycerols

Abstract: A major concern in the use of class IIa bacteriocins as food preservatives is the well-documented resistance development in target Listeria strains. We studied the relationship between leucocin A, a class IIa bacteriocin, and the composition of the major phospholipid, phosphatidylglycerol (PG), in membranes of both sensitive and resistant L. monocytogenes strains. Two wild-type strains, L. monocytogenes B73 and 412, two spontaneous mutants of L. monocytogenes B73 with intermediate resistance to leucocin A (؎2.… Show more

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Cited by 102 publications
(82 citation statements)
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“…The exact resistance mechanism in these cases is unknown, but changes in the cell envelope (e.g. membrane fluidity or cell surface charge) have been found to be associated with these resistant cells (Vadyvaloo et al, 2002(Vadyvaloo et al, , 2004b. Probably, such changes can mask or interfere with the bacteriocin-receptor interaction, thereby rendering cells resistant to bacteriocins.…”
Section: Transport Systems Confer Immunitymentioning
confidence: 99%
“…The exact resistance mechanism in these cases is unknown, but changes in the cell envelope (e.g. membrane fluidity or cell surface charge) have been found to be associated with these resistant cells (Vadyvaloo et al, 2002(Vadyvaloo et al, , 2004b. Probably, such changes can mask or interfere with the bacteriocin-receptor interaction, thereby rendering cells resistant to bacteriocins.…”
Section: Transport Systems Confer Immunitymentioning
confidence: 99%
“…This has in turn spurred interest into understanding resistance phenomena displayed by the pathogen. In strains of the food-borne pathogen Listeria monocytogenes, there is crossresistance between different class IIa bacteriocins, indicating common or similar resistance mechanisms (Vadyvaloo et al, 2002). A prevalent mechanism involving the loss of the enzyme IIAB subunit of a mannose-specific phosphotransferase system (EIIAB Man PTS, encoded by mptA) was recently described (Dalet et al, 2001;Gravesen et al, 2002).…”
Section: Reports Of Resistance Development By Listerial Strains Againmentioning
confidence: 99%
“…The cell wall of L. monocytogenes is composed by a thick peptidoglycan layer containing two types of anionic polymers: teichoic acids (TA), which are covalently linked to the peptidoglycan, and lipoteichoic acids (LTAs), which are poly phosphoglycerols substituted with a Dalanyl ester or a glycosyl residue and anchored in the membrane by their glycolipid moiety [44]. Some authors suggest that bacteriocininduced lysis could be due to the release of autolytic enzymes that are usually electrostatically bound to anionic polymers (TA and LTAs) of the cell wall, which are displaced by cationic bacteriocins from their binding sites [45][46][47].…”
Section: Resultsmentioning
confidence: 99%